Species

KNApSAcK Entry

Organism name Gardenia lucida
Genus Gardenia
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Gardenia
Linked NCBI taxonomy ID 43486
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001075 External link 512 Nevadensin
CHEMBL312073
C023982
1 / 0 / 0 No. 3 No. 15
C00003850 External link 512 8-Methoxyapigenin
/ 4'-Hydroxywogonin
/ Isoscutellarein 8-methyl ether
/ 5,7,4'-Trihydroxy-8-methoxyflavone
CHEMBL245712
C093385
No. 3 No. 15
C00003876 External link 512 Desmethoxysudachitin
/ 5,7,4'-Trihydroxy-6,8-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethoxy-4H-1-benzopyran-4-one
CHEMBL476120
C078367
No. 3 No. 15
C00003959 External link 512 5,7,3'-Trihydroxy-8,4',5'-trimethoxyflavone
No. 3 No. 15
C00003907 External link 512 Onopordin
/ 8-Methoxyluteolin
/ 5,7,3',4'-Tetrahydroxy-8-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-methoxy-4H-1-benzopyran-4-one
CHEMBL476730
No. 3 No. 15
C00003910 External link 512 3',4'-Dimethoxywogonin
/ Hypolaetin 8,3',4'-trimethyl ether
/ 5,7-Dihydroxy-8,3',4'-trimethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-8-methoxy-4H-1-benzopyran-4-one
No. 3 No. 15
C00003958 External link 512 5,7,3',5'-Tetrahydroxy-8,4'-dimethoxyflavone
No. 3 No. 15
C00003957 External link 512 3',4',5'-Trihydroxywogonin
No. 3 No. 15
C00003883 External link 512 Gardenin B
/ Demethyltangeretin
/ 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL226512
7 / 10 / 4 No. 8 No. 15
C00003961 External link 512 3',4',5'-Trimethoxywogonin
/ 5,7-Dihydroxy-8,3',4',5'-tetramethoxyflavone
/ 5,7-Dihydroxy-8-methoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
No. 8 No. 15
C00003970 External link 512 Gardenin E
/ 3',5,5'-Trihydroxy-4',6,7,8-tetramethoxyflavone
/ 2-(3,5-Dihydroxy-4-methoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00003972 External link 512 Gardenin C
/ 3',5-Dihydroxy-4',5',6,7,8-pentamethoxyflavon
/ 5-Hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00003976 External link 512 Gardenin A
/ 5-Hydroxy-3',4',5',6,7,8-hexamethoxyflavone
/ 5-Hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL77705
21 / 18 / 8 No. 8 No. 15

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00001075 C00003883 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003883 C00003976 7 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00003883 C00003976 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00003976 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003883 2 / 0
O75496 Geminin Unclassified protein C00003883 0 / 0
P37840 Alpha-synuclein Unclassified protein C00003976 4 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00003883 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003976 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003976 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003976 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00003976 0 / 0
P68366 Tubulin alpha-4A chain Structural C00003976 0 / 0
Q99700 Ataxin-2 Unclassified protein C00003883 1 / 1
P04350 Tubulin beta-4A chain Structural C00003976 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00003976 0 / 0
P07437 Tubulin beta chain Structural C00003976 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00003976 1 / 1
P68371 Tubulin beta-4B chain Structural C00003976 0 / 0
Q13509 Tubulin beta-3 chain Structural C00003976 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00003976 0 / 0
Q13885 Tubulin beta-2A chain Structural C00003976 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00003976 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00003976 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00003976 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00003976 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#127750 Dementia, lewy body; dlb P37840
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (9)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)