Persea gratissima
Species
KNApSAcK Entry
| Organism name | Persea gratissima |
|---|---|
| Genus | Persea |
| Family | Lauraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Persea americana |
|---|---|
| Linked NCBI taxonomy ID | 3435 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lauraceae |
|---|---|
| ID | 3433 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00009277
|
Proanthocyanidin A1
|
CHEMBL286933
CHEMBL81646 CHEMBL450916 |
13 / 3 / 4 | No. 16 | No. 19 |
|
||
|
C00009077
|
Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479580
|
20 / 7 / 8 | 10 / 0 | No. 16 | No. 19 |
|
|
C00009075
|
Procyanidin B1
/ Epicatechin-(4beta->8)-catechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479579
|
20 / 7 / 8 | No. 16 | No. 19 |
|
|
|
C00002934
|
Proanthocyanidin A2
/ Proanthocyanidin A-2 / (+)-Proanthocyanidin A-2 |
CHEMBL286933
CHEMBL81646 CHEMBL450916 |
C473740
|
13 / 3 / 4 | No. 16 | No. 19 |
|
|
|
C00000134
|
(s)-(+)-Abscisic acid
/ 2,4-Pentadienoic acid |
CHEMBL288040
CHEMBL379808 CHEMBL1318134 CHEMBL1469719 CHEMBL1741460 CHEMBL1965138 |
D000040
|
10 / 9 / 10 | No. 1435 | No. 38 |
|
|
|
C00002740
|
Estragol
/ Esdragol / Estragole |
CHEMBL470671
|
C007633
|
10 / 16 / 43 | 3 / 5 | No. 3933 | No. 6 |
|
|
C00002719
|
N-Caffeoylputrescine
|
No. 5072 |
|
|||||
|
C00002780
|
Subaphyllin
|
C065165
|
No. 5072 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00002934 C00009075 C00009077 C00009277 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00002934 C00009075 C00009077 C00009277 | 1 / 1 |
| Q05655 | Protein kinase C delta type | Delta | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00002934 C00009075 C00009077 C00009277 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00002934 C00009075 C00009077 C00009277 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000134 C00002740 C00009075 C00009077 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000134 C00009075 C00009077 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000134 C00009075 C00009077 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000134 C00009075 C00009077 | 0 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002740 C00009075 C00009077 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000134 C00009075 C00009077 | 0 / 0 |
| P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00009075 C00009077 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00009075 C00009077 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000134 C00002740 | 3 / 2 |
| P49763 | Placenta growth factor | Unclassified protein | C00002934 C00009277 | 0 / 0 |
| P15692 | Vascular endothelial growth factor A | Secreted protein | C00002934 C00009277 | 1 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00009075 C00009077 | 3 / 3 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002740 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002740 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002740 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00000134 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002740 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000134 | 3 / 4 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000134 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000134 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002740 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002740 | 7 / 37 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002740 | 2 / 0 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002740
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002740
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00002740
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00009077
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00009077
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00009077
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00009077
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00009077
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00009077
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00009077
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00009077
|
| 4240 | MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 | milk fat globule-EGF factor 8 protein |
C00009077
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00009077
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #603933 | Microvascular complications of diabetes, susceptibility to, 1; mvcd1 |
P15692
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P24723
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
P15692 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P15692 (marker) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|