PCIDB

Siparuna griseo-flavescens

Species

KNApSAcK Entry

Organism name Siparuna griseo-flavescens
Genus Siparuna
Family Monimiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Siparuna
Linked NCBI taxonomy ID 63803
Linked level genus

Family

Family in NCBI taxonomy Siparunaceae
ID 104773

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00025675 External link 512 Lauroscholtzine
/ 2-O-Methylboldine
/ N-Methyllaurotetanine
/ (+)-N-Methyllaurotetanine
CHEMBL464099
1 / 1 / 0 No. 20 No. 4
C00027566 External link 512 Nandigerine
/ Hernangerine
/ (+)-Nandigerine
/ (+)-Hernangerine
CHEMBL1190170
No. 20 No. 4

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 1 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001872 0 / 0
O75496 Geminin Unclassified protein C00001872 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
P22303 Acetylcholinesterase Hydrolase C00025231 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025675 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#614674 Periodic fever, menstrual cycle-dependent P08908
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#112100 Yt blood group antigen P22303

KEGG DISEASE (10)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)