PCIDB

Aristolochia mollissima

Species

KNApSAcK Entry

Organism name Aristolochia mollissima
Genus Aristolochia
Family Aristolochiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aristolochia mollissima
Linked NCBI taxonomy ID 158558
Linked level species

Family

Family in NCBI taxonomy Aristolochiaceae
ID 16727

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027141 External link 512 Noraristolodione
/ Dioxodehydroasimilobine
/ 4,5-Dioxodehydroasimilobine
CHEMBL390369
No. 125
C00027288 External link 512 Aristoliukine B
No. 125
C00025787 External link 512 Cepharadione A
CHEMBL235921
No. 125
C00027121 External link 512 Aristolactam AII
/ Aristololactam A II
CHEMBL390368
No. 125
C00027122 External link 512 Aristolactam AIIIa
CHEMBL388956
5 / 1 / 3 No. 125
C00027287 External link 512 Aristoliukine A
No. 125
C00001526 External link 512 Aristolochic acid I
/ Aristolochic acid A
CHEMBL93353
C000228
13 / 11 / 12 21 / 10 No. 291 No. 4
C00027125 External link 512 Aristolochic acid D
/ Aristolochic acid IVa
CHEMBL604748
3 / 0 / 0 No. 291 No. 4
C00021671 External link 512 Aristolochic acid B
/ Aristolochic acid II
CHEMBL602280
C042310
1 / 0 / 0 No. 291 No. 4
C00027418 External link 512 N-cis-Coumaroyltyramine
/ N-p-cis-Coumaroyltyramine
/ cis-N-p-Coumaroyltyramine
CHEMBL64286
No. 499
C00027291 External link 512 Aristoloterpenate I
/ (-)-Aristoloterpenate I
CHEMBL505464
CHEMBL508460
No. 1255
C00027293 External link 512 Aristophyllide A
CHEMBL449419
CHEMBL448051
No. 1255
C00027292 External link 512 Aristoloterpenate III
/ (-)-Aristoloterpenate III
CHEMBL505464
CHEMBL508460
No. 1255
C00027286 External link 512 Aristolactam I N-beta-glucoside
C062008
No. 1580
C00027123 External link 512 Aristolactam Ia N-beta-glucoside
/ Aristolactam C N-beta-D-glucoside
/ Aristolactam-Ia-N-beta-D-glucoside
/ Aristolactam Ia N-beta-D-glucopyranoside
No. 1580

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P24941 Cyclin-dependent kinase 2 Cdc2 C00001526 C00021671 C00027122 C00027125 0 / 0
O75496 Geminin Unclassified protein C00001526 C00027125 0 / 0
Q96GD4 Aurora kinase B Aur C00027122 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001526 4 / 1
P06493 Cyclin-dependent kinase 1 Cdc2 C00027122 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001526 0 / 0
P39748 Flap endonuclease 1 Enzyme C00027125 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001526 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001526 0 / 0
O14965 Aurora kinase A Aur C00027122 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001526 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001526 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001526 0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00027122 1 / 3
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00001526 0 / 0
O00255 Menin Unclassified protein C00001526 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001526 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001526 0 / 0

21 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00001526
655 BMP7, OP-1 bone morphogenetic protein 7 C00001526
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001526
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00001526
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001526
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001526
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00001526
1965 EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa C00001526
2034 EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 endothelial PAS domain protein 1 C00001526
26585 GREM1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2 gremlin 1, DAN family BMP antagonist C00001526
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00001526
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001526
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001526
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00001526
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00001526
9376 SLC22A8, OAT3 solute carrier family 22 (organic anion transporter), member 8 C00001526
4086 SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 SMAD family member 1 C00001526
4090 SMAD5, DWFC, JV5-1, MADH5 SMAD family member 5 C00001526
4093 SMAD9, MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B SMAD family member 9 C00001526
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001526
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00001526

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (15)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00030 Cervical cancer P11802 (related)
H00038 Malignant melanoma P11802 (related)
H00042 Glioma P11802 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001284 Atrophy C00001526
D001449 Balkan Nephropathy C00001526
D018376 Cardiovascular Abnormalities C00001526
D007249 Inflammation C00001526
D007674 Kidney Diseases C00001526
D007680 Kidney Neoplasms C00001526
D007683 Kidney Tubular Necrosis, Acute C00001526
D009369 Neoplasms C00001526
D051437 Renal Insufficiency C00001526
D014571 Urologic Neoplasms C00001526