Species

KNApSAcK Entry

Organism name Swertia perennis
Genus Swertia
Family Gentianaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Swertia perennis
Linked NCBI taxonomy ID 39379
Linked level species

Family

Family in NCBI taxonomy Gentianaceae
ID 21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006169 External link 512 Isoorientin 6''-O-alpha-L-arabinoside
No. 1 No. 15
C00002975 External link 512 Swertianolin
CHEMBL468396
CHEMBL1901330
5 / 2 / 1 No. 2 No. 15
C00002966 External link 512 Swertiaperennin
/ Methylswertianin
/ 1,8-Dihydroxy-3,7-dimethoxyxanthone
No. 3 No. 15
C00002952 External link 512 Gentiacaulein
/ 1,7-Dihydroxy-3,8-dimethoxyxantone
CHEMBL467590
12 / 26 / 53 No. 3 No. 15
C00037010 External link 512 Decussatin
/ 1-Hydroxy-3,7,8-trimethoxyxanthone
CHEMBL26323
1 / 1 / 1 No. 3 No. 15
C00002974 External link 512 Swertianin
/ Gentiakochianin
CHEMBL187044
1 / 1 / 1 No. 3 No. 15
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00002970 External link 512 Norswertianin
/ 1,3,7,8-Tetrahydroxanthone
CHEMBL187043
1 / 1 / 1 No. 71 No. 15

Human Protein / Gene in interactions

40 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002970 C00002974 C00002975 C00037010 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 C00002952 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 C00002952 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001059 C00002952 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001059 C00002952 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 C00002975 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002975 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002952 11 / 10
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001059 1 / 0
P06746 DNA polymerase beta Enzyme C00001059 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
P39748 Flap endonuclease 1 Enzyme C00001059 0 / 0
O75496 Geminin Unclassified protein C00002975 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002952 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00001059 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002952 2 / 2
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00002975 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002952 7 / 37
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001059 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001059 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002952 4 / 3
Q99700 Ataxin-2 Unclassified protein C00002952 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001059 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001059 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002952 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 1 / 0
O00255 Menin Unclassified protein C00001059 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001059 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002952 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (48)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (70)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)