Species

KNApSAcK Entry

Organism name Otholobium stachyerum
Genus Otholobium
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Otholobium
Linked NCBI taxonomy ID 53909
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001055 External link 512 Isoorientin
/ Homoorientin
/ Lespecapitioside
/ Luteolin 6-C-beta-D-glucopyranoside
/ 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
CHEMBL239559
CHEMBL1302308
C057912
23 / 14 / 17 0 / 1 No. 22 No. 15
C00000297 External link 512 Psoralen
CHEMBL164660
D005363
12 / 6 / 6 0 / 5 No. 1282 No. 25
C00002450 External link 512 Angelicin
CHEMBL53569
C011659
2 / 0 / 0 0 / 3 No. 1282 No. 25

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000297 C00002450 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000297 C00001055 0 / 0
P56817 Beta-secretase 1 A1A C00000297 C00002450 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000297 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001055 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000297 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000297 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001055 1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000297 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000297 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001055 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001055 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001055 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000297 0 / 0
P06746 DNA polymerase beta Enzyme C00001055 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000297 3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001055 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001055 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000297 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000297 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001055 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001055 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001055 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001055 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00001055 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001055 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001055 1 / 1
O00255 Menin Unclassified protein C00001055 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001055 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001055 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001055 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001055 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00001055 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001055 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#114500 Colorectal cancer; crc Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (23)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002450
C00000297
D056486 Drug-Induced Liver Injury C00002450
C00000297
D008104 Liver Cirrhosis, Alcoholic C00001055
D010787 Photosensitivity Disorders C00002450
D002280 Carcinoma, Basal Cell C00000297
D017484 Dermatitis, Phototoxic C00000297
D011565 Psoriasis C00000297