Herbertus sakuraii
Species
KNApSAcK Entry
| Organism name | Herbertus sakuraii |
|---|---|
| Genus | Herbertus |
| Family | Herbertaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Herbertus sakuraii |
|---|---|
| Linked NCBI taxonomy ID | 537824 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Herbertaceae |
|---|---|
| ID | 56910 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Embryophyta |
|---|---|
| ID | 3193 |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003162
|
Longifolene
|
CHEMBL519092
|
C035607
|
No. 149 | No. 38 |
|
||
|
C00037340
|
Isoplagiochin D
|
CHEMBL515207
|
No. 299 |
|
||||
|
C00037339
|
Isoplagiochin C
/ (-)-Isoplagiochin C |
No. 299 |
|
|||||
|
C00031532
|
2,12-Dichloroisoplagiochin
/ 2,12-Dichloroisoplagiochin D |
No. 299 |
|
|||||
|
C00012541
|
Herbertene
/ Isocuparene / (-)-Herbertene / (-)-Isocuparene / (S)-1-Methyl-3-(1,2,2-trimethylcyclopentyl)benzene |
No. 309 |
|
|||||
|
C00036366
|
1,13-Dihydroxyherbertene
|
No. 309 |
|
|||||
|
C00012543
|
alpha-Herbertenol
/ 4-Hydroxyisocuparene / (-)-alpha-Herbertenol / (S)-4-Methyl-2-(1,2,2-trimethylcyclopentyl)phenol |
No. 309 |
|
|||||
|
C00036367
|
1,15-Dihydroxyherbertene
|
No. 309 |
|
|||||
|
C00036907
|
cis-Calamenene
|
No. 824 |
|
|||||
|
C00032002
|
Mastigophorene A
|
No. 2111 |
|
|||||
|
C00012549
|
Mastigophorene C
/ [S-(R*,R*)]-3-[[3,4-Dihydroxy-5-(1,2,2-trimethylcyclopentyl)phenyl]methyl]-4-methyl-6-(1,2,2-trimethylcyclopentyl)-1,2-benzenediol |
No. 2111 |
|
|||||
|
C00032003
|
Mastigophorene B
/ (-)-Mastigophorene B |
No. 2111 |
|
|||||
|
C00037264
|
Herbertenone A
/ (-)-Herbertenone A |
No. 3323 |
|
|||||
|
C00037265
|
Herbertenone B
/ (-)-Herbertenone B |
No. 3323 |
|
|||||
|
C00001259
|
Naphthalene
|
CHEMBL16293
|
C031721
|
6 / 5 / 4 | 43 / 18 | No. 5021 |
|
|
|
C00012546
|
Herbertenolide
/ (3aS-trans)-2,3,3a,9b-Tetrahydro-3a,8,9b-trimethylcyclopenta[c][1]benzopyran-4(1H)-one |
No. 6494 |
|
Human Protein / Gene in interactions
6 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P42574 | Caspase-3 | C14 | C00001259 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001259 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001259 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001259 | 2 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001259 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001259 | 3 / 4 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00001259
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001259
|
| 429 | ASCL1, ASH1, HASH1, MASH1, bHLHa46 | achaete-scute family bHLH transcription factor 1 |
C00001259
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001259
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001259
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001259
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001259
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00001259
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001259
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00001259
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001259
|
| 13107 |
C00001259
|
||
| 29785 | CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001259
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001259
|
| 2052 | EPHX1, EPHX, EPOX, HYL1, MEH | epoxide hydrolase 1, microsomal (xenobiotic) (EC:3.3.2.9) |
C00001259
|
| 2053 | EPHX2, CEH, SEH | epoxide hydrolase 2, cytoplasmic (EC:3.3.2.10 3.1.3.76) |
C00001259
|
| 2252 | FGF7, HBGF-7, KGF | fibroblast growth factor 7 |
C00001259
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00001259
|
| 2521 | FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS | fused in sarcoma |
C00001259
|
| 2642 | GCGR, GGR | glucagon receptor |
C00001259
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00001259
|
| 8870 | IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 | immediate early response 3 |
C00001259
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00001259
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001259
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00001259
|
| 3956 | LGALS1, GAL1, GBP | lectin, galactoside-binding, soluble, 1 |
C00001259
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00001259
|
| 4159 | MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL | melanocortin 3 receptor |
C00001259
|
| 4160 | MC4R | melanocortin 4 receptor |
C00001259
|
| 4161 | MC5R, MC2 | melanocortin 5 receptor |
C00001259
|
| 10403 | NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 | NDC80 kinetochore complex component |
C00001259
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00001259
|
| 5053 | PAH, PH, PKU, PKU1 | phenylalanine hydroxylase (EC:1.14.16.1) |
C00001259
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00001259
|
| 389 | RHOC, ARH9, ARHC, H9, RHOH9 | ras homolog family member C |
C00001259
|
| 7356 | SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1 | secretoglobin, family 1A, member 1 (uteroglobin) |
C00001259
|
| 6855 | SYP, MRXSYP | synaptophysin |
C00001259
|
| 6932 | TCF7, TCF-1 | transcription factor 7 (T-cell specific, HMG-box) |
C00001259
|
| 7076 | TIMP1, CLGI, EPA, EPO, HCI, TIMP | TIMP metallopeptidase inhibitor 1 |
C00001259
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001259
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #133239 | Esophageal cancer |
P18054
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG DISEASE (4)
| KEGG | name | UniProt |
|---|---|---|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
Diseases related to CTD interactions
18 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000014 | Abnormalities, Drug-Induced |
C00001259
|
| D058186 | Acute Kidney Injury |
C00001259
|
| D055371 | Acute Lung Injury |
C00001259
|
| D000743 | Anemia, Hemolytic |
C00001259
|
| D002386 | Cataract |
C00001259
|
| D006456 | Hemoglobinuria |
C00001259
|
| D006529 | Hepatomegaly |
C00001259
|
| D006959 | Hyperoxaluria |
C00001259
|
| D006965 | Hyperplasia |
C00001259
|
| D008114 | Liver Neoplasms, Experimental |
C00001259
|
| D055370 | Lung Injury |
C00001259
|
| D008175 | Lung Neoplasms |
C00001259
|
| D048629 | Micronuclei, Chromosome-Defective |
C00001259
|
| D009336 | Necrosis |
C00001259
|
| D009362 | Neoplasm Metastasis |
C00001259
|
| D011041 | Poisoning |
C00001259
|
| D014133 | Tracheal Diseases |
C00001259
|
| D015431 | Weight Loss |
C00001259
|