Species

KNApSAcK Entry

Organism name Cyclea hypoglauca Diels
Genus Cyclea
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cyclea
Linked NCBI taxonomy ID 152372
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001870 External link 512 Isobebeerin
/ Isobebeerine
/ Isochondodendrine
CHEMBL509310
CHEMBL1169628
No. 10 No. 4
C00025602 External link 512 l-Curine
/ (-)-Curine
/ l-Bebeerine
/ Aristolochine
/ (-)-Bebeerine
/ Aristolochine(C36 alkaloid)
CHEMBL1169627
13 / 6 / 5 No. 10 No. 4
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025901 External link 512 Insularine
/ O-Methylinsulanoline
No. 10 No. 4

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00025602 C00025604 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00025602 C00025604 0 / 0
O75496 Geminin Unclassified protein C00025602 C00025604 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025602 0 / 0
P42858 Huntingtin Unclassified protein C00025602 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00025602 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00025602 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025604 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025602 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025602 4 / 3
O43603 Galanin receptor type 2 Galanin receptor C00025602 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025602 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025602 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025602 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (5)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)