KNApSAcK Metabolite C00003976
Metabolite
KNApSAcK Entry
| id | C00003976 |
|---|---|
| Name | Gardenin A / 5-Hydroxy-3',4',5',6,7,8-hexamethoxyflavone / 5-Hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one |
| CAS RN | 21187-73-5 |
| Standard InChI | InChI=1S/C21H22O9/c1-24-13-7-10(8-14(25-2)17(13)26-3)12-9-11(22)15-16(23)19(27-4)21(29-6)20(28-5)18(15)30-12/h7-9,23H,1-6H3 |
| Standard InChI (Main Layer) | InChI=1S/C21H22O9/c1-24-13-7-10(8-14(25-2)17(13)26-3)12-9-11(22)15-16(23)19(27-4)21(29-6)20(28-5)18(15)30-12/h7-9,23H,1-6H3 |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 8 |
Link
ChEMBL
| By standard InChI | CHEMBL77705 |
|---|---|
| By standard InChI Main Layer | CHEMBL77705 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 2 |
| eudicotyledons | 1 |
| rosids | 1 |
Family
| family name | count |
|---|---|
| Rubiaceae | 2 |
| Tamaricaceae | 1 |
| Rutaceae | 1 |
List (4)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Gardenia gummifera | 1357586 | Rubiaceae | asterids | Viridiplantae |
| Gardenia lucida | 43486 | Rubiaceae | asterids | Viridiplantae |
| Murraya paniculata | 43711 | Rutaceae | rosids | Viridiplantae |
| Tamarix dioica | 63084 | Tamaricaceae | eudicotyledons | Viridiplantae |
Human Protein / Gene in interaction
21 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P37840 | Alpha-synuclein | Unclassified protein | CHEMBL77705 |
CHEMBL2354282
(1)
|
4 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL77705 |
CHEMBL1614458
(1)
|
0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL77705 |
CHEMBL2114810
(1)
|
7 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL77705 |
CHEMBL1738588
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL77705 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL77705 |
CHEMBL1738184
(1)
|
0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| P07437 | Tubulin beta chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
2 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | CHEMBL77705 |
CHEMBL818984
(1)
CHEMBL820476
(1)
|
1 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
KEGG DISEASE (8)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|