| Organism name | Veronicastrum virginicum (L.) Farw. | 
|---|---|
| Genus | Veronicastrum | 
| Family | Plantaginaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Veronicastrum | 
|---|---|
| Linked NCBI taxonomy ID | 74694 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Plantaginaceae | 
|---|---|
| ID | 156152 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| Species | Activity | 
|---|---|
| Veronicastrum virginicum (L.) Farw. | Antiseptic | 
| Veronicastrum virginicum (L.) Farw. | Carminative | 
| Veronicastrum virginicum (L.) Farw. | Cholagogue | 
| Veronicastrum virginicum (L.) Farw. | Choleretic | 
| Veronicastrum virginicum (L.) Farw. | Depurative | 
| Veronicastrum virginicum (L.) Farw. | Diaphoretic | 
| Veronicastrum virginicum (L.) Farw. | Emetic | 
| Veronicastrum virginicum (L.) Farw. | Hepatotonic | 
| Veronicastrum virginicum (L.) Farw. | Laxative | 
| Veronicastrum virginicum (L.) Farw. | Tonic | 
| Veronicastrum virginicum (L.) Farw. | toxic | 
| KNApSAcK ID | name | ChEMBL link | CTD link | 
                        # of proteins in
                         ChEMBL interaction / related OMIM / related KEGG DISEASE  | 
                      
                        # of genes in
                         CTD interaction / related diseases  | 
                      
                        KCF-S
                         cluster  | 
                      
                        phytochemical
                         cluster  | 
                      figure | 
|---|---|---|---|---|---|---|---|---|
| 
                        C00010600
                        
                           | 
                      
                        Ajugol
                         / Leonuride  | 
                      
                        CHEMBL595516
                         | 
                      No. 64 | No. 36 | 
                         
                       | 
                    |||
| 
                        C00003075
                        
                           | 
                      
                        Catalpol
                         | 
                      
                        CHEMBL513223
                         | 
                      
                        C078040
                         | 
                      2 / 1 / 1 | 0 / 2 | No. 64 | No. 36 | 
                         
                       | 
                    
| 
                        C00001165
                        
                           | 
                      
                        Mannitol
                         / D-Mannitol  | 
                      
                        CHEMBL16105
                         CHEMBL689 CHEMBL1682 CHEMBL1735282 CHEMBL1773904  | 
                      
                        D008353
                         | 
                      101 / 49 / 42 | 10 / 42 | No. 630 | 
                         
                       | 
                    
| accession | description | class description | KNApSAcK metabolite in interactions | 
                          # of diseases
                           (OMIM / KEGG)  | 
                      
|---|---|---|---|---|
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001165 C00003075 | 0 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00001165 C00003075 | 1 / 1 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001165 | 0 / 0 | 
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00001165 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001165 | 0 / 3 | 
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001165 | 2 / 2 | 
| P08246 | Neutrophil elastase | S1A | C00001165 | 2 / 1 | 
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001165 | 0 / 0 | 
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001165 | 0 / 0 | 
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001165 | 0 / 0 | 
| P29466 | Caspase-1 | C14 | C00001165 | 0 / 0 | 
| P17252 | Protein kinase C alpha type | Alpha | C00001165 | 0 / 0 | 
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001165 | 0 / 0 | 
| P14780 | Matrix metalloproteinase-9 | M10A | C00001165 | 2 / 2 | 
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001165 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00001165 | 11 / 10 | 
| P00918 | Carbonic anhydrase 2 | Lyase | C00001165 | 1 / 2 | 
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 1 | 
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001165 | 1 / 1 | 
| P25021 | Histamine H2 receptor | Histamine receptor | C00001165 | 0 / 0 | 
| P35367 | Histamine H1 receptor | Histamine receptor | C00001165 | 0 / 0 | 
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001165 | 1 / 0 | 
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001165 | 0 / 0 | 
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 0 | 
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 0 | 
| P08183 | Multidrug resistance protein 1 | drug | C00001165 | 1 / 0 | 
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001165 | 0 / 0 | 
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001165 | 0 / 0 | 
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001165 | 0 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001165 | 0 / 1 | 
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001165 | 1 / 8 | 
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001165 | 2 / 0 | 
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001165 | 0 / 0 | 
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001165 | 0 / 0 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001165 | 0 / 0 | 
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001165 | 0 / 0 | 
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001165 | 0 / 0 | 
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001165 | 0 / 0 | 
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001165 | 1 / 1 | 
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001165 | 0 / 0 | 
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001165 | 1 / 0 | 
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001165 | 0 / 0 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00001165 | 0 / 0 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001165 | 1 / 0 | 
| O75496 | Geminin | Unclassified protein | C00001165 | 0 / 0 | 
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001165 | 0 / 0 | 
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 0 | 
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001165 | 0 / 0 | 
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001165 | 0 / 0 | 
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001165 | 1 / 0 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001165 | 0 / 0 | 
| Q92731 | Estrogen receptor beta | NR3A2 | C00001165 | 0 / 1 | 
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001165 | 0 / 0 | 
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001165 | 0 / 0 | 
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001165 | 0 / 0 | 
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001165 | 1 / 0 | 
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001165 | 0 / 0 | 
| P08311 | Cathepsin G | S1A | C00001165 | 0 / 0 | 
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001165 | 1 / 0 | 
| P03956 | Interstitial collagenase | M10A | C00001165 | 0 / 1 | 
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001165 | 0 / 0 | 
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001165 | 0 / 0 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001165 | 0 / 0 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00001165 | 0 / 1 | 
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001165 | 2 / 0 | 
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001165 | 0 / 0 | 
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001165 | 0 / 0 | 
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001165 | 2 / 0 | 
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001165 | 5 / 9 | 
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001165 | 1 / 0 | 
| P21452 | Substance-K receptor | Neurokinin receptor | C00001165 | 0 / 0 | 
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001165 | 0 / 0 | 
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001165 | 3 / 0 | 
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001165 | 0 / 0 | 
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001165 | 1 / 0 | 
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001165 | 0 / 0 | 
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001165 | 2 / 1 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001165 | 0 / 0 | 
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001165 | 0 / 0 | 
| P10323 | Acrosin | S1A | C00001165 | 0 / 0 | 
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001165 | 1 / 0 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00001165 | 1 / 0 | 
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001165 | 0 / 0 | 
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001165 | 0 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001165 | 0 / 0 | 
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001165 | 0 / 0 | 
| P25103 | Substance-P receptor | Neurokinin receptor | C00001165 | 0 / 0 | 
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001165 | 0 / 0 | 
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001165 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001165 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001165 | 0 / 1 | 
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001165 | 0 / 0 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001165 | 0 / 0 | 
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001165 | 1 / 1 | 
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 0 | 
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001165 | 0 / 0 | 
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001165 | 0 / 0 | 
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001165 | 1 / 1 | 
| P06239 | Tyrosine-protein kinase Lck | Src | C00001165 | 0 / 1 | 
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001165 | 0 / 0 | 
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001165 | 1 / 1 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | 
                          C00001165
                           | 
                      
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | 
                          C00001165
                           | 
                      
| 3479 | IGF1, IGF-I, IGF1A, IGFI | insulin-like growth factor 1 (somatomedin C) | 
                          C00001165
                           | 
                      
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) | 
                          C00001165
                           | 
                      
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) | 
                          C00001165
                           | 
                      
| 4878 | NPPA, ANF, ANP, ATFB6, CDD-ANF, PND | natriuretic peptide A | 
                          C00001165
                           | 
                      
| 27250 | PDCD4, H731 | programmed cell death 4 (neoplastic transformation inhibitor) | 
                          C00001165
                           | 
                      
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) | 
                          C00001165
                           | 
                      
| 7128 | TNFAIP3, A20, OTUD7C, TNFA1P2 | tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) | 
                          C00001165
                           | 
                      
| 7163 | TPD52, D52, N8L, PC-1, PrLZ, hD52 | tumor protein D52 | 
                          C00001165
                           | 
                      
| OMIM | preferred title | UniProt | 
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism | 
                            P20309
                             | 
                        
| #103780 | Alcohol dependence | 
                            P08172
                             P14416 P31645  | 
                        
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 | 
                            Q13148
                             | 
                        
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 | 
                            Q99720
                             | 
                        
| #602025 | Body mass index quantitative trait locus 9; bmiq9 | 
                            P41968
                             | 
                        
| #300615 | Brunner syndrome | 
                            P21397
                             | 
                        
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | 
                            P02545
                             | 
                        
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | 
                            P02545
                             | 
                        
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | 
                            P02545
                             | 
                        
| #162800 | Cyclic neutropenia | 
                            P08246
                             | 
                        
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 | 
                            P51681
                             | 
                        
| #609535 | Drug metabolism, poor, cyp2c19-related | 
                            P33261
                             | 
                        
| #608902 | Drug metabolism, poor, cyp2d6-related | 
                            P10635
                             | 
                        
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | 
                            P02545
                             | 
                        
| #615363 | Estrogen resistance; estrr | 
                            P03372
                             | 
                        
| #613659 | Gastric cancer | 
                            P04626
                             | 
                        
| #137215 | Gastric cancer, hereditary diffuse; hdgc | 
                            P04626
                             | 
                        
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd | 
                            P24557
                             | 
                        
| #137800 | Glioma susceptibility 1; glm1 | 
                            P04626
                             | 
                        
| #610140 | Heart-hand syndrome, slovenian type | 
                            P02545
                             | 
                        
| #609423 | Human immunodeficiency virus type 1, susceptibility to | 
                            P41597
                             P51681  | 
                        
| #176670 | Hutchinson-gilford progeria syndrome; hgps | 
                            P02545
                             | 
                        
| #612244 | Inflammatory bowel disease 13; ibd13 | 
                            P08183
                             | 
                        
| #603932 | Intervertebral disc disease; idd | 
                            P14780
                             | 
                        
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | 
                            P02545
                             | 
                        
| #613688 | Long qt syndrome 2; lqt2 | 
                            Q12809
                             | 
                        
| #211980 | Lung cancer | 
                            P00533
                             P04626  | 
                        
| #608516 | Major depressive disorder; mdd | 
                            P08172
                             | 
                        
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | 
                            P02545
                             | 
                        
| %300852 | Mental retardation, x-linked 88; mrx88 | 
                            P50052
                             | 
                        
| #613073 | Metaphyseal anadysplasia 2; mandp2 | 
                            P14780
                             | 
                        
| #126200 | Multiple sclerosis, susceptibility to; ms | 
                            P08575
                             | 
                        
| #613205 | Muscular dystrophy, congenital, lmna-related | 
                            P02545
                             | 
                        
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | 
                            P02545
                             | 
                        
| #159900 | Myoclonic dystonia | 
                            P14416
                             | 
                        
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 | 
                            P08246
                             | 
                        
| #601665 | Obesity | 
                            P32245
                             | 
                        
| #164230 | Obsessive-compulsive disorder; ocd | 
                            P31645
                             | 
                        
| #604715 | Orthostatic intolerance | 
                            P23975
                             | 
                        
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 | 
                            P00918
                             | 
                        
| #167000 | Ovarian cancer | 
                            P04626
                             | 
                        
| #613135 | Parkinsonism-dystonia, infantile; pkdys | 
                            Q01959
                             | 
                        
| #607276 | Resting heart rate, variation in | 
                            P08588
                             | 
                        
| #275210 | Restrictive dermopathy, lethal | 
                            P02545
                             | 
                        
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive | 
                            P08575
                             | 
                        
| #609620 | Short qt syndrome 1; sqt1 | 
                            Q12809
                             | 
                        
| #190300 | Tremor, hereditary essential, 1; etm1 | 
                            P35462
                             | 
                        
| #610379 | West nile virus, susceptibility to | 
                            P51681
                             | 
                        
| #112100 | Yt blood group antigen | 
                            P22303
                             | 
                        
| KEGG | name | UniProt | 
|---|---|---|
| H00016 | Oral cancer | 
                            P00533
                            (related)
                             P00533 (marker)  | 
                        
| H00017 | Esophageal cancer | 
                            P00533
                            (related)
                             P35354 (related)  | 
                        
| H00018 | Gastric cancer | 
                            P00533
                            (related)
                             P04626 (related)  | 
                        
| H00022 | Bladder cancer | 
                            P00533
                            (related)
                             P04626 (related)  | 
                        
| H00028 | Choriocarcinoma | 
                            P00533
                            (related)
                             P03956 (related) P04626 (related)  | 
                        
| H00030 | Cervical cancer | 
                            P00533
                            (related)
                             P04626 (related)  | 
                        
| H00042 | Glioma | 
                            P00533
                            (related)
                             P00533 (marker)  | 
                        
| H00055 | Laryngeal cancer | 
                            P00533
                            (related)
                             P00533 (marker)  | 
                        
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) | 
                            P00918
                            (related)
                             | 
                        
| H00436 | Osteopetrosis | 
                            P00918
                            (related)
                             | 
                        
| H00264 | Charcot-Marie-Tooth disease (CMT) | 
                            P02545
                            (related)
                             | 
                        
| H00294 | Dilated cardiomyopathy (DCM) | 
                            P02545
                            (related)
                             | 
                        
| H00420 | Familial partial lipodystrophy (FPL) | 
                            P02545
                            (related)
                             | 
                        
| H00563 | Emery-Dreifuss muscular dystrophy | 
                            P02545
                            (related)
                             | 
                        
| H00590 | Congenital muscular dystrophies (CMD/MDC) | 
                            P02545
                            (related)
                             | 
                        
| H00593 | Limb-girdle muscular dystrophy (LGMD) | 
                            P02545
                            (related)
                             | 
                        
| H00601 | Hutchinson-Gilford progeria syndrome | 
                            P02545
                            (related)
                             | 
                        
| H00663 | Restrictive dermopathy | 
                            P02545
                            (related)
                             | 
                        
| H00665 | Mandibuloacral dysplasia | 
                            P02545
                            (related)
                             | 
                        
| H01216 | Left ventricular noncompaction (LVNC) | 
                            P02545
                            (related)
                             | 
                        
| H00026 | Endometrial Cancer | 
                            P03372
                            (marker)
                             P04626 (related) Q92731 (marker)  | 
                        
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | 
                            P04150
                            (related)
                             | 
                        
| H00019 | Pancreatic cancer | 
                            P04626
                            (related)
                             | 
                        
| H00027 | Ovarian cancer | 
                            P04626
                            (related)
                             | 
                        
| H00031 | Breast cancer | 
                            P04626
                            (related)
                             P04626 (marker)  | 
                        
| H00046 | Cholangiocarcinoma | 
                            P04626
                            (related)
                             P35354 (related)  | 
                        
| H00093 | Combined immunodeficiencies (CIDs) | 
                            P06239
                            (related)
                             | 
                        
| H00079 | Asthma | 
                            P07550
                            (related)
                             | 
                        
| H00100 | Neutropenic disorders | 
                            P08246
                            (related)
                             | 
                        
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) | 
                            P08575
                            (related)
                             | 
                        
| H00036 | Osteosarcoma | 
                            P08684
                            (marker)
                             | 
                        
| H01205 | Coumarin resistance | 
                            P11712
                            (related)
                             | 
                        
| H00025 | Penile cancer | 
                            P14780
                            (related)
                             P35354 (related)  | 
                        
| H00479 | Metaphyseal dysplasias | 
                            P14780
                            (related)
                             | 
                        
| H00548 | Brunner syndrome | 
                            P21397
                            (related)
                             | 
                        
| H01031 | Orthostatic intolerance (OI) | 
                            P23975
                            (related)
                             | 
                        
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) | 
                            P24557
                            (related)
                             | 
                        
| H01171 | Poor drug metabolism (PM) | 
                            P33261
                            (related)
                             | 
                        
| H00480 | Non-syndromic X-linked mental retardation | 
                            P50052
                            (related)
                             | 
                        
| H00720 | Long QT syndrome | 
                            Q12809
                            (related)
                             | 
                        
| H00725 | Short QT syndrome | 
                            Q12809
                            (related)
                             | 
                        
| H00058 | Amyotrophic lateral sclerosis (ALS) | 
                            Q13148
                            (related)
                             | 
                        
| MESH or OMIM | name | 
                            KNApSAcK
                             metabolite  | 
                        
|---|---|---|
| D007249 | Inflammation | 
                            C00003075
                             | 
                        
| D019636 | Neurodegenerative Diseases | 
                            C00003075
                             | 
                        
| D058186 | Acute Kidney Injury | 
                            C00001165
                             | 
                        
| D055371 | Acute Lung Injury | 
                            C00001165
                             | 
                        
| D053099 | Azotemia | 
                            C00001165
                             | 
                        
| D001929 | Brain Edema | 
                            C00001165
                             | 
                        
| D002545 | Brain Ischemia | 
                            C00001165
                             | 
                        
| D002543 | Cerebral Hemorrhage | 
                            C00001165
                             | 
                        
| D003128 | COMA | 
                            C00001165
                             | 
                        
| D003161 | Compartment Syndromes | 
                            C00001165
                             | 
                        
| D006259 | Craniocerebral Trauma | 
                            C00001165
                             | 
                        
| D003875 | Drug Eruptions | 
                            C00001165
                             | 
                        
| D064420 | Drug-Related Side Effects and Adverse Reactions | 
                            C00001165
                             | 
                        
| D004487 | Edema | 
                            C00001165
                             | 
                        
| D004660 | Encephalitis | 
                            C00001165
                             | 
                        
| D005901 | Glaucoma | 
                            C00001165
                             | 
                        
| D015812 | Glaucoma, Angle-Closure | 
                            C00001165
                             | 
                        
| D005910 | Glioma | 
                            C00001165
                             | 
                        
| D034381 | Hearing Loss | 
                            C00001165
                             | 
                        
| D006331 | Heart Diseases | 
                            C00001165
                             | 
                        
| D006505 | Hepatitis | 
                            C00001165
                             | 
                        
| D006955 | Hypernatremia | 
                            C00001165
                             | 
                        
| D007008 | Hypokalemia | 
                            C00001165
                             | 
                        
| D007010 | Hyponatremia | 
                            C00001165
                             | 
                        
| D007022 | Hypotension | 
                            C00001165
                             | 
                        
| D007177 | Inappropriate ADH Syndrome | 
                            C00001165
                             | 
                        
| D019586 | Intracranial Hypertension | 
                            C00001165
                             | 
                        
| D002546 | Ischemic Attack, Transient | 
                            C00001165
                             | 
                        
| D007674 | Kidney Diseases | 
                            C00001165
                             | 
                        
| D008579 | Meningioma | 
                            C00001165
                             | 
                        
| D017202 | Myocardial Ischemia | 
                            C00001165
                             | 
                        
| D009336 | Necrosis | 
                            C00001165
                             | 
                        
| D009401 | Nephrosis | 
                            C00001165
                             | 
                        
| D009422 | Nervous System Diseases | 
                            C00001165
                             | 
                        
| D009846 | Oliguria | 
                            C00001165
                             | 
                        
| D054038 | Posterior Leukoencephalopathy Syndrome | 
                            C00001165
                             | 
                        
| D011654 | Pulmonary Edema | 
                            C00001165
                             | 
                        
| D011655 | Pulmonary Embolism | 
                            C00001165
                             | 
                        
| D051437 | Renal Insufficiency | 
                            C00001165
                             | 
                        
| D015427 | Reperfusion Injury | 
                            C00001165
                             | 
                        
| D012769 | Shock | 
                            C00001165
                             | 
                        
| D020521 | Stroke | 
                            C00001165
                             | 
                        
| D014581 | Urticaria | 
                            C00001165
                             | 
                        
| D014693 | Ventricular Fibrillation | 
                            C00001165
                             |