PCIDB

Furcraea elegans

Family in NCBI taxonomy	Asparagaceae
ID	40552

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	Liliopsida
ID	4447

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003593	Tigogenin	CHEMBL43871 CHEMBL1171146 CHEMBL1475613		3 / 5 / 1		No. 171	No. 11
C00003580	Hecogenin	CHEMBL1401685 CHEMBL1605286	C007908	8 / 16 / 14	1 / 0	No. 1222	No. 11

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003580	1 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00003593	3 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003580	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003580	11 / 10
P10828	Thyroid hormone receptor beta	NR1A2	C00003580	3 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003580	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003580	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003580	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003580	0 / 1
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00003593	5 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00003593	0 / 0

gene	gene name	gene description	KNApSAcK metabolite in interactions
54657	UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D	UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17)	C00003580

OMIM	preferred title	UniProt
#601816	Bilirubin, serum level of, quantitative trait locus 1; biliqtl1	P22309
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#218800	Crigler-najjar syndrome, type i	P22309 P22310
#606785	Crigler-najjar syndrome, type ii	P22309 P22310
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#143500	Gilbert syndrome	P22309 P22310
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#237900	Hyperbilirubinemia, transient familial neonatal; hblrtfn	P22309
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#275210	Restrictive dermopathy, lethal	P02545
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828

KEGG	name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H01205	Coumarin resistance	P11712 (related)
H00208	Hyperbilirubinemia	P22309 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)