Species

KNApSAcK Entry

Organism name Veronicastrum virginicum (L.) Farw.
Genus Veronicastrum
Family Plantaginaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Veronicastrum
Linked NCBI taxonomy ID 74694
Linked level genus

Family

Family in NCBI taxonomy Plantaginaceae
ID 156152

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (11)

Species Activity
Veronicastrum virginicum (L.) Farw. Antiseptic
Veronicastrum virginicum (L.) Farw. Carminative
Veronicastrum virginicum (L.) Farw. Cholagogue
Veronicastrum virginicum (L.) Farw. Choleretic
Veronicastrum virginicum (L.) Farw. Depurative
Veronicastrum virginicum (L.) Farw. Diaphoretic
Veronicastrum virginicum (L.) Farw. Emetic
Veronicastrum virginicum (L.) Farw. Hepatotonic
Veronicastrum virginicum (L.) Farw. Laxative
Veronicastrum virginicum (L.) Farw. Tonic
Veronicastrum virginicum (L.) Farw. toxic

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010600 External link 512 Ajugol
/ Leonuride
CHEMBL595516
No. 64 No. 36
C00003075 External link 512 Catalpol
CHEMBL513223
C078040
2 / 1 / 1 0 / 2 No. 64 No. 36
C00001165 External link 512 Mannitol
/ D-Mannitol
CHEMBL16105
CHEMBL689
CHEMBL1682
CHEMBL1735282
CHEMBL1773904
D008353
101 / 49 / 42 10 / 42 No. 630

Human Protein / Gene in interactions

101 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q92830 Histone acetyltransferase KAT2A Enzyme C00001165 C00003075 0 / 0
P03372 Estrogen receptor NR3A1 C00001165 C00003075 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00001165 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001165 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001165 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001165 2 / 2
P08246 Neutrophil elastase S1A C00001165 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001165 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001165 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001165 0 / 0
P29466 Caspase-1 C14 C00001165 0 / 0
P17252 Protein kinase C alpha type Alpha C00001165 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001165 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001165 2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter C00001165 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001165 11 / 10
P00918 Carbonic anhydrase 2 Lyase C00001165 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001165 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001165 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001165 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001165 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001165 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001165 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001165 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001165 0 / 0
P08183 Multidrug resistance protein 1 drug C00001165 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001165 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001165 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001165 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001165 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001165 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00001165 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001165 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001165 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001165 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001165 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001165 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001165 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001165 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001165 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001165 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001165 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001165 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001165 1 / 0
O75496 Geminin Unclassified protein C00001165 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001165 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001165 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001165 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001165 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001165 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001165 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001165 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001165 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001165 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001165 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001165 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001165 0 / 0
P08311 Cathepsin G S1A C00001165 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001165 1 / 0
P03956 Interstitial collagenase M10A C00001165 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001165 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001165 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001165 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001165 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001165 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001165 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001165 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001165 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001165 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001165 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001165 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001165 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001165 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001165 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001165 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001165 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001165 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001165 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001165 0 / 0
P10323 Acrosin S1A C00001165 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001165 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001165 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001165 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001165 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001165 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001165 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001165 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001165 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001165 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001165 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001165 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001165 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001165 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001165 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001165 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001165 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001165 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001165 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001165 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001165 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001165 1 / 1

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001165
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001165
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00001165
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001165
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001165
4878 NPPA, ANF, ANP, ATFB6, CDD-ANF, PND natriuretic peptide A C00001165
27250 PDCD4, H731 programmed cell death 4 (neoplastic transformation inhibitor) C00001165
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00001165
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00001165
7163 TPD52, D52, N8L, PC-1, PrLZ, hD52 tumor protein D52 C00001165

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (42)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

44 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007249 Inflammation C00003075
D019636 Neurodegenerative Diseases C00003075
D058186 Acute Kidney Injury C00001165
D055371 Acute Lung Injury C00001165
D053099 Azotemia C00001165
D001929 Brain Edema C00001165
D002545 Brain Ischemia C00001165
D002543 Cerebral Hemorrhage C00001165
D003128 COMA C00001165
D003161 Compartment Syndromes C00001165
D006259 Craniocerebral Trauma C00001165
D003875 Drug Eruptions C00001165
D064420 Drug-Related Side Effects and Adverse Reactions C00001165
D004487 Edema C00001165
D004660 Encephalitis C00001165
D005901 Glaucoma C00001165
D015812 Glaucoma, Angle-Closure C00001165
D005910 Glioma C00001165
D034381 Hearing Loss C00001165
D006331 Heart Diseases C00001165
D006505 Hepatitis C00001165
D006955 Hypernatremia C00001165
D007008 Hypokalemia C00001165
D007010 Hyponatremia C00001165
D007022 Hypotension C00001165
D007177 Inappropriate ADH Syndrome C00001165
D019586 Intracranial Hypertension C00001165
D002546 Ischemic Attack, Transient C00001165
D007674 Kidney Diseases C00001165
D008579 Meningioma C00001165
D017202 Myocardial Ischemia C00001165
D009336 Necrosis C00001165
D009401 Nephrosis C00001165
D009422 Nervous System Diseases C00001165
D009846 Oliguria C00001165
D054038 Posterior Leukoencephalopathy Syndrome C00001165
D011654 Pulmonary Edema C00001165
D011655 Pulmonary Embolism C00001165
D051437 Renal Insufficiency C00001165
D015427 Reperfusion Injury C00001165
D012769 Shock C00001165
D020521 Stroke C00001165
D014581 Urticaria C00001165
D014693 Ventricular Fibrillation C00001165