Aphloia madagascariensis
Species
KNApSAcK Entry
| Organism name | Aphloia madagascariensis |
|---|---|
| Genus | Aphloia |
| Family | Aphloiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aphloia |
|---|---|
| Linked NCBI taxonomy ID | 112805 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Aphloiaceae |
|---|---|
| ID | 112804 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002962
|
Aphloiol
/ Mangiferin / 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone |
CHEMBL1329826
|
C013592
|
27 / 17 / 17 | 39 / 41 | No. 22 | No. 15 |
|
Human Protein / Gene in interactions
27 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002962 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002962 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002962 | 0 / 0 |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00002962 | 2 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002962 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002962 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002962 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002962 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00002962 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00002962 | 3 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002962 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002962 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00002962 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002962 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002962 | 2 / 2 |
| P55210 | Caspase-7 | C14 | C00002962 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002962 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002962 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002962 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002962 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002962 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002962 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002962 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002962 | 1 / 4 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002962 | 5 / 3 |
| Q9Y618 | Nuclear receptor corepressor 2 | Unclassified protein | C00002962 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002962 | 0 / 0 |
39 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002962
|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002962
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002962
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002962
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002962
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002962
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00002962
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00002962
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00002962
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00002962
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00002962
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002962
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002962
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002962
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002962
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00002962
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002962
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002962
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002962
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002962
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002962
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002962
|
| 4023 | LPL, HDLCQ11, LIPD | lipoprotein lipase (EC:3.1.1.34) |
C00002962
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002962
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002962
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00002962
|
| 4803 | NGF, Beta-NGF, HSAN5, NGFB | nerve growth factor (beta polypeptide) |
C00002962
|
| 5320 | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) |
C00002962
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002962
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002962
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002962
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002962
|
| 7015 | TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT | telomerase reverse transcriptase (EC:2.7.7.49) |
C00002962
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002962
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002962
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002962
|
| 7364 | UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 | UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) |
C00002962
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002962
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002962
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #268100 | Enhanced s-cone syndrome; escs |
Q9Y5X4
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #601665 | Obesity |
P37231
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #611131 | Retinitis pigmentosa 37; rp37 |
Q9Y5X4
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
Q9Y5X4
(related)
|
| H00805 | Vitreoretinal degeneration |
Q9Y5X4
(related)
|
Diseases related to CTD interactions
41 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D016301 | Alveolar Bone Loss |
C00002962
|
| D000707 | Anaphylaxis |
C00002962
|
| D050197 | Atherosclerosis |
C00002962
|
| D001847 | Bone Diseases |
C00002962
|
| D001862 | Bone Resorption |
C00002962
|
| D003248 | Constipation |
C00002962
|
| D003457 | Cryptosporidiosis |
C00002962
|
| D003921 | Diabetes Mellitus, Experimental |
C00002962
|
| D003924 | Diabetes Mellitus, Type 2 |
C00002962
|
| D003928 | Diabetic Nephropathies |
C00002962
|
| D056486 | Drug-Induced Liver Injury |
C00002962
|
| D005234 | Fatty Liver |
C00002962
|
| D006331 | Heart Diseases |
C00002962
|
| D006561 | Herpes Simplex |
C00002962
|
| D015658 | HIV Infections |
C00002962
|
| D006946 | Hyperinsulinism |
C00002962
|
| D006949 | Hyperlipidemias |
C00002962
|
| D006967 | Hypersensitivity |
C00002962
|
| D033461 | Hyperuricemia |
C00002962
|
| D007154 | Immune System Diseases |
C00002962
|
| D007249 | Inflammation |
C00002962
|
| D007333 | Insulin Resistance |
C00002962
|
| D007511 | Ischemia |
C00002962
|
| D007674 | Kidney Diseases |
C00002962
|
| D007859 | Learning Disorders |
C00002962
|
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
C00002962
|
| D015470 | Leukemia, Myeloid, Acute |
C00002962
|
| D008175 | Lung Neoplasms |
C00002962
|
| D008569 | Memory Disorders |
C00002962
|
| D008630 | Mercury Poisoning |
C00002962
|
| D009203 | Myocardial Infarction |
C00002962
|
| D009336 | Necrosis |
C00002962
|
| D009410 | Nerve Degeneration |
C00002962
|
| D009437 | Neuralgia |
C00002962
|
| D010300 | Parkinson Disease |
C00002962
|
| D010518 | Periodontitis |
C00002962
|
| D011470 | Prostatic Hyperplasia |
C00002962
|
| D011833 | Radiation Injuries, Experimental |
C00002962
|
| D012772 | Shock, Septic |
C00002962
|
| D013276 | Stomach Ulcer |
C00002962
|
| D014235 | Trichinellosis |
C00002962
|