Species

KNApSAcK Entry

Organism name Helenium amarum
Genus Helenium
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Helenium amarum
Linked NCBI taxonomy ID 289417
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003209 External link 512 Amaralin
No. 144 No. 38
C00003218 External link 512 Aromaticin
CHEMBL494255
15 / 12 / 11 No. 495 No. 38
C00021136 External link 512 Isoheleniamarin
No. 4322
C00003372 External link 512 Tenulin
CHEMBL490324
CHEMBL1544783
C011124
6 / 1 / 7 No. 5688 No. 38
C00021185 External link 512 Heleniamarin
No. 5688 No. 38

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00003218 C00003372 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003218 C00003372 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003218 C00003372 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003218 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00003372 1 / 4
P42858 Huntingtin Unclassified protein C00003218 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003218 2 / 0
P17861 X-box-binding protein 1 Unclassified protein C00003218 1 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003218 0 / 0
P06746 DNA polymerase beta Enzyme C00003372 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003218 0 / 0
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein C00003218 1 / 5
O15118 Niemann-Pick C1 protein Unclassified protein C00003218 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003218 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003372 0 / 3
P10636 Microtubule-associated protein tau Unclassified protein C00003218 4 / 3
Q99700 Ataxin-2 Unclassified protein C00003218 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003218 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#143100 Huntington disease; hd P42858
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (17)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
Q00987 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00028 Choriocarcinoma Q00987 (related)
H00036 Osteosarcoma Q00987 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00042 Glioma Q00987 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)