Elsholtzia nipponica
Species
KNApSAcK Entry
| Organism name | Elsholtzia nipponica |
|---|---|
| Genus | Elsholtzia |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Elsholtzia |
|---|---|
| Linked NCBI taxonomy ID | 41225 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002664
|
Phenol
|
CHEMBL14060
|
D019800
|
111 / 52 / 47 | 101 / 30 | No. 6006 |
|
Human Protein / Gene in interactions
111 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002664 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002664 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002664 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002664 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00002664 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002664 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002664 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002664 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002664 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002664 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002664 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002664 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002664 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002664 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002664 | 2 / 2 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002664 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002664 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002664 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002664 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002664 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002664 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002664 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002664 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 0 |
| P04066 | Tissue alpha-L-fucosidase | Enzyme | C00002664 | 1 / 2 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002664 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002664 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002664 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002664 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002664 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002664 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002664 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002664 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002664 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002664 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002664 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002664 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002664 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002664 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002664 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002664 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002664 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002664 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002664 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002664 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002664 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002664 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002664 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002664 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002664 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002664 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002664 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002664 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002664 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002664 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002664 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002664 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002664 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002664 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002664 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002664 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002664 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002664 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002664 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002664 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002664 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002664 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002664 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002664 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002664 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002664 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002664 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002664 | 1 / 1 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002664 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002664 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002664 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002664 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002664 | 0 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002664 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002664 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002664 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002664 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002664 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002664 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002664 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002664 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002664 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002664 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002664 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002664 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002664 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002664 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002664 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002664 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002664 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002664 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002664 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002664 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002664 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002664 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002664 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002664 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002664 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002664 | 1 / 1 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00002664 | 4 / 2 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00002664 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00002664 | 1 / 1 |
101 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 10965 | ACOT2, CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128 | acyl-CoA thioesterase 2 (EC:3.1.2.2) |
C00002664
|
| 174 | AFP, FETA, HPAFP | alpha-fetoprotein |
C00002664
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002664
|
| 249 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP | alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) |
C00002664
|
| 25805 | BAMBI, NMA | BMP and activin membrane-bound inhibitor |
C00002664
|
| 8553 | BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 | basic helix-loop-helix family, member e40 |
C00002664
|
| 10904 | BLCAP, BC10 | bladder cancer associated protein |
C00002664
|
| 813 | CALU | calumenin |
C00002664
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002664
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00002664
|
| 9469 | CHST3, C6ST, C6ST1, HSD | carbohydrate (chondroitin 6) sulfotransferase 3 (EC:2.8.2.17) |
C00002664
|
| 9076 | CLDN1, CLD1, ILVASC, SEMP1 | claudin 1 |
C00002664
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002664
|
| 1385 | CREB1, CREB | cAMP responsive element binding protein 1 |
C00002664
|
| 100160140 |
C00002664
|
||
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002664
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002664
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00002664
|
| 4051 | CYP4F3, CPF3, CYP4F, LTB4H | cytochrome P450, family 4, subfamily F, polypeptide 3 (EC:1.14.13.30) |
C00002664
|
| 26528 | DAZAP1 | DAZ associated protein 1 |
C00002664
|
| 55802 | DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF | decapping mRNA 1A |
C00002664
|
| 1654 | DDX3X, DBX, DDX14, DDX3, HLP2 | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (EC:3.6.4.13) |
C00002664
|
| 1843 | DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10 | dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) |
C00002664
|
| 22936 | ELL2 | elongation factor, RNA polymerase II, 2 |
C00002664
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002664
|
| 2114 | ETS2, ETS2IT1 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
C00002664
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002664
|
| 26190 | FBXW2, FBW2, Fwd2, Md6 | F-box and WD repeat domain containing 2 |
C00002664
|
| 8061 | FOSL1, FRA, FRA1, fra-1 | FOS-like antigen 1 |
C00002664
|
| 2623 | GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT | GATA binding protein 1 (globin transcription factor 1) |
C00002664
|
| 2624 | GATA2, DCML, MONOMAC, NFE1B | GATA binding protein 2 |
C00002664
|
| 9329 | GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA | general transcription factor IIIC, polypeptide 4, 90kDa (EC:2.3.1.48) |
C00002664
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00002664
|
| 26762 | HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 | hepatitis A virus cellular receptor 1 |
C00002664
|
| 3043 | HBB, CD113t-C, beta-globin | hemoglobin, beta |
C00002664
|
| 3280 | HES1, HES-1, HHL, HRY, bHLHb39 | hes family bHLH transcription factor 1 |
C00002664
|
| 3145 | HMBS, PBG-D, PBGD, PORC, UPS | hydroxymethylbilane synthase (EC:2.5.1.61) |
C00002664
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00002664
|
| 3188 | HNRNPH2, FTP3, HNRPH', HNRPH2, hnRNPH' | heterogeneous nuclear ribonucleoprotein H2 (H') |
C00002664
|
| 3399 | ID3, HEIR-1, bHLHb25 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
C00002664
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002664
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00002664
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002664
|
| 54556 | ING3, Eaf4, ING2, MEAF4, p47ING3 | inhibitor of growth family, member 3 |
C00002664
|
| 7071 | KLF10, EGR-alpha, EGRA, TIEG, TIEG1 | Kruppel-like factor 10 |
C00002664
|
| 1316 | KLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9 | Kruppel-like factor 6 |
C00002664
|
| 3840 | KPNA4, IPOA3, QIP1, SRP3 | karyopherin alpha 4 (importin alpha 3) |
C00002664
|
| 4041 | LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2 | low density lipoprotein receptor-related protein 5 |
C00002664
|
| 10905 | MAN1A2, MAN1B | mannosidase, alpha, class 1A, member 2 (EC:3.2.1.113) |
C00002664
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00002664
|
| 4247 | MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143) |
C00002664
|
| 4353 | MPO | myeloperoxidase (EC:1.11.2.2) |
C00002664
|
| 740 | MRPL49, C11orf4, L49mt, MRP-L49, NOF, NOF1 | mitochondrial ribosomal protein L49 |
C00002664
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00002664
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00002664
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00002664
|
| 4778 | NFE2, NF-E2, p45 | nuclear factor, erythroid 2 |
C00002664
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002664
|
| 4800 | NFYA, CBF-A, CBF-B, HAP2, NF-YA | nuclear transcription factor Y, alpha |
C00002664
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00002664
|
| 8431 | NR0B2, SHP, SHP1 | nuclear receptor subfamily 0, group B, member 2 |
C00002664
|
| 57162 | PELI1 | pellino E3 ubiquitin protein ligase 1 |
C00002664
|
| 8864 | PER2, FASPS, FASPS1 | period circadian clock 2 |
C00002664
|
| 5293 | PIK3CD, P110DELTA, PI3K, p110D | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153) |
C00002664
|
| 5292 | PIM1, PIM | pim-1 oncogene (EC:2.7.11.1) |
C00002664
|
| 9240 | PNMA1, MA1 | paraneoplastic Ma antigen 1 |
C00002664
|
| 5411 | PNN, DRS, DRSP, SDK3, memA | pinin, desmosome associated protein |
C00002664
|
| 10908 | PNPLA6, NTE, NTEMND, SPG39, iPLA2delta, sws | patatin-like phospholipase domain containing 6 (EC:3.1.1.5) |
C00002664
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002664
|
| 8493 | PPM1D, PP2C-DELTA, WIP1 | protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) |
C00002664
|
| 5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00002664
|
| 38175 |
C00002664
|
||
| 9367 | RAB9A, RAB9 | RAB9A, member RAS oncogene family |
C00002664
|
| 29803 | REPIN1, AP4, RIP60, ZNF464, Zfp464 | replication initiator 1 |
C00002664
|
| 10670 | RRAGA, FIP-1, FIP1, RAGA | Ras-related GTP binding A |
C00002664
|
| 51282 | SCAND1, RAZ1, SDP1 | SCAN domain containing 1 |
C00002664
|
| 22928 | SEPHS2, SPS2, SPS2b | selenophosphate synthetase 2 (EC:2.7.9.3) |
C00002664
|
| 150094 | SIK1, MSK, SIK, SNF1LK | salt-inducible kinase 1 (EC:2.7.11.1) |
C00002664
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00002664
|
| 9990 | SLC12A6, ACCPN, KCC3, KCC3A, KCC3B | solute carrier family 12 (potassium/chloride transporter), member 6 |
C00002664
|
| 6426 | SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a | serine/arginine-rich splicing factor 1 |
C00002664
|
| 6430 | SRSF5, HRS, SFRS5, SRP40 | serine/arginine-rich splicing factor 5 |
C00002664
|
| 51188 | SS18L2, KIAA-iso | synovial sarcoma translocation gene on chromosome 18-like 2 |
C00002664
|
| 6879 | TAF7, TAF2F, TAFII55 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa |
C00002664
|
| 23435 | TARDBP, ALS10, TDP-43 | TAR DNA binding protein |
C00002664
|
| 10732 | TCFL5, CHA, E2BP-1, Figlb, bHLHe82 | transcription factor-like 5 (basic helix-loop-helix) |
C00002664
|
| 7014 | TERF2, TRBF2, TRF2 | telomeric repeat binding factor 2 |
C00002664
|
| 7037 | TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90 | transferrin receptor |
C00002664
|
| 7050 | TGIF1, HPE4, TGIF | TGFB-induced factor homeobox 1 |
C00002664
|
| 10440 | TIMM17A, TIM17, TIM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) |
C00002664
|
| 7082 | TJP1, ZO-1 | tight junction protein 1 |
C00002664
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002664
|
| 7128 | TNFAIP3, A20, OTUD7C, TNFA1P2 | tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) |
C00002664
|
| 27242 | TNFRSF21, BM-018, CD358, DR6 | tumor necrosis factor receptor superfamily, member 21 |
C00002664
|
| 10140 | TOB1, APRO6, PIG49, TOB, TROB, TROB1 | transducer of ERBB2, 1 |
C00002664
|
| 10221 | TRIB1, C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1 | tribbles pseudokinase 1 |
C00002664
|
| 7286 | TUFT1 | tuftelin 1 |
C00002664
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00002664
|
| 7357 | UGCG, GCS, GLCT1 | UDP-glucose ceramide glucosyltransferase (EC:2.4.1.80) |
C00002664
|
| 8876 | VNN1, HDLCQ8, Tiff66 | vanin 1 (EC:3.5.1.92) |
C00002664
|
| 7444 | VRK2 | vaccinia related kinase 2 (EC:2.7.11.1) |
C00002664
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (52)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #230000 | Fucosidosis |
P04066
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
P37231 |
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (47)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00141 | Fucosidosis |
P04066
(related)
|
| H00422 | Glycoproteinoses |
P04066
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00783 | Febrile seizures |
P18507
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
30 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058186 | Acute Kidney Injury |
C00002664
|
| D001855 | Bone Marrow Diseases |
C00002664
|
| D001859 | Bone Neoplasms |
C00002664
|
| D001913 | Bowen's Disease |
C00002664
|
| D003128 | COMA |
C00002664
|
| D003556 | Cystitis |
C00002664
|
| D017449 | Dermatitis, Allergic Contact |
C00002664
|
| D003877 | Dermatitis, Contact |
C00002664
|
| D004382 | Duodenitis |
C00002664
|
| D004487 | Edema |
C00002664
|
| D005756 | Gastritis |
C00002664
|
| D006417 | Hematuria |
C00002664
|
| D006470 | Hemorrhage |
C00002664
|
| D006973 | Hypertension |
C00002664
|
| D007035 | Hypothermia |
C00002664
|
| D055623 | Keratosis, Actinic |
C00002664
|
| D048629 | Micronuclei, Chromosome-Defective |
C00002664
|
| D009784 | Occupational Diseases |
C00002664
|
| D010146 | Pain |
C00002664
|
| D020734 | Parkinsonian Disorders |
C00002664
|
| D010392 | Pemphigus |
C00002664
|
| D010523 | Peripheral Nervous System Diseases |
C00002664
|
| D010864 | Pilonidal Sinus |
C00002664
|
| D011041 | Poisoning |
C00002664
|
| D012131 | Respiratory Insufficiency |
C00002664
|
| D013088 | Spermatocele |
C00002664
|
| D006848 | Testicular Hydrocele |
C00002664
|
| D014202 | Tremor |
C00002664
|
| D014277 | Trigeminal Neuralgia |
C00002664
|
| D014860 | Warts |
C00002664
|