| Organism name | Thalictrum acutifolium | 
|---|---|
| Genus | Thalictrum | 
| Family | Ranunculaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Thalictrum acutifolium | 
|---|---|
| Linked NCBI taxonomy ID | 1277762 | 
| Linked level | species | 
| Family in NCBI taxonomy | Ranunculaceae | 
|---|---|
| ID | 3440 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | eudicotyledons | 
|---|---|
| ID | 71240 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00001790   | Actinodaphnine / (+)-Actinodaphnine / 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine | CHEMBL518088 CHEMBL1588263 | C060992 | 30 / 32 / 24 | No. 20 | No. 4 |   | |
| C00027807   | Acutifolidine | No. 20 | No. 4 |   | ||||
| C00025997   | Berlambine / Oxyberberine / 8-Oxoberberine | CHEMBL11531 | No. 439 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00001790 | 0 / 0 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001790 | 4 / 1 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001790 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00001790 | 1 / 1 | 
| P06746 | DNA polymerase beta | Enzyme | C00001790 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001790 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00001790 | 11 / 10 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001790 | 1 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001790 | 0 / 0 | 
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001790 | 2 / 2 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00001790 | 0 / 0 | 
| P42858 | Huntingtin | Unclassified protein | C00001790 | 1 / 1 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001790 | 2 / 0 | 
| O75496 | Geminin | Unclassified protein | C00001790 | 0 / 0 | 
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001790 | 0 / 0 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00001790 | 1 / 1 | 
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001790 | 0 / 0 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001790 | 1 / 2 | 
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00001790 | 0 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001790 | 2 / 2 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001790 | 0 / 0 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001790 | 0 / 0 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001790 | 0 / 0 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001790 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001790 | 4 / 3 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001790 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001790 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001790 | 0 / 0 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001790 | 1 / 0 | 
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001790 | 2 / 1 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #114500 | Colorectal cancer; crc | P84022 Q14191 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #137800 | Glioma susceptibility 1; glm1 | O75874 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #143100 | Huntington disease; hd | P42858 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #257200 | Niemann-pick disease, type a | P17405 | 
| #607616 | Niemann-pick disease, type b | P17405 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #172700 | Pick disease of brain | P10636 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #277700 | Werner syndrome; wrn | Q14191 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00137 | Niemann-Pick disease (NPD) typeA and B | P17405
                            (related) | 
| H00424 | Defects in the degradation of sphingomyelin | P17405
                            (related) | 
| H00059 | Huntington's disease (HD) | P42858
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q03164
                            (related) Q03164 (marker) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00296 | Defects in RecQ helicases | Q14191
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) |