KEGG ORTHOLOGY: K02159

ORTHOLOGY: K02159

Entry

K02159                      KO

Symbol

BAX

Name

apoptosis regulator BAX

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map01524

Platinum drug resistance

map04071

Sphingolipid signaling pathway

map04115

p53 signaling pathway

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04211

Longevity regulating pathway

map04215

Apoptosis - multiple species

map04217

Necroptosis

map04722

Neurotrophin signaling pathway

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05203

Viral carcinogenesis

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05216

Thyroid cancer

map05217

Basal cell carcinoma

map05218

Melanoma

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05417

Lipid and atherosclerosis

Disease

H00020

Colorectal cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02159  BAX; apoptosis regulator BAX
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K02159  BAX; apoptosis regulator BAX
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02159  BAX; apoptosis regulator BAX
   04215 Apoptosis - multiple species
    K02159  BAX; apoptosis regulator BAX
   04217 Necroptosis
    K02159  BAX; apoptosis regulator BAX
   04115 p53 signaling pathway
    K02159  BAX; apoptosis regulator BAX
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02159  BAX; apoptosis regulator BAX
  09149 Aging
   04211 Longevity regulating pathway
    K02159  BAX; apoptosis regulator BAX
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02159  BAX; apoptosis regulator BAX
   05202 Transcriptional misregulation in cancer
    K02159  BAX; apoptosis regulator BAX
   05203 Viral carcinogenesis
    K02159  BAX; apoptosis regulator BAX
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02159  BAX; apoptosis regulator BAX
   05212 Pancreatic cancer
    K02159  BAX; apoptosis regulator BAX
   05225 Hepatocellular carcinoma
    K02159  BAX; apoptosis regulator BAX
   05226 Gastric cancer
    K02159  BAX; apoptosis regulator BAX
   05214 Glioma
    K02159  BAX; apoptosis regulator BAX
   05216 Thyroid cancer
    K02159  BAX; apoptosis regulator BAX
   05220 Chronic myeloid leukemia
    K02159  BAX; apoptosis regulator BAX
   05217 Basal cell carcinoma
    K02159  BAX; apoptosis regulator BAX
   05218 Melanoma
    K02159  BAX; apoptosis regulator BAX
   05213 Endometrial cancer
    K02159  BAX; apoptosis regulator BAX
   05224 Breast cancer
    K02159  BAX; apoptosis regulator BAX
   05222 Small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
   05223 Non-small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05170 Human immunodeficiency virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05161 Hepatitis B
    K02159  BAX; apoptosis regulator BAX
   05160 Hepatitis C
    K02159  BAX; apoptosis regulator BAX
   05164 Influenza A
    K02159  BAX; apoptosis regulator BAX
   05162 Measles
    K02159  BAX; apoptosis regulator BAX
   05168 Herpes simplex virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05163 Human cytomegalovirus infection
    K02159  BAX; apoptosis regulator BAX
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02159  BAX; apoptosis regulator BAX
   05169 Epstein-Barr virus infection
    K02159  BAX; apoptosis regulator BAX
   05165 Human papillomavirus infection
    K02159  BAX; apoptosis regulator BAX
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K02159  BAX; apoptosis regulator BAX
   05132 Salmonella infection
    K02159  BAX; apoptosis regulator BAX
   05131 Shigellosis
    K02159  BAX; apoptosis regulator BAX
   05152 Tuberculosis
    K02159  BAX; apoptosis regulator BAX
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K02159  BAX; apoptosis regulator BAX
   05014 Amyotrophic lateral sclerosis
    K02159  BAX; apoptosis regulator BAX
   05016 Huntington disease
    K02159  BAX; apoptosis regulator BAX
   05020 Prion disease
    K02159  BAX; apoptosis regulator BAX
   05022 Pathways of neurodegeneration - multiple diseases
    K02159  BAX; apoptosis regulator BAX
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02159  BAX; apoptosis regulator BAX
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02159  BAX; apoptosis regulator BAX
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02159  BAX; apoptosis regulator BAX
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02159  BAX; apoptosis regulator BAX
   01524 Platinum drug resistance
    K02159  BAX; apoptosis regulator BAX
   01522 Endocrine resistance
    K02159  BAX; apoptosis regulator BAX
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K02159  BAX; apoptosis regulator BAX
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K02159  BAX; apoptosis regulator BAX
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K02159  BAX; apoptosis regulator BAX
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K02159  BAX; apoptosis regulator BAX

Other DBs

TC:	1.A.21.1.2

Genes

HSA:

581(BAX)

PTR:	747093(BAX)

PPS:	100991820(BAX)

GGO:	101152769(BAX)

PON:	100450682(BAX)

NLE:	100593013(BAX)

HMH:	116478225(BAX)

MCC:	718948(BAX)

MCF:	102132255(BAX)

MTHB:

126943600

MNI:	105478665(BAX)

CSAB:

103235004(BAX)

CATY:

105595265(BAX)

TGE:	112613606(BAX)

MLEU:

105539167(BAX)

RRO:	104666540(BAX)

RBB:	108523624(BAX)

TFN:	117091541(BAX)

PTEH:

111520083(BAX)

CANG:

105514789(BAX)

CJC:	100391322(BAX)

SBQ:	101050177(BAX)

CIMI:

108283911(BAX) 108287107

CSYR:

103256231(BAX)

MMUR:

105865602(BAX)

LCAT:

123623846(BAX)

PCOQ:

105809316(BAX)

OGA:	100957285(BAX)

MMU:	12028(Bax)

MCAL:

110297919(Bax)

MPAH:

110320030(Bax)

RNO:	24887(Bax)

MCOC:

116102201(Bax)

ANU:	117722249(Bax)

MUN:	110560654 110560658

CGE:	100689032(Bax)

MAUA:

101842912(Bax)

PROB:

127213848(Bax)

PLEU:

114684640(Bax)

MORG:

121449799(Bax)

MFOT:

126488161

AAMP:

119802627(Bax)

NGI:	103743639(Bax)

HGL:	101713575(Bax)

CPOC:

100730890(Bax)

CCAN:

109682703(Bax)

DORD:

105994373(Bax)

DSP:	122125840(Bax)

PLOP:

125338870(Bax)

NCAR:

124966672

OCU:

100355675

OPI:	101517703(BAX)

TUP:	102471776(BAX)

GVR:	103587762(BAX)

CFA:	403523(BAX)

CLUD:

112645177(BAX)

VVP:	112931372(BAX)

VLG:	121484229(BAX)

NPO:	129501028(BAX)

AML:	100471095(BAX)

UMR:	103657107(BAX)

UAH:	113243322(BAX)

UAR:	123776228(BAX)

ELK:

111160657

LLV:	125086017 125089829

MPUF:

101686802(BAX)

NVS:	122911843(BAX)

ORO:	101371652(BAX)

EJU:	114199627(BAX)

ZCA:	113935677(BAX)

MLX:	117998245(BAX)

NSU:	110572854(BAX)

LWW:

102729504

FCA:	493837(BAX)

PYU:	121018751(BAX)

PBG:	122494846(BAX)

LRUF:

124510927

PTG:	102949153(BAX)

PPAD:

109253092 109253093 109253096

PUC:

125915138

AJU:

106988699

HHV:	120243716(BAX)

BTA:	280730(BAX)

BOM:	102279740(BAX)

BIU:	109571778(BAX) 109571977

BBUB:

102400076(BAX)

BBIS:

104995631(BAX)

CHX:	100846984(BAX)

OAS:	443059(BAX)

BTAX:

128064207(BAX)

ODA:	120872170(BAX)

CCAD:

122421035(BAX)

SSC:	396633(BAX)

CFR:

102512073

CBAI:

105062612(BAX)

CDK:	105102890(BAX)

VPC:	102543566(BAX)

BACU:

103019528(BAX)

LVE:	103084066(BAX)

OOR:	101285349(BAX)

DLE:	111180640(BAX)

PSIU:

116744670(BAX)

NASI:

112415661(BAX)

ECB:	100054674(BAX)

EPZ:	103553312(BAX)

EAI:	106838268(BAX)

MYB:	106723573(BAX)

MYD:	102761803(BAX)

MMYO:

118655437(BAX)

MLF:	102417074(BAX)

MNA:	107531901(BAX)

PKL:	118712174(BAX)

HAI:	109391068(BAX)

DRO:	112310132(BAX)

AJM:	119037607(BAX)

PDIC:

114510992(BAX)

PHAS:

123830279(BAX)

MMF:	118638701(BAX)

RFQ:	117034548(BAX)

PALE:

102885135(BAX)

PGIG:

120606950(BAX)

PVP:	105301762(BAX)

RAY:	107498831(BAX)

MJV:	108400315(BAX)

TOD:	119248671 119248674 119249544 119249545 119249546 119249548 119249549 119249551 119249552 119249553 119249555 119249569

SARA:

101540951(BAX)

LAV:	100673560(BAX)

TMU:

101356564

ETF:	101646711(BAX)

DNM:	101432154(BAX)

MDO:	100030412(BAX)

GAS:	123242888(BAX)

AFZ:

127556582

PCW:	110219776(BAX)

OAA:	114814649(BAX)

LSR:	110481417(BAX)

PMOA:

120510409(BAX)

PRUF:

121364459

PHI:	102106020(BAX)

PMAJ:

107199046(BAX)

CCAE:

111943854(BAX)

SVG:	106864241(BAX)

FPG:	101920283(BAX)

TALA:

116963154

SHAB:

115602910(BAX)

ASN:	102384471(BAX)

AMJ:	102568113(BAX) 106737548

CPOO:

109320825(BAX) 109320834

PSS:

102446385

CMY:	102942796(BAX)

CPIC:

101948093(BAX)

TST:	117889126 117889156

MRV:	120388365 120388370

ACS:	100561911 100562834(bax)

PVT:	110078506 110078547

SUND:

121934264 121934534

PBI:	103058396 103067636

PMUR:

107282460 107282547 107295492

CTIG:

120304538 120304539

TSR:	106538695 106541284

PGUT:

117669122 117669123

PTEX:

113443551(BAX) 113443578

NSS:	113418550(BAX) 113418615

VKO:	123032047 123032277

PMUA:

114581596(BAX)

ZVI:	118095300(BAX)

HCG:	128329391 128331435

GJA:	107116597 107116610

STOW:

125445143(BAX)

XLA:	108696744(bax.L) 373637(bax.S)

XTR:	394793(bax)

NPR:	108796054(BAX)

RTEM:

120916527(BAX)

BBUF:

121002334(BAX)

BGAR:

122926696(BAX)

DRE:	100004321 58081(baxa) 767645(zgc:153993)

SRX:	107720019 107721480 107727097 107729426 107729452 107729453 107730087 107730726 107730775

SANH:

107654525 107658414 107658416 107658432 107674732 107679719 107686821 107693506

SGH:	107548291 107548334 107583031 107590365 107594474 107601305

CCAR:

109047252 109054919 109054953 109058994 109061123 109063226 109070275 109077429

CAUA:

113045944 113045952 113047019 113047208 113047209 113051791 113097183(bax) 113106509

CGIB:

127951570 127952265 127962465 128016539

PTET:

122338089(baxa) 122349394(zgc:153993)

LROH:

127162684(baxa) 127168874(zgc:153993)

PPRM:

120489578(baxb) 120489703(baxa) 120492712(zgc:153993)

MAMB:

125265753(zgc:153993) 125272083(baxa) 125277032(baxb)

CIDE:

127509026 127516808(zgc:153993)

MASI:

127412091 127445006(zgc:153993) 127450822 127451841

IPU:	100528667(baxa) 108259599(baxb) 108270970(zgc:153993) 108274750 128629193 128629195 128629196 128629197

PHYP:

113527905(bax) 113527907 113528497 113536591

SMEO:

124390954(zgc:153993) 124397010 124397372

TFD:	113646760(zgc:153993) 113652242(baxa)

AMEX:

103023787(bax) 103025681 103042396 103047816

CMAO:

118819120(zgc:153993) 118821229(baxa)

EEE:	113578802 113580268 113589910(bax)

TRU:	101067511 101068139(bax) 101069964

TNG:	GSTEN00021995G001

LCO:	104923927 104927165 104933823

NCC:

104944891

CGOB:

115006370 115012305(bax)

ELY:	117256719(zgc:153993) 117260756 117267804 117268476

EFO:	125878877 125879173 125900999 125901010(zgc:153993)

PLEP:

121943319(zgc:153993) 121943733 121956673 121956769

SLUC:

116059287 116062819 116067388(zgc:153993)

ECRA:

117942138(zgc:153993) 117957911 117958554

ESP:	116675297 116683326 116686021 116703270(bax) 116703331

PFLV:

114560203 114569518(bax) 114569810

GAT:	120810188(zgc:153993) 120827139 120828108

PPUG:

119198089(zgc:153993) 119220118 119220309

MSAM:

119890589(zgc:153993) 119892082(baxa)

SCHU:

122868367 122876431(zgc:153993)

CUD:	121509517(zgc:153993) 121529111

ALAT:

119013666 119014265 119017934(zgc:153993)

MZE:	101468197(bax) 101475737 101484052 112432380

ONL:	100706164 106097998 109201890

OAU:	116312494 116323706(zgc:153993) 116335600

OLA:	101168213 101168687

OML:	112145947 112158138

XMA:	102229835 102238210 106700271

XCO:	114143133 114160279 114160286

XHE:	116719101 116735411(bax)

PRET:

103461094 103462295 103468662 103468663

PFOR:

103142241 103142242 103150954

PLAI:

106953891 106960487 106962490

PMEI:

106910517 106925142 106925143

GAF:	122819457(zgc:153993) 122821472 122821473

CVG:	107081311 107084722

CTUL:

119777841(zgc:153993) 119778850 119778851

GMU:	124862417 124863494 124863939 124864490 124867579(zgc:153993)

NFU:	107372818 107372970 107378479(bax) 107378480

KMR:	108237852(zgc:153993) 108246126 108246134

ALIM:

106526563 106528358 106528364

NWH:	119421919 119430209(zgc:153993)

AOCE:

111562459 111576238 111581681(bax)

MCEP:

124997474 125005918(zgc:153993) 125021757

CSEM:

103392613 103393523

POV:	109625138 109631661 109634241(bax)

SSEN:

122776547(zgc:153993) 122785134 122785171 122785876

HHIP:

117759448(zgc:153993) 117766953

HSP:	118111531(zgc:153993) 118123058

LCF:	108874378 108880508(zgc:153993) 108898556 108900795

SDU:	111217465(bax) 111221747 111236249

SLAL:

111660532(bax) 111669314

XGL:	120788025 120788415 120795111(zgc:153993)

HCQ:	109508060 109508612 109519324(bax)

SSCV:

125966926(zgc:153993) 125983773

BPEC:

110160566 110164773 110167787(bax) 110174516

MALB:

109964251(bax) 109967870 109973692

BSPL:

114852574(zgc:153993) 114860604

SASA:

106561972(BAX) 106583949 106587134(BAX) 106600761 106601126 106607327 106607328

STRU:

115167497 115170832 115171149 115192161 115198352 115198360 115202897

OTW:	112225734 112226023 112246045 112249035 112251217 112258413 112263519

OMY:	110486294 110506337 110521871 110526223 110537938 110538228

OGO:	123999552(baxb) 123999637 124015248 124015249 124033167 124035098 124037970

ONE:	115104160 115104161 115110050 115110306 115112092 115113507 115145272

SALP:

111969233 111971873 111975063 111980445 111980805 111981208 112078424

SNH:	120025191(zgc:153993) 120032808(baxb) 120034478 120034479 120036277 120045962 120052702

CCLU:

121550603 121557689 121569550 121570167 121573325 123482539

ELS:	105013211(bax) 105017307 105031446 105031447

SFM:	108923902 108941669(bax)

PKI:	111836833(bax) 111836931 111851814

AANG:

118214689(zgc:153993) 118217377(baxa) 118221131

LOC:	102689963(bax)

PSPA:

121294441 121329741

ARUT:

117432031(zgc:153993) 117434851

PSEX:

120525983(zgc:153993) 120542240(baxb)

LCM:	102352490(BAX) 102359041

CMK:	103175017(zgc:153993) 103190153 103190154

RTP:

109918844

CPLA:

122542066 122557611(zgc:153993)

CIN:

SCLV:

SPU:

APLC:

SKO:

ATD:

AGB:

DCI:

FOC:

CSEC:

DMK:

EAF:

LSM:

PPOI:

DSV:

VDE:

VJA:

TUT:	107368503 107369599 107369909 107370717

DFR:

124493341

SDM:	118199843 118204797

LPOL:

106468504

LGI:	LOTGIDRAFT_68260

PCAN:

112554373 112559719

BGT:	106068564 106070231 106071264 106079683

GAE:	121380597 121386736

HRF:	124131502 124135449

HRJ:	124264529 124264530

CRG:

MYI:

PMAX:

MMER:

DPOL:

OBI:

OSN:	115217176 115220558

LAK:	106154378 106168833

SMM:	Smp_072180

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114529280 114529417 114531458

XEN:	124450326 124457735

HMG:	100199542 100202650 100203138 100203439

TAD:	TRIADDRAFT_63759 TRIADDRAFT_7511

AQU:

100631893

» show all

Reference

PMID:8358790

Authors

Oltvai ZN, Milliman CL, Korsmeyer SJ

Title

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

Journal

Cell 74:609-19 (1993)
DOI:10.1016/0092-8674(93)90509-O

Sequence

[hsa:581]

Reference

PMID:15776018

Authors

Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ

Title

Proapoptotic BAX and BAK control multiple initiator caspases.

Journal

EMBO Rep 6:379-85 (2005)
DOI:10.1038/sj.embor.7400375

Reference

PMID:18948948

Authors

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD

Title

BAX activation is initiated at a novel interaction site.

Journal

Nature 455:1076-81 (2008)
DOI:10.1038/nature07396

Sequence

[hsa:581]

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Ontology (4)   
   KEGG BRITE (3)   
   TC (1)   
Pathway (100)   
   KEGG PATHWAY (100)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (713)   
   KEGG GENES (612)   
   KEGG MGENES (12)   
   RefGene (84)   
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Literature (3)   
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