Species

KNApSAcK Entry

Organism name Sophora fraseri
Genus Sophora
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sophora
Linked NCBI taxonomy ID 3896
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009389 External link 512 Cyclosin
/ Calycosin
/ 3'-Hydroxyformononetin
CHEMBL241608
10 / 9 / 6 No. 3 No. 15
C00009802 External link 512 2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran
/ 2',4'-Dihydroxy-5,6-methylenedioxy-2-phenylbenzofuran
CHEMBL524490
No. 27 No. 15
C00002573 External link 512 Sophoraisoflavanone A
No. 28 No. 14
C00019631 External link 512 Fraserinone A
/ 5,7,4'-Trihydroxy-2'-methoxy-5'-(1,1-dimethyl-2-propenyl)isoflavanone
No. 28 No. 14
C00009973 External link 512 Sophoronol
/ 3,5,7-Trihydroxy-2'-methoxy-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavanone
CHEMBL550446
No. 127 No. 14
C00010011 External link 512 Sophoracarpan B
/ 6-Methoxymaackiain
/ (6R,6aS,11aR)-3-Hydroxy-6-methoxy-8,9-methylenedioxypterocarpan
No. 1655

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00009389 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00009389 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00009389 4 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00009389 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00009389 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00009389 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00009389 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009389 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00009389 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009389 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#600274 Frontotemporal dementia; ftd P10636
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (6)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)