Orthosiphon aristatus
Species
KNApSAcK Entry
| Organism name | Orthosiphon aristatus |
|---|---|
| Genus | Orthosiphon |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Orthosiphon aristatus |
|---|---|
| Linked NCBI taxonomy ID | 204151 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (17)
| Species | Activity |
|---|---|
| Orthosiphon aristatus (Blume) Miq. | Antibacterial |
| Orthosiphon aristatus (Blume) Miq. | Anticancer |
| Orthosiphon aristatus (Blume) Miq. | Antiedemic |
| Orthosiphon aristatus (Blume) Miq. | Antiinflammatory |
| Orthosiphon aristatus (Blume) Miq. | Antiseptic |
| Orthosiphon aristatus (Blume) Miq. | Antispasmodic |
| Orthosiphon aristatus (Blume) Miq. | Aquaretic |
| Orthosiphon aristatus (Blume) Miq. | Astringent |
| Orthosiphon aristatus (Blume) Miq. | Choleretic |
| Orthosiphon aristatus (Blume) Miq. | Diuretic |
| Orthosiphon aristatus (Blume) Miq. | Glycogenic |
| Orthosiphon aristatus (Blume) Miq. | Hypertensive |
| Orthosiphon aristatus (Blume) Miq. | Hypoglycemic |
| Orthosiphon aristatus (Blume) Miq. | Insulin-Sparing |
| Orthosiphon aristatus (Blume) Miq. | Saluretic |
| Orthosiphon aristatus (Blume) Miq. | Sympathicolytic |
| Orthosiphon aristatus (Blume) Miq. | Uricosuric |
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003894
|
Eupatorin
/ 3',5-Dihydroxy-4',6,7-trimethoxyflavone / 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL487402
|
C103110
|
5 / 5 / 4 | 5 / 0 | No. 3 | No. 15 |
|
|
C00013596
|
Sinensetin
/ Pedalitin permethyl ether / 5,6,7,3',4'-Pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL226507
|
C059295
|
7 / 6 / 7 | 3 / 0 | No. 8 | No. 15 |
|
|
C00003841
|
Tetramethylscutellarein
/ 5,6,7,4'-Tetramethoxyflavone / Scutellarein 5,6,7,4'-tetramethyl ether / 5,6,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL75349
|
C072809
|
9 / 4 / 8 | No. 8 | No. 15 |
|
|
|
C00003898
|
5-Hydroxy-6,7,3',4'-tetramethoxyflavone
/ 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL226508
|
C045324
|
No. 8 | No. 15 |
|
||
|
C00033279
|
Orthosiphonone B
|
No. 160 |
|
|||||
|
C00032066
|
Neoorthosiphol A
/ (-)-Neoorthosiphol A |
CHEMBL525987
|
No. 160 |
|
||||
|
C00033272
|
Orthosiphol A
|
CHEMBL508620
|
No. 160 |
|
||||
|
C00033278
|
Orthosiphonone A
/ (-)-Orthosiphonone A |
CHEMBL447412
|
No. 160 |
|
||||
|
C00033273
|
Orthosiphol B
|
CHEMBL509129
|
No. 160 |
|
||||
|
C00032067
|
Neoorthosiphol B
/ (+)-Neoorthosiphol B |
No. 160 |
|
|||||
|
C00032696
|
Acetovanillochromene
|
No. 1756 |
|
|||||
|
C00033271
|
Orthochromene A
|
No. 2424 |
|
|||||
|
C00002437
|
Methylripariochromene A
|
No. 2424 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00003894 C00013596 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003841 C00013596 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00003841 C00013596 | 2 / 5 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00003894 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003841 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00013596 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003841 | 0 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00003894 | 4 / 4 |
| Q96GD4 | Aurora kinase B | Aur | C00003894 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00013596 | 1 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00013596 | 2 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003841 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00003841 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003841 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00013596 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00003841 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00003894 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00003841 | 1 / 1 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003894
C00013596
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00003894
C00013596
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003894
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00013596
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00003894
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003894
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #604229 | Peters anomaly |
Q16678
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (12)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|