Species

KNApSAcK Entry

Organism name Dittrichia graveolens (L.) GREUTER
Genus Dittrichia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dittrichia
Linked NCBI taxonomy ID 56524
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029526 External link 512 4-epi-Isoinuviscolide
No. 69 No. 38
C00012947 External link 512 Graveolide
/ (+)-Graveolide
/ 2,3-Dihydroaromaticin
/ [3aR-(3aalpha,4abeta,7aalpha,8alpha,9abeta)]-Decahydro-4a,8-dimethyl-3-methyleneazuleno[6,5-b]furan-2,5-dione
CHEMBL359555
CHEMBL1911138
CHEMBL1911140
3 / 0 / 0 No. 340 No. 38
C00012852 External link 512 Ilicic acid
/ Vachanic acid
CHEMBL365824
CHEMBL408129
CHEMBL1434009
CHEMBL1562054
6 / 5 / 3 No. 398 No. 38
C00021118 External link 512 Bigelovin
CHEMBL312003
CHEMBL270297
CHEMBL486196
CHEMBL486997
C099796
22 / 17 / 18 No. 470 No. 38
C00021117 External link 512 8-epi-Helenalin
CHEMBL338474
CHEMBL354946
CHEMBL486996
CHEMBL1728820
CHEMBL1911137
37 / 36 / 29 No. 495 No. 38
C00012726 External link 512 Isocostic acid
/ (+/-)-Isocostic acid
/ cis-1,2,3,4,4a,5,6,7-Octahydro-4a,8-dimethyl-alpha-methylene-2-naphthaleneacetic acid
CHEMBL371833
No. 748
C00003376 External link 512 Tomentosin
/ Xanthalongin
CHEMBL257513
CHEMBL483219
CHEMBL1164483
No. 857 No. 38
C00012727 External link 512 Costic acid
/ Costus acid
CHEMBL486398
No. 978
C00012731 External link 512 Viscic acid
/ 3alpha-Hydroxycostic acid
/ [2R-(2alpha,4aalpha,7beta,8abeta)]-Decahydro-7-hydroxy-4a-methyl-alpha,8-bis(methylene)-2-naphthaleneacetic acid
No. 978

Human Protein / Gene in interactions

40 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00012852 C00021117 C00021118 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00012852 C00021117 C00021118 0 / 0
O75496 Geminin Unclassified protein C00021117 C00021118 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00012947 C00021117 0 / 0
P06746 DNA polymerase beta Enzyme C00012852 C00021117 0 / 0
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00012947 C00021117 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00021117 C00021118 1 / 0
P30556 Type-1 angiotensin II receptor Angiotensin receptor C00021117 C00021118 1 / 1
P11473 Vitamin D3 receptor NR1I1 C00021117 C00021118 2 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00021117 C00021118 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00021117 C00021118 0 / 0
P42858 Huntingtin Unclassified protein C00021117 C00021118 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00021117 C00021118 2 / 0
Q99700 Ataxin-2 Unclassified protein C00021117 C00021118 1 / 1
P51151 Ras-related protein Rab-9A Unclassified protein C00021117 C00021118 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00021117 C00021118 4 / 3
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor C00021117 C00021118 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00021117 C00021118 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00012947 C00021117 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00021117 C00021118 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00012852 C00021117 4 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00021117 C00021118 0 / 0
P17861 X-box-binding protein 1 Unclassified protein C00021117 C00021118 1 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00021117 C00021118 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00021117 C00021118 0 / 0
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein C00021117 C00021118 1 / 5
P11308 Transcriptional regulator ERG Unclassified protein C00012852 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00021117 0 / 0
P06280 Alpha-galactosidase A Enzyme C00021117 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00012852 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00021117 4 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00021117 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00021117 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00021117 1 / 1
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 C00021117 2 / 2
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00021117 0 / 0
P04062 Glucosylceramidase Enzyme C00021117 6 / 4
P49798 Regulator of G-protein signaling 4 Unclassified protein C00021117 2 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00021117 0 / 3
Q06710 Paired box protein Pax-8 Unclassified protein C00021118 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#612219 Ewing sarcoma; es P11308
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#143100 Huntington disease; hd P42858
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#267430 Renal tubular dysgenesis; rtd P30556
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (32)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
Q06710 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00575 Renal tubular dysgenesis P30556 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00025 Penile cancer Q00987 (related)
H00028 Choriocarcinoma Q00987 (related)
H00036 Osteosarcoma Q00987 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00042 Glioma Q00987 (related)
H00032 Thyroid cancer Q06710 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)