PCIDB

Polyalthia cerasoides

Species

KNApSAcK Entry

Organism name Polyalthia cerasoides
Genus Polyalthia
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hubera cerasoides
Linked NCBI taxonomy ID 235797
Linked level species

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00028454 External link 512 Laudanosine
CHEMBL1407
CHEMBL519894
CHEMBL1613
18 / 26 / 21 No. 345 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00001875 External link 512 Tritopin
/ Tritopine
/ Laudanidine
/ (-)-Laudanidine
CHEMBL251625
CHEMBL1425007
2 / 0 / 0 No. 345 No. 4
C00025654 External link 512 Codamine
/ (+)-Codamine
/ L-(+)-Codamine
/ (S)-(+)-Codamine
CHEMBL251624
No. 345 No. 4
C00038593 External link 512 Bidebiline E
CHEMBL400245
No. 796
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00027529 External link 512 Cerasonine
No. 2972
C00027528 External link 512 Cerasodine
No. 2972

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001875 C00028454 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00028454 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00028454 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00028454 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00028454 2 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00028454 0 / 0
O75496 Geminin Unclassified protein C00001875 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00028454 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00028454 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00028454 0 / 0
P02545 Prelamin-A/C Unclassified protein C00028454 11 / 10
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00028454 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00028454 3 / 3
P22303 Acetylcholinesterase Hydrolase C00028454 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00028454 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00028454 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00028454 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00028454 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00028454 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#112100 Yt blood group antigen P22303

KEGG DISEASE (21)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)