Species

KNApSAcK Entry

Organism name Aglaia forbesii
Genus Aglaia
Family Meliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aglaia forbesii
Linked NCBI taxonomy ID 306504
Linked level species

Family

Family in NCBI taxonomy Meliaceae
ID 43707

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019220 External link 512 Lupenone
CHEMBL486393
CHEMBL575188
3 / 4 / 2 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00028187 External link 512 Didesmethylrocaglamide
CHEMBL583207
1 / 0 / 0 No. 449
C00027821 External link 512 Aglain B
/ (+)-Aglain B
CHEMBL390463
No. 576
C00027819 External link 512 Aglaforbesin B
No. 576
C00027820 External link 512 Aglain A
/ (+)-Aglain A
CHEMBL390233
No. 576
C00027818 External link 512 Aglaforbesin A
No. 576
C00033769 External link 512 Desacetylpyramidaglain D
/ (+)-Desacetylpyramidaglain D
CHEMBL2204410
No. 576
C00033767 External link 512 Desacetylpyramidaglain A
/ (+)-Desacetylpyramidaglain A
CHEMBL2204410
No. 576
C00033768 External link 512 Desacetylpyramidaglain C
/ (-)-Desacetylpyramidaglain C
CHEMBL2204410
No. 576
C00033545 External link 512 23,24,25-Trihydroxycycloartan-3-one
/ (+)-23,24,25-Trihydroxycycloartan-3-one
No. 804
C00033550 External link 512 2beta,3beta-Dihydroxy-5alpha-pregn-17(E)-en-16-one
/ (-)-2beta,3beta-Dihydroxy-5alpha-pregn-17(E)-en-16-one
No. 1223
C00033551 External link 512 2beta,3beta-Dihydroxy-5alpha-pregn-17(Z)-en-16-one
No. 1223
C00000149 External link 512 Spathulenol
CHEMBL518542
CHEMBL1774433
C013258
No. 1603
C00034182 External link 512 Pyramidatine
CHEMBL483414
No. 2973

Human Protein / Gene in interactions

7 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00019220 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00028187 0 / 0
P14679 Tyrosinase Oxidoreductase C00019220 4 / 2
Q96RI1 Bile acid receptor NR1H4 C00019220 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (2)

KEGG name UniProt
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749