Coleus forskohlii
Species
KNApSAcK Entry
| Organism name | Coleus forskohlii |
|---|---|
| Genus | Coleus |
| Family | Lamiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Plectranthus barbatus |
|---|---|
| Linked NCBI taxonomy ID | 41228 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00022372
|
Coleonone
|
No. 70 |
|
|||||
|
C00022382
|
11-Oxomanoyl oxide
|
No. 70 |
|
|||||
|
C00003416
|
Coleonol
/ Forskolin |
CHEMBL52606
CHEMBL147623 CHEMBL1358402 CHEMBL1398667 CHEMBL1414148 CHEMBL1473060 CHEMBL1904897 CHEMBL1990053 |
46 / 40 / 28 | No. 531 | No. 41 |
|
||
|
C00022264
|
1,9-Dideoxyforskolin
|
CHEMBL343846
CHEMBL519570 |
C047983
|
No. 531 | No. 41 |
|
||
|
C00022265
|
Coleosol
|
No. 531 | No. 41 |
|
||||
|
C00022283
|
6beta-Hydroxy-8,13-epoxy-labd-14-en-11-one
|
No. 531 | No. 41 |
|
||||
|
C00022284
|
Coleol
/ 8,13-Epoxy-9alpha-hydroxylabd-14-en-11-one |
No. 531 | No. 41 |
|
||||
|
C00022263
|
1,9-Dideoxy-7-deacetylforskolin
|
No. 531 | No. 41 |
|
||||
|
C00022262
|
Coleonol E
|
CHEMBL343846
CHEMBL519570 |
No. 531 | No. 41 |
|
|||
|
C00022387
|
Deacetylforskolin
|
CHEMBL486619
|
C055628
|
No. 531 | No. 41 |
|
||
|
C00022389
|
Coleonol C
|
CHEMBL147617
CHEMBL1519619 |
5 / 12 / 5 | No. 531 | No. 41 |
|
||
|
C00022396
|
Coleonol F
|
No. 531 | No. 41 |
|
||||
|
C00022397
|
Coleonol D
/ Forskolin F |
No. 531 | No. 41 |
|
||||
|
C00022460
|
9-Deoxyforskolin
|
No. 531 | No. 41 |
|
||||
|
C00022461
|
6beta,7beta,9alpha-Trihydroxy-8,13-epoxy-labd-14-en-11-one
|
No. 531 | No. 41 |
|
Human Protein / Gene in interactions
49 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003416 C00022389 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003416 C00022389 | 0 / 0 |
| Q8WXD0 | Relaxin receptor 2 | Relaxin receptor | C00003416 | 1 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00003416 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003416 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00022389 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003416 | 3 / 2 |
| P11166 | Solute carrier family 2, facilitated glucose transporter member 1 | Glucose uniporter | C00003416 | 4 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00003416 | 1 / 0 |
| Q08828 | Adenylate cyclase type 1 | Enzyme | C00003416 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003416 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00003416 | 1 / 2 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00003416 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003416 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003416 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003416 | 1 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00022389 | 7 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003416 | 1 / 2 |
| P13569 | Cystic fibrosis transmembrane conductance regulator | chloride | C00003416 | 2 / 3 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00003416 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003416 | 5 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003416 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003416 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00003416 | 5 / 2 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003416 | 4 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003416 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003416 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003416 | 0 / 0 |
| Q8WUI4 | Histone deacetylase 7 | Hydrolase | C00003416 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003416 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003416 | 0 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00003416 | 1 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003416 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00003416 | 1 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00003416 | 0 / 0 |
| Q9GZV3 | High affinity choline transporter 1 | Choline Na-symporter | C00022389 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003416 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003416 | 0 / 0 |
| O60266 | Adenylate cyclase type 3 | Enzyme | C00003416 | 0 / 0 |
| O43306 | Adenylate cyclase type 6 | Enzyme | C00003416 | 0 / 0 |
| Q08462 | Adenylate cyclase type 2 | Enzyme | C00003416 | 0 / 0 |
| O60503 | Adenylate cyclase type 9 | Enzyme | C00003416 | 0 / 0 |
| P51828 | Adenylate cyclase type 7 | Enzyme | C00003416 | 0 / 0 |
| P40145 | Adenylate cyclase type 8 | Enzyme | C00003416 | 0 / 0 |
| O95622 | Adenylate cyclase type 5 | Enzyme | C00003416 | 1 / 0 |
| Q8NFM4 | Adenylate cyclase type 4 | Enzyme | C00003416 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00003416 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00003416 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00003416 | 3 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (52)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #219050 | Cryptorchidism, unilateral or bilateral |
Q8WXD0
|
| #219700 | Cystic fibrosis; cf |
P13569
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #606703 | Dyskinesia, familial, with facial myokymia; fdfm |
O95622
|
| #601042 | Dystonia 9; dyt9 |
P11166
|
| #614847 | Epilepsy, idiopathic generalized, susceptibility to, 12; eig12 |
P11166
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #606777 | Glut1 deficiency syndrome 1; glut1ds1 |
P11166
|
| #612126 | Glut1 deficiency syndrome 2; glut1ds2 |
P11166
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #158580 | Neuronopathy, distal hereditary motor, type viia; hmn7a |
Q9GZV3
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #277180 | Vas deferens, congenital bilateral aplasia of; cbavd |
P13569
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00831 | Primary dystonia |
P11166
(related)
|
| H00836 | GLUT1 deficiency syndrome (GLUT1DS) |
P11166
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00218 | Cystic fibrosis (CF) |
P13569
(related)
|
| H00933 | Hereditary pancreatitis |
P13569
(related)
|
| H01033 | Congenital bilateral absence of vas deferens |
P13569
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
Q8WXD0
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|