Species

KNApSAcK Entry

Organism name Curarea candicans Barneby & Kurkoff
Genus Curarea
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Curarea
Linked NCBI taxonomy ID 461575
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001870 External link 512 Isobebeerin
/ Isobebeerine
/ Isochondodendrine
CHEMBL509310
CHEMBL1169628
No. 10 No. 4
C00025320 External link 512 Limacine
/ (-)-Limacine
CHEMBL504256
CHEMBL509803
CHEMBL500614
12 / 6 / 3 No. 10 No. 4
C00025321 External link 512 Limacine 2'-beta-N-oxide
/ (-)-Limacine 2'-beta-N-oxide
No. 10 No. 4
C00025613 External link 512 (-)-Krukovine
CHEMBL500609
CHEMBL452895
CHEMBL492604
CHEMBL1976284
No. 10 No. 4
C00025614 External link 512 (-)-Limacine 2'-alpha-N-oxide
No. 10 No. 4
C00025615 External link 512 (-)-Limacine, 2-beta-N-oxide
No. 10 No. 4
C00025649 External link 512 (+)-Candicusine
/ (+)-12-O-Demethyllimacusine
CHEMBL504525
CHEMBL508781
6 / 2 / 3 No. 10 No. 4
C00025668 External link 512 (+)-Limacusine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025649 1 / 0
Q99700 Ataxin-2 Unclassified protein C00025320 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00025320 1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00025320 0 / 1
P08183 Multidrug resistance protein 1 drug C00025320 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025649 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00025320 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00025649 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025320 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025320 2 / 0
O75496 Geminin Unclassified protein C00025320 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025320 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025649 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025649 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025649 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00025320 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025320 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025320 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG name UniProt
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)