ORTHOLOGY: K00248 Help
Entry
Symbol
ACADS, bcd
Name
butyryl-CoA dehydrogenase [EC:
1.3.8.1 ]
Pathway
map00280 Valine, leucine and isoleucine degradation
map01110 Biosynthesis of secondary metabolites
map01120 Microbial metabolism in diverse environments
Module
M00013 Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Reaction
R01175 butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
R01178 short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
R02661 2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase
R03172 (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase
R04432 propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
R04751 hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Disease
H00525 Disorders of mitochondrial fatty-acid oxidation
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
00650 Butanoate metabolism
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
09103 Lipid metabolism
00071 Fatty acid degradation
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
09106 Metabolism of other amino acids
00410 beta-Alanine metabolism
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.8 With a flavin as acceptor
1.3.8.1 short-chain acyl-CoA dehydrogenase
K00248 ACADS, bcd; butyryl-CoA dehydrogenase
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Genes
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Taxonomy UniProt
Reference
Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K
Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
Journal
J Biol Chem 260:1311-25 (1985)
Reference
Authors
Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J, Ikeda Y, Kraus J, Tanaka K
Title
Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family.
Journal
J Biol Chem 264:16321-31 (1989)
Sequence