Species

KNApSAcK Entry

Organism name Papaver macrostomum
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver macrostomum
Linked NCBI taxonomy ID 357472
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025460 External link 512 Porphyroxine
/ Papaverrubine D
No. 305
C00001911 External link 512 Rhoeadine
C019078
No. 305
C00025457 External link 512 Papaverrubin A
/ Papaverrubine A
/ N-Demethylisorheadine
No. 305
C00025458 External link 512 Papaverrubine B
/ O-Methylporphyroxine
No. 305
C00025464 External link 512 Rhoeagenine
No. 305
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00029004 External link 512 Sevanine
No. 1137
C00028538 External link 512 Macrostomine
No. 5590
C00028141 External link 512 Dehydromacrostomine
No. 5590

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001906 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001906 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001906 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001906 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (4)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)