Psoralea affinis
Species
KNApSAcK Entry
| Organism name | Psoralea affinis |
|---|---|
| Genus | Psoralea |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Psoralea |
|---|---|
| Linked NCBI taxonomy ID | 100167 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001059
|
Isovitexin
/ Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL465360
CHEMBL1601394 |
C049772
|
28 / 20 / 19 | No. 22 | No. 15 |
|
|
|
C00001055
|
Isoorientin
/ Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one |
CHEMBL239559
CHEMBL1302308 |
C057912
|
23 / 14 / 17 | 0 / 1 | No. 22 | No. 15 |
|
|
C00000297
|
Psoralen
|
CHEMBL164660
|
D005363
|
12 / 6 / 6 | 0 / 5 | No. 1282 | No. 25 |
|
|
C00002450
|
Angelicin
|
CHEMBL53569
|
C011659
|
2 / 0 / 0 | 0 / 3 | No. 1282 | No. 25 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000297 C00001055 C00001059 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001055 C00001059 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001055 C00001059 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001055 C00001059 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001055 C00001059 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001055 C00001059 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001055 C00001059 | 1 / 4 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001055 C00001059 | 1 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001055 C00001059 | 0 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001055 C00001059 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001055 C00001059 | 2 / 5 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001055 C00001059 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001055 C00001059 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001055 C00001059 | 2 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001055 C00001059 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001055 C00001059 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001055 C00001059 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000297 C00002450 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001055 C00001059 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001055 C00001059 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001055 C00001059 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001055 C00001059 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000297 C00002450 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000297 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000297 | 1 / 1 |
| P30989 | Neurotensin receptor type 1 | Neurotensin receptor | C00001059 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000297 | 3 / 3 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001055 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001059 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000297 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001059 | 7 / 3 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001059 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000297 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001059 | 1 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001059 | 2 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001059 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000297 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000297 | 0 / 1 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000297 | 1 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00001055 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000297 | 1 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (30)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (28)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002450
C00000297 |
| D056486 | Drug-Induced Liver Injury |
C00002450
C00000297 |
| D008104 | Liver Cirrhosis, Alcoholic |
C00001055
|
| D010787 | Photosensitivity Disorders |
C00002450
|
| D002280 | Carcinoma, Basal Cell |
C00000297
|
| D017484 | Dermatitis, Phototoxic |
C00000297
|
| D011565 | Psoriasis |
C00000297
|