Piper acutisleginum
Species
KNApSAcK Entry
| Organism name | Piper acutisleginum |
|---|---|
| Genus | Piper |
| Family | Piperaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Piper |
|---|---|
| Linked NCBI taxonomy ID | 13215 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Piperaceae |
|---|---|
| ID | 16739 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00025787
|
Cepharadione A
|
CHEMBL235921
|
No. 125 |
|
||||
|
C00042857
|
Piperlonguminine
|
CHEMBL249652
CHEMBL253973 CHEMBL254178 |
8 / 5 / 3 | No. 638 |
|
|||
|
C00002065
|
Piperine
/ Bioperine / 1-Piperoylpiperidine |
CHEMBL43185
CHEMBL1395862 |
32 / 47 / 64 | No. 4209 | No. 1 |
|
Human Protein / Gene in interactions
47 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002065 C00003672 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002065 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002065 C00003672 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002065 C00042857 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002065 C00003672 | 0 / 0 |
| Q8NER1 | Transient receptor potential cation channel subfamily V member 1 | TRPV (Vanilloid) | C00002065 C00042857 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002065 C00042857 | 4 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002065 C00003672 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00002065 C00003672 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002065 C00003672 | 3 / 2 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002065 | 11 / 10 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002065 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002065 | 1 / 1 |
| Q13547 | Histone deacetylase 1 | Hydrolase | C00042857 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002065 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002065 | 2 / 2 |
| O75496 | Geminin | Unclassified protein | C00042857 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002065 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002065 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002065 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002065 | 0 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002065 | 5 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002065 | 0 / 0 |
| O15379 | Histone deacetylase 3 | Hydrolase | C00042857 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002065 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002065 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002065 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002065 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002065 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002065 | 4 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002065 | 7 / 37 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002065 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002065 | 0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00002065 | 0 / 0 |
| Q9UBN7 | Histone deacetylase 6 | Hydrolase | C00042857 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002065 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00042857 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (61)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (69)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|