PCIDB

Strychnos aculeata

Species

KNApSAcK Entry

Organism name Strychnos aculeata
Genus Strychnos
Family Longaniaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Strychnos aculeata
Linked NCBI taxonomy ID 1040854
Linked level species

Family

Family in NCBI taxonomy Loganiaceae
ID 26468

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001695 External link 512 Brucine
CHEMBL501756
CHEMBL1333042
CHEMBL1515857
CHEMBL1573549
CHEMBL2361237
C083806
11 / 24 / 21 11 / 8 No. 672 No. 4

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00001695 4 / 1
P02545 Prelamin-A/C Unclassified protein C00001695 11 / 10
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001695 0 / 0
O75496 Geminin Unclassified protein C00001695 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001695 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001695 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001695 1 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001695 3 / 3
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001695 0 / 0
O00255 Menin Unclassified protein C00001695 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001695 1 / 2

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00001695
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001695
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001695
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001695
1128 CHRM1, HM1, M1, M1R cholinergic receptor, muscarinic 1 C00001695
1129 CHRM2, HM2 cholinergic receptor, muscarinic 2 C00001695
1131 CHRM3, EGBRS, HM3 cholinergic receptor, muscarinic 3 C00001695
1132 CHRM4, HM4, M4R cholinergic receptor, muscarinic 4 C00001695
2741 GLRA1, HKPX1, STHE glycine receptor, alpha 1 C00001695
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001695
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001695

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (21)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00001695
D000741 Anemia, Aplastic C00001695
D002294 Carcinoma, Squamous Cell C00001695
D002493 Central Nervous System Diseases C00001695
D008113 Liver Neoplasms C00001695
D009101 Multiple Myeloma C00001695
D009374 Neoplasms, Experimental C00001695
D012206 Rhabdomyolysis C00001695