Species

KNApSAcK Entry

Organism name Rosa centifolia
Genus Rosa
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rosa x centifolia
Linked NCBI taxonomy ID 396733
Linked level species

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (18)

Species Activity
Rosa centifolia L. Antidiarrheic
Rosa centifolia L. Antiinflammatory
Rosa centifolia L. Aperient
Rosa centifolia L. Aperitif
Rosa centifolia L. Aphrodisiac
Rosa centifolia L. Ascaricide
Rosa centifolia L. Astringent
Rosa centifolia L. Cardiotonic
Rosa centifolia L. Carminative
Rosa centifolia L. Depurative
Rosa centifolia L. Emollient
Rosa centifolia L. Expectorant
Rosa centifolia L. Laxative
Rosa centifolia L. Nervine
Rosa centifolia L. Stomachic
Rosa centifolia L. Tonic
Rosa centifolia L. Vermifuge
Rosa centifolia L. Vulnerary

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001075 External link 512 Nevadensin
CHEMBL312073
C023982
1 / 0 / 0 No. 3 No. 15
C00004692 External link 512 Chrysosplenol D
/ Quercetagetin 3,6,7-Trimethyl ether
/ 5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone
/ 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL491366
1 / 0 / 0 No. 3 No. 15
C00004600 External link 512 3,5,7-Trihydroxy-6,4'-dimethoxyflavone
/ 6,4'-Dimethoxy-3,5,7-trihydroxyflavone
CHEMBL311155
No. 3 No. 15
C00004671 External link 512 Araneosol
/ 5,7-Dihydroxy-3,4',6,8-tetramethoxyflavone
/ 5,7-Dihydroxy-3,6,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
No. 8 No. 15
C00004673 External link 512 5-Hydroxyauranetin
/ 5-Hydroxy-3,6,7,8,4'-pentamethoxyflavone
/ 5-Hydroxy-3,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-Benzopyran-4-one
CHEMBL504047
No. 8 No. 15
C00003883 External link 512 Gardenin B
/ Demethyltangeretin
/ 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL226512
7 / 10 / 4 No. 8 No. 15
C00004794 External link 512 5,7,4'-Trihydroxy-3,6,8,3'-tetramethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,8-trimethoxy-4H-1-benzopyran-4-one
CHEMBL77156
15 / 7 / 2 No. 8 No. 15

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00001075 C00003883 0 / 0
P04350 Tubulin beta-4A chain Structural C00004794 2 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003883 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003883 2 / 0
O75496 Geminin Unclassified protein C00003883 0 / 0
P15121 Aldose reductase Enzyme C00004692 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003883 7 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00003883 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004794 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004794 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004794 1 / 0
Q99700 Ataxin-2 Unclassified protein C00003883 1 / 1
Q3ZCM7 Tubulin beta-8 chain Structural C00004794 0 / 0
P07437 Tubulin beta chain Structural C00004794 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004794 1 / 1
P68371 Tubulin beta-4B chain Structural C00004794 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004794 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00004794 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004794 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004794 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004794 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004794 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004794 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG name UniProt
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)