Species

KNApSAcK Entry

Organism name Chrysanthemum cinerariifolium
Genus Chrysanthemum
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tanacetum cinerariifolium
Linked NCBI taxonomy ID 118510
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004150 External link 512 Apigenin 4'-glucuronide
No. 2 No. 15
C00004694 External link 512 Centaureidin
/ Desmethoxycentaureidine
/ Quercetagetin 3,4',6-trimethyl ether
/ 5,7,3'-Trihydroxy-3,6,4'-trimethoxyflavone
/ 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL77552
C083161
24 / 14 / 6 No. 3 No. 15
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00003357 External link 512 Pyrethrosin
CHEMBL517337
CHEMBL1698863
CHEMBL1968658
C003255
12 / 17 / 13 No. 843 No. 38
C00000236 External link 512 Pyrethrosine
No. 8053

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000601 C00003357 C00004694 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 C00003357 C00004694 2 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 C00003357 C00004694 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 C00003357 2 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 C00003357 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 C00003357 7 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 C00003357 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 C00003357 1 / 1
Q99700 Ataxin-2 Unclassified protein C00003357 C00004694 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P39748 Flap endonuclease 1 Enzyme C00004694 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004694 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003357 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00004694 2 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 0 / 1
P38398 Breast cancer type 1 susceptibility protein Enzyme C00003357 4 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00004694 1 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004694 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004694 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004694 1 / 0
P04350 Tubulin beta-4A chain Structural C00004694 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004694 0 / 0
P07437 Tubulin beta chain Structural C00004694 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004694 1 / 1
P68371 Tubulin beta-4B chain Structural C00004694 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004694 2 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004694 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00003357 0 / 3
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00004694 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004694 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004694 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004694 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004694 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004694 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300200 Adrenal hypoplasia, congenital; ahc P51843
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (26)

KEGG name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601