Inula helenium
Species
KNApSAcK Entry
| Organism name | Inula helenium |
|---|---|
| Genus | Inula |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Inula helenium |
|---|---|
| Linked NCBI taxonomy ID | 55635 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003306
|
Isohelenin
/ Isoalantolactone / Isoallantolactone |
CHEMBL273254
CHEMBL137803 CHEMBL1410671 CHEMBL1451900 CHEMBL2000732 |
C032787
|
6 / 4 / 5 | No. 69 | No. 38 |
|
|
|
C00021707
|
4-epi-Isoinuviscolide
|
CHEMBL1163771
CHEMBL1644107 |
No. 69 | No. 38 |
|
|||
|
C00021696
|
Asperilin
|
CHEMBL272445
|
No. 69 | No. 38 |
|
|||
|
C00021698
|
8-epi-Isovangustin
|
No. 69 | No. 38 |
|
||||
|
C00021705
|
Germacrene-D-lactone
|
No. 107 | No. 38 |
|
||||
|
C00021699
|
9beta-Hydroxy costunolide
|
No. 107 | No. 38 |
|
||||
|
C00021140
|
Dihydroconfertin
|
CHEMBL1165514
|
No. 144 | No. 38 |
|
|||
|
C00012881
|
1-Deoxyivangustin
/ Alloalantolactone / [3aR-(3aalpha,8abeta,9aalpha)]-3a,4,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one |
CHEMBL2332655
|
No. 178 | No. 38 |
|
|||
|
C00021706
|
1beta,10alpha-Epoxy-1,10-H-cis-inunolide
|
No. 227 | No. 38 |
|
||||
|
C00021704
|
4beta,5alpha-Epoxy-4,5-cis-inunolide
|
No. 227 | No. 38 |
|
||||
|
C00021702
|
9beta-Isovaleryloxy costunolide
|
No. 249 | No. 38 |
|
||||
|
C00021703
|
9beta-Isobutyryloxy costunolide
|
No. 249 | No. 38 |
|
||||
|
C00012893
|
Eupatal
/ Alant camphor / Inula camphor / (+)-Alantolactone / Elecampane camphor |
CHEMBL8831
CHEMBL136356 CHEMBL1592975 |
C004363
|
5 / 21 / 50 | 10 / 0 | No. 358 | No. 38 |
|
|
C00012894
|
1beta-Hydroxyalantolactone
/ [3aR-(3aalpha,5beta,8beta,8abeta,9aalpha)]-3a,5,6,7,8,8a,9,9a-Octahydro-8-hydroxy-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one |
No. 358 | No. 38 |
|
||||
|
C00012896
|
2-Oxoalantolactone
/ [3aR-(3aalpha,5beta,8abeta,9aalpha)]-3,3a,5,6,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2,7-dione |
No. 358 | No. 38 |
|
||||
|
C00003376
|
Tomentosin
/ Xanthalongin |
CHEMBL257513
CHEMBL483219 CHEMBL1164483 |
No. 857 | No. 38 |
|
|||
|
C00021710
|
8-epi-Tomentosin
|
CHEMBL257513
CHEMBL483219 CHEMBL1164483 |
No. 857 | No. 38 |
|
|||
|
C00021708
|
4alpha,5alpha-Epoxy-10alpha,14H-inuviscolide
|
CHEMBL1912051
|
No. 1203 |
|
Human Protein / Gene in interactions
9 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P03372 | Estrogen receptor | NR3A1 | C00003306 C00012893 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003306 C00012893 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00012893 | 2 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003306 | 0 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00012893 | 11 / 10 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003306 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003306 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00012893 | 7 / 37 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003306 | 1 / 1 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00012893
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00012893
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00012893
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00012893
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00012893
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00012893
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00012893
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00012893
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00012893
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00012893
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (53)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|