PCIDB

Corydalis sempervirens

Species

KNApSAcK Entry

Organism name Corydalis sempervirens
Genus Corydalis
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Capnoides sempervirens
Linked NCBI taxonomy ID 3464
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001820 External link 512 Bucuculline
/ Bicucullin
/ (+)-Bicuculline
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
D001640
30 / 28 / 20 0 / 21 No. 605 No. 4
C00001830 External link 512 Capnoidine
/ l-Adlumidine
/ l-Capnoidine
/ (-)-Adlumidine
/ (-)-Capnoidine
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
30 / 28 / 20 No. 605 No. 4
C00027268 External link 512 Adlumiceine
No. 2202 No. 4

Human Protein / Gene in interactions

30 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001820 C00001830 1 / 0
P02545 Prelamin-A/C Unclassified protein C00001820 C00001830 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001820 C00001830 3 / 2
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001820 C00001830 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001820 C00001830 0 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001820 C00001830 0 / 0
O75496 Geminin Unclassified protein C00001820 C00001830 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001820 C00001830 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001820 C00001830 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001820 C00001830 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001820 C00001830 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001820 C00001830 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001820 C00001830 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001820 C00001830 1 / 0
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001820 C00001830 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001820 C00001830 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001820 C00001830 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001820 C00001830 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001820 C00001830 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001820 C00001830 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001820 C00001830 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001820 C00001830 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001820 C00001830 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001820 C00001830 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001820 C00001830 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001820 C00001830 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001820 C00001830 1 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001820 C00001830 3 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#103780 Alcohol dependence P47869
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#607208 Dravet syndrome P18507
P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250

KEGG DISEASE (20)

KEGG name UniProt
H00783 Febrile seizures O14764 (related)
P18507 (related)
P35498 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00001820
D000648 Amnesia, Retrograde C00001820
D001008 Anxiety Disorders C00001820
D001919 Bradycardia C00001820
D002375 Catalepsy C00001820
D004487 Edema C00001820
D004827 Epilepsy C00001820
D005119 Extravasation of Diagnostic and Therapeutic Materials C00001820
D006930 Hyperalgesia C00001820
D006973 Hypertension C00001820
D007022 Hypotension C00001820
D009069 Movement Disorders C00001820
D009207 Myoclonus C00001820
D009436 Neural Tube Defects C00001820
D020078 Neurogenic Inflammation C00001820
D020336 Paraparesis, Spastic C00001820
D010409 Penile Diseases C00001820
D049188 Prenatal Injuries C00001820
D012640 Seizures C00001820
D013035 Spasm C00001820
D013226 Status Epilepticus C00001820