PCIDB

Pyrenacantha klaineana

Species

KNApSAcK Entry

Organism name Pyrenacantha klaineana
Genus Pyrenacantha
Family Icacinaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pyrenacantha
Linked NCBI taxonomy ID 85254
Linked level genus

Family

Family in NCBI taxonomy Icacinaceae
ID 4321

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002145 External link 512 Camptothecin
CHEMBL65
CHEMBL276820
CHEMBL71836
D002166
140 / 99 / 97 79 / 11 No. 3696 No. 7

Human Protein / Gene in interactions

140 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002145 1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00002145 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002145 7 / 37
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002145 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002145 4 / 1
Q99700 Ataxin-2 Unclassified protein C00002145 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002145 2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002145 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002145 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002145 2 / 2
P08246 Neutrophil elastase S1A C00002145 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00002145 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002145 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002145 0 / 0
P04062 Glucosylceramidase Enzyme C00002145 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00002145 1 / 1
P29466 Caspase-1 C14 C00002145 0 / 0
P17252 Protein kinase C alpha type Alpha C00002145 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002145 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002145 2 / 2
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00002145 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002145 11 / 10
Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 Pek C00002145 1 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00002145 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00002145 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002145 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002145 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002145 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002145 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002145 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002145 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002145 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002145 0 / 0
P02768 Serum albumin Secreted protein C00002145 0 / 0
P08183 Multidrug resistance protein 1 drug C00002145 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002145 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002145 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002145 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002145 0 / 1
P54132 Bloom syndrome protein Enzyme C00002145 1 / 2
Q9HBX9 Relaxin receptor 1 Relaxin receptor C00002145 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002145 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002145 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00002145 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00002145 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00002145 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002145 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002145 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002145 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002145 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002145 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002145 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002145 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002145 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002145 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002145 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00002145 4 / 4
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002145 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002145 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002145 0 / 0
P42858 Huntingtin Unclassified protein C00002145 1 / 1
O75496 Geminin Unclassified protein C00002145 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002145 0 / 0
P09651 Heterogeneous nuclear ribonucleoprotein A1 Unclassified protein C00002145 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002145 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002145 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002145 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002145 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002145 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002145 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002145 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002145 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002145 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002145 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002145 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002145 0 / 0
P08311 Cathepsin G S1A C00002145 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002145 1 / 0
P03956 Interstitial collagenase M10A C00002145 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002145 0 / 0
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00002145 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002145 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002145 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002145 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002145 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002145 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002145 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002145 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002145 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002145 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002145 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002145 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002145 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002145 1 / 1
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002145 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002145 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002145 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002145 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002145 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002145 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00002145 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002145 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002145 0 / 0
P03372 Estrogen receptor NR3A1 C00002145 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002145 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002145 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002145 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002145 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002145 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002145 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002145 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002145 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002145 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002145 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00002145 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002145 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002145 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002145 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002145 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002145 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00002145 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002145 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002145 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002145 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002145 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002145 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002145 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002145 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002145 0 / 0
O14746 Telomerase reverse transcriptase Enzyme C00002145 5 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002145 0 / 0
P40225 Thrombopoietin Unclassified protein C00002145 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002145 0 / 0
O00255 Menin Unclassified protein C00002145 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002145 1 / 2
P30874 Somatostatin receptor type 2 Somatostatin receptor C00002145 0 / 0
P31391 Somatostatin receptor type 4 Somatostatin receptor C00002145 0 / 0
P32745 Somatostatin receptor type 3 Somatostatin receptor C00002145 0 / 0
P35346 Somatostatin receptor type 5 Somatostatin receptor C00002145 0 / 0
P30872 Somatostatin receptor type 1 Somatostatin receptor C00002145 0 / 0

79 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002145
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002145
375790 AGRN agrin C00002145
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00002145
307 ANXA4, ANX4, PIG28, ZAP36 annexin A4 C00002145
581 BAX, BCL2L4 BCL2-associated X protein C00002145
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002145
637 BID, FP497 BH3 interacting domain death agonist C00002145
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00002145
672 BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 breast cancer 1, early onset C00002145
675 BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2 breast cancer 2, early onset C00002145
51719 CAB39, MO25 calcium binding protein 39 C00002145
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00002145
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002145
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002145
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002145
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002145
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00002145
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00002145
891 CCNB1, CCNB cyclin B1 C00002145
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002145
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002145
634 CEACAM1, BGP, BGP1, BGPI carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) C00002145
10153 CEBPZ, CBF, CBF2, HSP-CBF, NOC1 CCAAT/enhancer binding protein (C/EBP), zeta C00002145
1508 CTSB, APPS, CPSB cathepsin B (EC:3.4.22.1) C00002145
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002145
1806 DPYD, DHP, DHPDHASE, DPD dihydropyrimidine dehydrogenase (EC:1.3.1.2) C00002145
9538 EI24, EPG4, PIG8, TP53I8 etoposide induced 2.4 C00002145
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00002145
9852 EPM2AIP1 EPM2A (laforin) interacting protein 1 C00002145
2067 ERCC1, COFS4, RAD10, UV20 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) C00002145
2072 ERCC4, ERCC11, FANCQ, RAD1, XPF excision repair cross-complementing rodent repair deficiency, complementation group 4 C00002145
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00002145
2232 FDXR, ADXR ferredoxin reductase (EC:1.18.1.6) C00002145
2395 FXN, CyaY, FA, FARR, FRDA, X25 frataxin (EC:1.16.3.1) C00002145
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00002145
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00002145
3183 HNRNPC, C1, C2, HNRNP, HNRPC, SNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2) C00002145
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00002145
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00002145
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002145
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00002145
3956 LGALS1, GAL1, GBP lectin, galactoside-binding, soluble, 1 C00002145
5606 MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2 mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) C00002145
4217 MAP3K5, ASK1, MAPKKK5, MEKK5 mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25) C00002145
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002145
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00002145
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00002145
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002145
406929 MIR138-1, MIRN138-1 microRNA 138-1 C00002145
8440 NCK2, GRB4, NCKbeta NCK adaptor protein 2 C00002145
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002145
1263 PLK3, CNK, FNK, PRK polo-like kinase 3 (EC:2.7.11.21) C00002145
84152 PPP1R1B, DARPP-32, DARPP32 protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16) C00002145
9055 PRC1, ASE1 protein regulator of cytokinesis 1 C00002145
5888 RAD51, BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA RAD51 recombinase C00002145
5889 RAD51C, BROVCA3, FANCO, R51H3, RAD51L2 RAD51 paralog C C00002145
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002145
5933 RBL1, CP107, PRB1, p107 retinoblastoma-like 1 (p107) C00002145
5934 RBL2, P130, Rb2 retinoblastoma-like 2 (p130) C00002145
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002145
6382 SDC1, CD138, SDC, SYND1, syndecan syndecan 1 C00002145
6606 SMN1, BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16A survival of motor neuron 1, telomeric C00002145
55512 SMPD3, NSMASE2 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (EC:3.1.4.12) C00002145
6667 SP1 Sp1 transcription factor C00002145
6670 SP3, SPR2 Sp3 transcription factor C00002145
6890 TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) C00002145
30851 TAX1BP3, TIP-1 Tax1 (human T-cell leukemia virus type I) binding protein 3 C00002145
55775 TDP1 tyrosyl-DNA phosphodiesterase 1 (EC:3.1.4.-) C00002145
7057 THBS1, THBS, THBS-1, TSP, TSP-1, TSP1 thrombospondin 1 C00002145
8744 TNFSF9, 4-1BB-L, CD137L tumor necrosis factor (ligand) superfamily, member 9 C00002145
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00002145
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002145
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00002145
11257 TP53TG1, LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1 TP53 target 1 (non-protein coding) C00002145
7298 TYMS, HST422, TMS, TS thymidylate synthetase (EC:2.1.1.45) C00002145
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002145
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002145
7518 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 C00002145

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (99)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#609135 Aplastic anemia O14746
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#226980 Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus Q9NZJ5
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (97)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P00533 (related)
P04626 (related)
P04637 (related)
P68871 (marker)
H00024 Prostate cancer O14746 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q9NZJ5 (related)
H00766 Wolcott-Rallison syndrome Q9NZJ5 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003967 Diarrhea C00002145
D005621 Friedreich Ataxia C00002145
D005910 Glioma C00002145
D018316 Gliosarcoma C00002145
D006816 Huntington Disease C00002145
D007945 Leukemia, Lymphoid C00002145
D007968 Leukoencephalopathy, Progressive Multifocal C00002145
D009369 Neoplasms C00002145
D009374 Neoplasms, Experimental C00002145
D009503 Neutropenia C00002145
D024801 Tauopathies C00002145