Astragalus bisulcatus
Species
KNApSAcK Entry
| Organism name | Astragalus bisulcatus |
|---|---|
| Genus | Astragalus |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Astragalus bisulcatus |
|---|---|
| Linked NCBI taxonomy ID | 20406 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001382
|
Se-methyl-L-selenocysteine
|
CHEMBL62382
CHEMBL1472699 |
C002979
|
16 / 8 / 6 | 37 / 6 | No. 2513 |
|
|
|
C00034232
|
Se-Methylselenocysteine
|
CHEMBL62382
CHEMBL1472699 |
16 / 8 / 6 | No. 2513 |
|
Human Protein / Gene in interactions
16 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001382 C00034232 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001382 C00034232 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001382 C00034232 | 2 / 0 |
| Q16773 | Kynurenine--oxoglutarate transaminase 1 | Enzyme | C00001382 C00034232 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001382 C00034232 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001382 C00034232 | 0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001382 C00034232 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001382 C00034232 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001382 C00034232 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001382 C00034232 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001382 C00034232 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001382 C00034232 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001382 C00034232 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001382 C00034232 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001382 C00034232 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001382 C00034232 | 0 / 0 |
37 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001382
|
| 54971 | BANP, BEND1, SMAR1, SMARBP1 | BTG3 associated nuclear protein |
C00001382
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001382
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001382
|
| 1066 | CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 | carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) |
C00001382
|
| 5119 | CHMP1A, CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A | charged multivesicular body protein 1A |
C00001382
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00001382
|
| 1278 | COL1A2, OI4 | collagen, type I, alpha 2 |
C00001382
|
| 1287 | COL4A5, ASLN, ATS, CA54 | collagen, type IV, alpha 5 |
C00001382
|
| 1291 | COL6A1, OPLL | collagen, type VI, alpha 1 |
C00001382
|
| 1294 | COL7A1, EBD1, EBDCT, EBR1 | collagen, type VII, alpha 1 |
C00001382
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001382
|
| 4733 | DRG1, NEDD3 | developmentally regulated GTP binding protein 1 |
C00001382
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00001382
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00001382
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00001382
|
| 2879 | GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx | glutathione peroxidase 4 (EC:1.11.1.12) |
C00001382
|
| 2897 | GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1 | glutamate receptor, ionotropic, kainate 1 |
C00001382
|
| 2899 | GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a | glutamate receptor, ionotropic, kainate 3 |
C00001382
|
| 3480 | IGF1R, CD221, IGFIR, IGFR, JTK13 | insulin-like growth factor 1 receptor (EC:2.7.10.1) |
C00001382
|
| 4288 | MKI67, KIA, MIB-1 | marker of proliferation Ki-67 |
C00001382
|
| 51734 | MSRB1, SELR, SELX, SEPX1, SepR | methionine sulfoxide reductase B1 (EC:1.8.4.-) |
C00001382
|
| 5033 | P4HA1, P4HA | prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) |
C00001382
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00001382
|
| 5865 | RAB3B | RAB3B, member RAS oncogene family |
C00001382
|
| 5867 | RAB4A, HRES-1/RAB4, RAB4 | RAB4A, member RAS oncogene family |
C00001382
|
| 949 | SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 | scavenger receptor class B, member 1 |
C00001382
|
| 9403 | SEP15 | 15 kDa selenoprotein |
C00001382
|
| 6414 | SEPP1, SELP, SeP | selenoprotein P, plasma, 1 |
C00001382
|
| 6415 | SEPW1, selW | selenoprotein W, 1 |
C00001382
|
| 6519 | SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
C00001382
|
| 8773 | SNAP23, HsT17016, SNAP-23, SNAP23A, SNAP23B | synaptosomal-associated protein, 23kDa |
C00001382
|
| 6272 | SORT1, Gp95, LDLCQ6, NT3 | sortilin 1 |
C00001382
|
| 393515 |
C00001382
|
||
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00001382
|
| 54952 | TRNAU1AP, PRO1902, RP4-669K10.4, SECP43, TRSPAP1 | tRNA selenocysteine 1 associated protein 1 |
C00001382
|
| 7507 | XPA, XP1, XPAC | xeroderma pigmentosum, complementation group A |
C00001382
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
KEGG DISEASE (6)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001943 | Breast Neoplasms |
C00001382
|
| D056486 | Drug-Induced Liver Injury |
C00001382
|
| D006943 | Hyperglycemia |
C00001382
|
| D007003 | Hypoglycemia |
C00001382
|
| D007673 | Kidney Cortex Necrosis |
C00001382
|
| D008325 | Mammary Neoplasms, Experimental |
C00001382
|