Species

KNApSAcK Entry

Organism name Eriophyllum staechadifolium
Genus Eriophyllum
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Eriophyllum staechadifolium
Linked NCBI taxonomy ID 149426
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004693 External link 512 Jaceidin
/ Quercetagetin 3,3',6-trimethyl ether
/ 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone
CHEMBL161878
No. 3 No. 15
C00004635 External link 512 Isorhamnetin
/ 3'-O-Methylquercetin
/ 3,4',5,7-Tetrahydroxy-3'-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL379064
C047368
12 / 10 / 13 10 / 0 No. 3 No. 15
C00004684 External link 512 Axillarin
/ Quercetagetin 3,6-dimethyl ether
/ 3,6-Dimethoxy-5,7,3',4'-tetrahydroxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL487810
C056669
1 / 1 / 1 No. 3 No. 15
C00003278 External link 512 Eupatoriopicrin
CHEMBL221283
CHEMBL1983310
CHEMBL2000827
C032660
No. 60 No. 38
C00021827 External link 512 Presilphiperfolanol
CHEMBL1966097
No. 161 No. 38
C00020793 External link 512 Eupahakonenin B
No. 206 No. 38
C00020792 External link 512 Ligustrin
No. 306 No. 38

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004635 C00004684 1 / 1
P04745 Alpha-amylase 1 Enzyme C00004635 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004635 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004635 2 / 1
P39748 Flap endonuclease 1 Enzyme C00004635 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004635 4 / 4
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004635 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00004635 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004635 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004635 0 / 0
O00255 Menin Unclassified protein C00004635 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004635 1 / 2

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004635
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004635
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004635
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00004635
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004635
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00004635
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00004635
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00004635
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00004635
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004635

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#604229 Peters anomaly Q16678
#278300 Xanthinuria, type i P47989

KEGG DISEASE (13)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)