Gentiana campestris

• Index
• Plant Species
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Gentiana campestris
Genus	Gentiana
Family	Gentianaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Gentianella campestris
Linked NCBI taxonomy ID	49940
Linked level	species

Family

Family in NCBI taxonomy	Gentianaceae
ID	21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002975	Swertianolin	CHEMBL468396 CHEMBL1901330		5 / 2 / 1		No. 2	No. 15
C00037010	Decussatin / 1-Hydroxy-3,7,8-trimethoxyxanthone	CHEMBL26323		1 / 1 / 1		No. 3	No. 15
C00002943	Bellidifolin / 1,5,8-Trihydroxy-3-methoxyxanthone	CHEMBL185776	C091291	9 / 4 / 4		No. 3	No. 15
C00037320	Swertianol / Isobellidifolin / 1,3,8-Trihydroxy-5-methoxyxanthone					No. 3	No. 15
C00006125	Swertisin / Flavocommelitin / 7-O-Methylapigenin 6-C-beta-D-glucopyranoside / 6-beta-D-Glucopyranosyl-4',5-dihydroxy-7-methoxyflavone / 6-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one	CHEMBL174243 CHEMBL486415				No. 22	No. 15
C00002962	Aphloiol / Mangiferin / 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone	CHEMBL1329826	C013592	27 / 17 / 17	39 / 41	No. 22	No. 15
C00010749	Eustoside					No. 1348	No. 36
C00010748	5-Deoxyeustomoside					No. 1348	No. 36
C00010746	Eustomoroside / Eustomorusside					No. 1348	No. 36
C00010747	Eustomoside					No. 1348	No. 36

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002943 C00002962 C00002975	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002943 C00002975 C00037010	1 / 1
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002943 C00002975	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002943 C00002962	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00002943 C00002975	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002943 C00002962	0 / 0
O75496	Geminin	Unclassified protein	C00002962 C00002975	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00002962	0 / 1
P39748	Flap endonuclease 1	Enzyme	C00002943	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00002943	2 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002962	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00002962	1 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00002962	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00002962	3 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002962	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002962	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002962	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002962	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002962	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002943	0 / 0
Q9Y5X4	Photoreceptor-specific nuclear receptor	NR2E3	C00002962	2 / 2
P55210	Caspase-7	C14	C00002962	0 / 0
P29466	Caspase-1	C14	C00002962	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002962	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002962	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002962	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002962	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002962	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002962	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002962	1 / 4
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002962	5 / 3
Q9Y618	Nuclear receptor corepressor 2	Unclassified protein	C00002962	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002962	0 / 0

39 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002962
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00002962
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00002962
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002962
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002962
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002962
847	CAT	catalase (EC:1.11.1.6)	C00002962
891	CCNB1, CCNB	cyclin B1	C00002962
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00002962
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00002962
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002962
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002962
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002962
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00002962
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00002962
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00002962
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00002962
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00002962
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002962
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002962
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002962
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002962
4023	LPL, HDLCQ11, LIPD	lipoprotein lipase (EC:3.1.1.34)	C00002962
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002962
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002962
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00002962
4803	NGF, Beta-NGF, HSAN5, NGFB	nerve growth factor (beta polypeptide)	C00002962
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00002962
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00002962
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002962
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002962
6716	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22)	C00002962
7015	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT	telomerase reverse transcriptase (EC:2.7.7.49)	C00002962
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002962
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002962
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002962
7364	UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9	UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17)	C00002962
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002962
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002962

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions