KEGG ORTHOLOGY: K03512

ORTHOLOGY: K03512

Entry

K03512                      KO

Symbol

POLL

Name

DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]

Pathway

map03410

Base excision repair

map03450

Non-homologous end-joining

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    K03512  POLL; DNA polymerase lambda
   03450 Non-homologous end-joining
    K03512  POLL; DNA polymerase lambda
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K03512  POLL; DNA polymerase lambda
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     K03512  POLL; DNA polymerase lambda
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     K03512  POLL; DNA polymerase lambda
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     K03512  POLL; DNA polymerase lambda
DNA polymerases [br01612.html]
DNA polymerases in prokaryotes, eukaryotes and viruses
  K03512

Other DBs

GO:

0003887

Genes

HSA:	27343(POLL)

PTR:	450687(POLL)

PPS:	100978076(POLL)

GGO:	101152688(POLL)

PON:	100458210(POLL)

PPYG:

129044898(POLL)

NLE:	100583874(POLL)

HMH:	116484740(POLL)

SSYN:

129467243(POLL)

MCC:	711924(POLL)

MCF:	101867295(POLL)

MTHB:

126963071

MNI:	105478368(POLL)

CSAB:

103216413(POLL)

CATY:

105581862(POLL)

PANU:

100846950(POLL)

TGE:	112631288(POLL)

MLEU:

105537766(POLL)

RRO:	104656497(POLL)

RBB:	108515127(POLL)

TFN:	117067928(POLL)

PTEH:

111538824(POLL)

CANG:

105507123(POLL)

CJC:	100390308(POLL)

SBQ:	101033540(POLL)

CIMI:

108306332(POLL)

ANAN:

105708200(POLL)

CSYR:

103252770(POLL)

MMUR:

105873944(POLL)

LCAT:

123650105(POLL)

PCOQ:

105824330(POLL)

OGA:	100942496(POLL)

MMU:	56626(Poll)

MCAL:

110285482(Poll)

MPAH:

110326947(Poll)

RNO:	361767(Poll)

MCOC:

116103922(Poll)

ANU:	117704082(Poll)

MUN:	110556236(Poll)

CGE:	100751096(Poll)

MAUA:

101832059(Poll)

PROB:

127233257(Poll)

PLEU:

114708142(Poll)

MORG:

121453805(Poll)

MFOT:

126503244

AAMP:

119805225(Poll)

NGI:	103744002(Poll)

HGL:	101696600(Poll)

CPOC:

100729389(Poll)

CCAN:

109691320(Poll)

DORD:

105986560(Poll)

DSP:	122115896(Poll)

PLOP:

125346140(Poll)

NCAR:

124985148

MMMA:

107149818(Poll)

OCU:

100351030

OPI:	101526219(POLL)

TUP:	102485584(POLL)

GVR:	103598083(POLL)

CFA:	608341(POLL)

CLUD:

112672222(POLL)

VVP:	112915159(POLL)

VLG:	121485697(POLL)

NPO:	129523367(POLL)

AML:	100471165(POLL)

UMR:	103658987(POLL)

UAH:	113251852(POLL)

UAR:	123795889(POLL)

ELK:

111145283

LLV:

125085073

MPUF:

101690817(POLL)

MNP:	132016716(POLL)

MLK:	131828519(POLL)

NVS:	122901036(POLL)

ORO:	101372287(POLL)

EJU:	114205414(POLL)

ZCA:	113920958(POLL)

MLX:	118025220(POLL)

NSU:	110589634(POLL)

FCA:	101084138(POLL)

PYU:	121037139(POLL)

PCOO:

112854456(POLL)

PBG:	122493161(POLL)

PVIV:

125148219(POLL)

LRUF:

124507075

PTG:	102954816(POLL)

PPAD:

109272796(POLL)

PUC:

125932889

AJU:

106966879

HHV:	120243201(POLL)

BTA:	522307(POLL)

BOM:	102280445(POLL)

BIU:	109552987(POLL)

BBUB:

102400301(POLL)

BBIS:

105002693(POLL)

CHX:	100861350(POLL)

OAS:	101102947(POLL)

BTAX:

128067671(POLL)

ODA:	120873544(POLL)

CCAD:

122446006(POLL)

MBEZ:

129555423(POLL)

SSC:	100153781(POLL)

CFR:	102509908(POLL)

CBAI:

105081723(POLL)

CDK:	105084339(POLL)

VPC:	102528120(POLL)

BACU:

103002412(POLL)

BMUS:

118882531(POLL)

LVE:	103068329(POLL)

OOR:	101287047(POLL)

DLE:	111172374(POLL)

PCAD:

102975367(POLL)

PSIU:

116741723(POLL)

NASI:

112393061(POLL)

ECB:	100070125(POLL)

EPZ:	103551397(POLL)

EAI:	106828853(POLL)

MYB:	102249173(POLL)

MYD:	102751765(POLL)

MMYO:

118669826(POLL)

MLF:	102428615(POLL)

MDT:	132214256(POLL)

PKL:	118718904(POLL)

EFUS:

103288494(POLL)

MNA:	107542640(POLL)

DRO:	112300375(POLL)

SHON:

118999494(POLL)

AJM:	119059693(POLL)

PDIC:

114497927(POLL)

PHAS:

123829094(POLL)

MMF:	118632149(POLL)

PPAM:

129077130(POLL)

HAI:	109379628(POLL)

RFQ:	117035912(POLL)

PALE:

102894809(POLL)

PGIG:

120609172(POLL)

PVP:	105304645(POLL)

RAY:	107497799(POLL)

MJV:	108405918(POLL)

TOD:	119233545(POLL)

SARA:

101540935(POLL)

SETR:

126033838(POLL)

LAV:	100661337(POLL)

TMU:

101346358

ETF:	101660853(POLL)

DNM:	101438287(POLL)

MDO:	100023482(POLL)

GAS:	123236240(POLL)

SHR:	100929690(POLL)

AFZ:

127551498

PCW:	110194590(POLL)

TVP:	118829149(POLL)

OAA:	100080532(POLL)

GGA:	423853(POLL)

PCOC:

116231694(POLL)

MGP:	100545174(POLL)

CJO:	107316010(POLL)

TPAI:

128077476(POLL)

LMUT:

125693206(POLL)

NMEL:

110399277(POLL)

APLA:

101796177(POLL)

ACYG:

106035621(POLL)

CATA:

118248590(POLL)

AFUL:

116491138(POLL)

TGU:	100226666(POLL)

LSR:	110473588(POLL)

SCAN:

103813870(POLL)

PMOA:

120502027(POLL)

OTC:	121341836(POLL)

PRUF:

121350150(POLL)

GFR:	102040081(POLL)

FAB:	101812248(POLL)

OMA:	130254765(POLL)

PHI:	102101584(POLL)

PMAJ:

107206778(POLL)

CCAE:

111931253(POLL)

CCW:	104695735(POLL)

CBRC:

103624549(POLL)

ETL:	114070479(POLL)

ZAB:	102074270(POLL)

ZLE:	135449773(POLL)

ACHL:

103807530(POLL)

SVG:	106857618(POLL)

MMEA:

130581830(POLL)

HRT:	120756011(POLL)

SATI:

136364085(POLL)

FPG:	101923241(POLL)

FCH:	102050496(POLL)

CCRI:

104160650(POLL)

NNT:	104400652(POLL)

SHAB:

115608034(POLL)

ACUN:

113481523(POLL)

TALA:

104363027(POLL)

ACHC:

115348203(POLL)

HALD:

104319721(POLL)

HLE:	104830117(POLL)

AGEN:

126042595

GCL:

127017648

CSTI:

104551922(POLL)

LDI:	104342850(POLL)

MNB:	103770406(POLL)

DPUB:

104307088(POLL)

AVIT:

104279890(POLL)

BRHI:

104488460(POLL)

EGZ:	104125636(POLL)

NNI:	104012624(POLL)

PCRI:

104025787(POLL)

PCAO:

104040347(POLL)

PADL:

103916273(POLL)

AFOR:

103897695(POLL)

FGA:	104081546(POLL)

GSTE:

104252738(POLL)

CLV:	102083800(POLL)

MUI:	104547401(POLL)

PGUU:

104472236(POLL)

PLET:

104617929(POLL)

EHS:	104511459(POLL)

CMAC:

104487546(POLL)

CUCA:

104059755(POLL)

TEO:	104373954(POLL)

BREG:

104634601(POLL)

OHA:	104337991(POLL)

ACAR:

104529383(POLL)

CPEA:

104390873(POLL)

CVF:	104294619(POLL)

RTD:	128911367(POLL)

AAM:

106484671

AROW:

112967885(POLL)

NPD:	112957079(POLL)

TGT:	104578760(POLL)

DNE:	112984808(POLL)

SCAM:

104138119(POLL)

ASN:	102381613(POLL)

AMJ:	102568731(POLL)

CPOO:

109324263(POLL)

GGN:	109287548(POLL)

PSS:	102451534(POLL)

CMY:	102947270(POLL)

CCAY:

125639686(POLL)

DCC:	119858178(POLL)

CPIC:

101935622(POLL)

TST:	117879886(POLL)

CABI:

116833944(POLL)

MRV:	120409339(POLL)

ACS:	100558291(poll)

ASAO:

132770881(POLL)

PVT:	110077591(POLL)

SUND:

121926508(POLL)

PBI:	103062692(POLL)

PMUR:

107285274(POLL)

CTIG:

120302576(POLL)

TSR:	106549200(POLL)

PGUT:

117678624(POLL)

APRI:

131201453(POLL)

PTEX:

113436663(POLL)

NSS:	113413733(POLL)

VKO:	123026924(POLL)

PMUA:

114597558(POLL)

PRAF:

128414317(POLL)

ZVI:	118094085(POLL)

HCG:	128351544(POLL)

GJA:	107114449(POLL)

STOW:

125438291(POLL)

EMC:	129332798(POLL)

XLA:	108696155(poll.L)

XTR:	100101731(poll)

NPR:	108794058(POLL)

RTEM:

120947015(POLL)

BBUF:

121003847(POLL)

BGAR:

122919916(POLL)

MUO:

115459069

GSH:	117358719(POLL)

DRE:	406697(poll)

SRX:

107708667

SANH:

107704325

SGH:

107602756

CAUA:

113044411(poll)

CGIB:

127949609

PTET:

122352519(poll)

LROH:

127171838(poll)

OMC:	131539801(poll)

PPRM:

120468872(poll)

RKG:	130087861(poll)

MAMB:

125272364(poll)

CIDE:

127516197

CERY:

137032302(poll)

MASI:

127443817

TROS:

130552610(poll)

TDW:	130438717(poll)

MANU:

129444350(poll)

IPU:

108259057

IFU:	128602006(poll)

PHYP:

113537583(poll)

SMEO:

124378501(poll)

TFD:	113663836(poll)

TVC:	132839696(poll)

TRN:	134328611(poll)

AMEX:

103047297(poll)

CMAO:

118801961(poll)

EEE:	113577002(poll)

CHAR:

105891046(poll)

TRU:	101065601(poll)

TFS:	130526947(poll)

TNG:	GSTEN00022704G001

LCO:	104921617(poll)

NCC:	104946031(poll)

TBEN:

117474468 117474778

CGOB:

115010487(poll)

PGEO:

117453465(poll)

GACU:

117561600(poll)

EMAC:

134865318(poll)

ELY:	117254558(poll)

EFO:	125885412(poll)

PLEP:

121942152(poll)

SLUC:

116043056(poll)

ECRA:

117937508(poll)

ESP:	116696826(poll)

PFLV:

114569009(poll)

GAT:	120825169(poll)

PPUG:

119217539(poll)

AFB:	129096006(poll)

CLUM:

117736563(poll)

PSWI:

130190070(poll)

MSAM:

119892815 119899575(poll)

SCHU:

122873654(poll)

CUD:	121507994(poll)

ALAT:

119028691(poll)

MZE:	101473944(poll)

ONL:	100699150(poll)

OAU:	116331075(poll)

OLA:	101161125(poll)

OML:	112137283(poll)

CSAI:

133452913(poll)

XMA:	102228851(poll)

XCO:	114144861(poll)

XHE:	116720179(poll)

PRET:

103465121(poll)

PFOR:

103131407(poll)

PLAI:

106939721(poll)

PMEI:

106933733(poll)

GAF:	122829548(poll)

PPRL:

129366865(poll)

CVG:	107090744(poll)

CTUL:

119783317(poll)

GMU:	124863075 124863792

NFU:	107395362(poll)

KMR:	108236311(poll)

ALIM:

106518789(poll)

NWH:	119422845(poll)

AOCE:

111566306(poll)

MCEP:

125003634(polL)

POV:	109627542(poll)

SSEN:

122771543(poll)

HHIP:

117770635(poll)

HSP:	118122812(poll)

PPLT:

128437148(poll)

SMAU:

118312412(poll)

LCF:

108875602

SDU:	111229383(poll)

SLAL:

111663385 111666620(poll)

XGL:	120800637(poll)

HCQ:	109527313(poll)

SSCV:

125968896

SBIA:

133506128(poll)

PEE:	133404037(poll)

PTAO:

133476429(poll)

BPEC:

110175710(poll)

MALB:

109957981(poll)

BSPL:

114852351(poll)

SJO:	128371209(poll)

SASA:

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:	109887484(poll)

OKE:

118389332

SALP:

112073878

SNH:

120027787

CCLU:

121532623(poll)

ELS:	105012237(poll)

SFM:	108933662(poll)

PKI:	111836988(poll)

AANG:

118220581(poll)

LOC:	102682906(poll)

PSPA:

121321627

ARUT:

117416065

PSEX:

120514436(poll)

LCM:	102345867(POLL)

CMK:	103190566(poll)

RTP:	109923288(poll)

CPLA:

122561277(poll)

HOC:	132826340(poll)

LERI:

129704174(poll)

PMRN:

116941394(POLL)

LRJ:	133345461(POLL)

BFO:

BBEL:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

HVI:

MQU:

PHU:	Phum_PHUM359150

FOC:

TPAL:

CSEC:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

TCF:

DSV:

RSAN:

RMP:	119176604 119182102

CSCU:

CVS:

SDM:

LPOL:

PMEO:

TSP:

HRO:	HELRODRAFT_161346

LGI:	LOTGIDRAFT_72491

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:	107331921 107331924

AMIL:

PDAM:

SPIS:

DGT:

XEN:

RES:

TAD:	TRIADDRAFT_28268

AQU:

100640740

ATH:	AT1G10520(Pol{lambda})

ALY:	9325878 9328770

CRB:

17898374

CSAT:

104739664 104755267 104768943

EUS:	EUTSA_v10009477mg

BRP:

BNA:

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10031184mg

PVY:

MINC:

TCC:

GRA:

GHI:	107901984 107948535

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_004G0710000

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:	11418046 25498091

TPRA:

123906784

CAM:

101499677

PSAT:

127119404

VVO:	131646259 131651241 131651256

LJA:

130739951

ADU:

107488909

AIP:

107643500

AHF:	112750080 112801052

LANG:

109330533

PCIN:

129323210

QSA:	O6P43_025346

FVE:	101307784 101308082

RCN:	112199835 112200406

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8270388 8280791

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	119999850 120001034

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107793193 107817483

NSY:

NTO:

NAU:

INI:

ITR:	116004188 116027911

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110713045 110713687

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:	4340604(OsPolL)

OBR:

OGL:

BDI:

ATS:

TDC:	119327557 119342063

TAES:

123148969 123156776 123164745

TUA:

125518710

LPER:

127317506

LRD:	124674529 124708371

SBI:

8057897

ZMA:

100383279

MFLO:

136521208 136528674 136528837

SITA:

SVS:

PVIR:

PHAI:

EGU:

MUS:

ZOF:	121969904 121975009

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_106459 SELMODRAFT_155063 SELMODRAFT_83116 SELMODRAFT_86291

PPP:

112292860

MNG:

MNEG_0586

CSL:	COCSUDRAFT_60646

CVR:	CHLNCDRAFT_138090 CHLNCDRAFT_138091

APRO:

F751_2729

OTA:	OT_ostta09g04280

BPG:	Bathy10g00110

MIS:	MICPUN_59282

MPP:	MICPUCDRAFT_45770

CME:	CYME_CMQ426C

CCP:	CHC_T00005704001

BNN:	FOA43_000660

BBRX:

BRETT_003279

OPA:	HPODL_00479

CNE:

CNI01570

CNB:

CNBH1480

CNG:	CNAG_07766

CGI:	CGB_H2300W

CDEU:

CNBG_2658

KMG:	30165807(I203_103286)

KNE:	92181329(IAR55_004071)

TMS:	TREMEDRAFT_26921

TASA:

A1Q1_07852

CCAC:

CcaHIS019_0511040(CcaverHIS019_0511040)

TVS:	TRAVEDRAFT_59518

SHS:	STEHIDRAFT_68704

ADL:	AURDEDRAFT_83573

FME:	FOMMEDRAFT_105006

LBC:	LACBIDRAFT_319108

CCI:	CC1G_01597

ABP:	AGABI1DRAFT122771(AGABI1DRAFT_122771)

ABV:	AGABI2DRAFT227537(AGABI2DRAFT_227537)

MRR:	Moror_16092

E1B28_013753

CPUT:

CONPUDRAFT_63239

SLA:	SERLADRAFT_452929

UMA:	UMAG_00599

RIE:	OCT59_008108

MBR:	MONBRDRAFT_39216 MONBRDRAFT_7518

SRE:	PTSG_10190

DFA:

DFA_08207

TET:	TTHERM_00732550

PTM:	GSPATT00008489001 GSPATT00012937001 GSPATT00015723001 GSPATT00027758001

NGD:	NGA_0387800(POLL)

PIF:	PITG_03516

PSOJ:

PHYSODRAFT_309246

SPAR:

SPRG_07053

EHX:	EMIHUDRAFT_214242 EMIHUDRAFT_237588

GTT:	GUITHDRAFT_52423

NGR:	NAEGRDRAFT_62711

» show all

Reference

PMID:11457865

Authors

Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L

Title

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair.

Journal

J Biol Chem 276:34659-63 (2001)
DOI:10.1074/jbc.M106336200

Sequence

[hsa:27343]

Reference

PMID:15537631

Authors

Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hubscher U

Title

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.

Journal

J Biol Chem 280:1971-81 (2005)
DOI:10.1074/jbc.M411650200

Sequence

[hsa:27343]

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Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2050)   
   KEGG GENES (699)   
   KEGG MGENES (337)   
   RefGene (999)   
   OC (15)   
Literature (2)   
   PubMed (2)   
All databases (2062)   

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