KEGG   ORTHOLOGY: K04728
Entry
K04728                      KO                                     
Symbol
ATM, TEL1
Name
serine-protein kinase ATM [EC:2.7.11.1]
Pathway
map01524  Platinum drug resistance
map03440  Homologous recombination
map04064  NF-kappa B signaling pathway
map04068  FoxO signaling pathway
map04110  Cell cycle
map04115  p53 signaling pathway
map04210  Apoptosis
map04214  Apoptosis - fly
map04218  Cellular senescence
map05131  Shigellosis
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05170  Human immunodeficiency virus 1 infection
map05202  Transcriptional misregulation in cancer
map05206  MicroRNAs in cancer
Disease
H00005  Chronic lymphocytic leukemia
H00064  Ataxia telangiectasia
H00094  Immunodeficiency associated with DNA repair defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K04728  ATM, TEL1; serine-protein kinase ATM
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04728  ATM, TEL1; serine-protein kinase ATM
   04068 FoxO signaling pathway
    K04728  ATM, TEL1; serine-protein kinase ATM
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04728  ATM, TEL1; serine-protein kinase ATM
   04210 Apoptosis
    K04728  ATM, TEL1; serine-protein kinase ATM
   04214 Apoptosis - fly
    K04728  ATM, TEL1; serine-protein kinase ATM
   04115 p53 signaling pathway
    K04728  ATM, TEL1; serine-protein kinase ATM
   04218 Cellular senescence
    K04728  ATM, TEL1; serine-protein kinase ATM
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K04728  ATM, TEL1; serine-protein kinase ATM
   05206 MicroRNAs in cancer
    K04728  ATM, TEL1; serine-protein kinase ATM
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04728  ATM, TEL1; serine-protein kinase ATM
   05170 Human immunodeficiency virus 1 infection
    K04728  ATM, TEL1; serine-protein kinase ATM
   05165 Human papillomavirus infection
    K04728  ATM, TEL1; serine-protein kinase ATM
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04728  ATM, TEL1; serine-protein kinase ATM
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04728  ATM, TEL1; serine-protein kinase ATM
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04728  ATM, TEL1; serine-protein kinase ATM
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K04728  ATM, TEL1; serine-protein kinase ATM
   03400 DNA repair and recombination proteins
    K04728  ATM, TEL1; serine-protein kinase ATM
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04728  ATM, TEL1; serine-protein kinase ATM
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K04728  ATM, TEL1; serine-protein kinase ATM
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    K04728  ATM, TEL1; serine-protein kinase ATM
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K04728  ATM, TEL1; serine-protein kinase ATM
Genes
HSA: 472(ATM)
PTR: 451530(ATM)
PPS: 100982830(ATM)
GGO: 101123696(ATM)
PON: 100451505(ATM)
MCC: 100427400(ATM)
MCF: 102137525(ATM)
CSAB: 103248401(ATM)
CATY: 105588729(ATM)
PANU: 101021695(ATM)
TGE: 112606480(ATM)
RRO: 104660482(ATM)
RBB: 108517380(ATM)
TFN: 117081112(ATM)
PTEH: 111540104(ATM)
CJC: 100402387(ATM)
SBQ: 101040534(ATM)
CSYR: 103257608(ATM)
MMUR: 105876116(ATM)
OGA: 100947578(ATM)
MMU: 11920(Atm)
MCAL: 110301441(Atm)
MPAH: 110327456(Atm)
RNO: 300711(Atm)
MCOC: 116073222(Atm)
MUN: 110549468(Atm)
CGE: 100754226
PLEU: 114690277(Atm)
NGI: 103731335(Atm)
HGL: 101718948(Atm)
CPOC: 100717983(Atm)
DORD: 105980824(Atm)
DSP: 122110260(Atm)
NCAR: 124958109
OCU: 100349299(ATM)
OPI: 101532614(ATM)
TUP: 102502093(ATM)
CFA: 479450(ATM)
VVP: 112925961(ATM)
VLG: 121500044(ATM)
AML: 100480638(ATM)
UMR: 103662421(ATM)
UAH: 113260096(ATM)
UAR: 123792533(ATM)
ELK: 111153730
LLV: 125078433
MPUF: 101673428(ATM)
ORO: 101378264(ATM)
EJU: 114211448(ATM)
ZCA: 113913870(ATM)
MLX: 118013186(ATM)
FCA: 101089291(ATM)
PYU: 121035348(ATM)
PBG: 122482919(ATM)
PTG: 102958898(ATM)
PPAD: 109278700(ATM)
AJU: 106983963(ATM)
HHV: 120229863(ATM)
BTA: 526824(ATM)
BOM: 102270218 102278968(ATM)
BIU: 109569718(ATM)
BBUB: 102399207(ATM)
CHX: 102190803(ATM)
OAS: 101105847(ATM) 114118362
ODA: 120876210(ATM)
CCAD: 122450584(ATM)
SSC: 100101922(ATM)
CFR: 102511995(ATM)
CBAI: 105080329(ATM)
CDK: 105096603(ATM)
BACU: 102999600(ATM)
LVE: 103070327(ATM)
OOR: 101271555(ATM)
DLE: 111168050(ATM)
PCAD: 102975752(ATM)
PSIU: 116757857(ATM)
ECB: 100061765(ATM)
EPZ: 103561090(ATM)
EAI: 106843652(ATM)
MYB: 102258109(ATM)
MYD: 102764679(ATM)
MMYO: 118664416(ATM)
MLF: 102440135(ATM)
MNA: 107541208(ATM)
PKL: 118712974(ATM)
HAI: 109371552(ATM)
DRO: 112314280(ATM)
SHON: 118988241(ATM)
AJM: 119059255(ATM)
PDIC: 114498399(ATM)
PHAS: 123818096(ATM)
MMF: 118628940(ATM)
RFQ: 117030407(ATM)
PALE: 102898588(ATM)
PGIG: 120619030(ATM)
PVP: 105297463(ATM)
RAY: 107518682(ATM)
MJV: 108394726(ATM)
TOD: 119240886(ATM)
SARA: 101538280(ATM)
LAV: 100663914(ATM)
DNM: 101418100(ATM)
MDO: 100026797(ATM)
GAS: 123241475(ATM)
SHR: 100925167(ATM)
PCW: 110214947(ATM)
OAA: 100078971(ATM)
GGA: 395401(ATM)
PCOC: 116237209(ATM)
CJO: 107308373(ATM)
NMEL: 110389599
APLA: 101803327(ATM)
ACYG: 106040363
AFUL: 116490910(ATM)
TGU: 100217707(ATM)
LSR: 110470034(ATM)
SCAN: 103827295(ATM)
PMOA: 120506699(ATM)
OTC: 121341234(ATM)
PRUF: 121364252(ATM)
FAB: 101810210(ATM)
PHI: 102099369(ATM)
PMAJ: 107201670(ATM)
CCAE: 111924074(ATM)
CCW: 104690043(ATM)
ETL: 114066109(ATM)
ZAB: 102062101(ATM)
FCH: 102058832(ATM)
CLV: 102086207(ATM)
EGZ: 104130058(ATM)
NNI: 104023113(ATM)
ACUN: 113478019(ATM)
TALA: 104361507(ATM)
PADL: 103926402(ATM)
ACHC: 115353268(ATM)
AAM: 106493490(ATM)
AROW: 112967802(ATM)
NPD: 112943759(ATM)
DNE: 112983222(ATM)
ASN: 102387373
AMJ: 102567445(ATM)
CPOO: 109306698(ATM)
GGN: 109302675(ATM)
PSS: 102462597(ATM)
CMY: 102933488(ATM)
CPIC: 101949002(ATM)
TST: 117871149(ATM)
CABI: 116830982(ATM)
MRV: 120398929(ATM)
ACS: 100556408 100560063(atm)
PVT: 110084084(ATM)
SUND: 121926777(ATM)
PBI: 103049413(ATM)
PMUR: 107284835(ATM)
TSR: 106545720(ATM)
PGUT: 117661064(ATM)
VKO: 123028999(ATM)
PMUA: 114595683(ATM)
ZVI: 118084876(ATM)
GJA: 107113474(ATM)
STOW: 125431170(ATM)
XLA: 398148(atm.L)
XTR: 100490767(atm)
NPR: 108786846(ATM)
RTEM: 120929264(ATM)
BBUF: 120996370(ATM)
BGAR: 122930567(ATM)
DRE: 403064(atm)
SRX: 107726121(atm)
SANH: 107655812(atm)
SGH: 107562809(atm)
CCAR: 109079736
CAUA: 113115344(atm)
PPRM: 120464686(atm)
MAMB: 125248362(atm)
IPU: 108280662(atm)
PHYP: 113543379(atm)
SMEO: 124402985(atm)
TFD: 113653740(atm)
AMEX: 103045062(atm)
TRU: 101079070(atm)
LCO: 104921142(atm)
NCC: 104962374(atm)
CGOB: 115018004(atm)
ELY: 117260068(atm)
PLEP: 121943262(atm)
SLUC: 116043870(atm)
ECRA: 117942607(atm)
PFLV: 114552350(atm)
GAT: 120819465(atm)
PPUG: 119215964(atm)
MSAM: 119882548(atm)
CUD: 121521093(atm)
MZE: 101485570(atm) 112435930
ONL: 100694314(atm)
OAU: 116330374(atm)
OLA: 101167063(atm)
OML: 112149326(atm)
XMA: 102236667(atm)
XCO: 114161922(atm)
XHE: 116707704(atm)
PRET: 103474390(atm)
PFOR: 103153984(atm)
PLAI: 106935516(atm)
PMEI: 106928690(atm)
GAF: 122832150(atm)
CVG: 107096999(atm)
CTUL: 119783853(atm)
GMU: 124884541(atm)
NFU: 107380541(atm)
KMR: 108238195(atm)
ALIM: 106520608(atm) 106522150
NWH: 119411548(atm)
AOCE: 111588942(atm)
CSEM: 103377587(atm)
POV: 109634588(atm)
SSEN: 122773479(atm)
HHIP: 117772580(atm)
LCF: 108873779(atm)
SDU: 111239103(atm)
SLAL: 111654570(atm)
XGL: 120792134(atm)
HCQ: 109512895(atm)
BPEC: 110171887(atm)
MALB: 109960285(atm)
SASA: 106612994(atm)
OTW: 112267156(atm)
OMY: 110503994(atm)
OGO: 124004686
ONE: 115141870(atm)
SALP: 111958113(atm)
SNH: 120028560(atm)
ELS: 105021770(atm)
SFM: 108932475(atm)
PKI: 111844902(atm)
AANG: 118210103(atm)
LOC: 102685994(atm)
PSPA: 121302935(atm)
LCM: 102347668(ATM)
CMK: 103186517(atm)
RTP: 109934178(atm)
BFO: 118422781
BBEL: 109472771
CIN: 104266316
SCLV: 120332130
APLC: 110974570
SKO: 100369761
DME: Dmel_CG6535(tefu)
DER: 6553109
DSE: 6606302
DSI: Dsimw501_GD20371(Dsim_GD20371)
DSR: 110188688
DPE: 6594101
DMN: 108155150
DWI: 6651745
DGR: 6569928
DAZ: 108618692
DNV: 108657349
DHE: 111593396
CCAT: 101460055
BOD: 106622478
MDE: 101901575
SCAC: 106086305
LCQ: 111680770
ACOZ: 120955735
AARA: 120900113
AAG: 5565620
CPII: 120424566
CNS: 116338418
AME: 725613
ACER: 108002987
ALAB: 122711916
BIM: 100741124
BBIF: 117211442
BVK: 117237134
BVAN: 117159663
BTER: 100645615
BPYO: 122572207
CCAL: 108625459
OBB: 114874890
MGEN: 117228900
NMEA: 116426162
CGIG: 122401923
SOC: 105208138
MPHA: 105835591
AEC: 105153144
ACEP: 105621874
PBAR: 105430322
VEM: 105557492
HST: 105192021
DQU: 106743590
CFO: 105248156
FEX: 115241246
LHU: 105672391
PGC: 109858879
OBO: 105279930
PCF: 106791964
PFUC: 122514812
VPS: 122636719
NVI: 100114506
CSOL: 105359752
TPRE: 106654953
MDL: 103579701
CGLO: 123264779
FAS: 105270883
DAM: 107041525
AGIF: 122861083
CCIN: 107271877
TCA: 660142
DPA: 109546392
SOY: 115874995
ATD: 109609308
CSET: 123314851
AGB: 108912590
LDC: 111504057
NVL: 108562636
APLN: 108733647
PPYR: 116177601
OTU: 111426931
BMOR: 101746600
BMAN: 114252745
MSEX: 115447113
BANY: 112043551
PMAC: 106710662
PPOT: 106099445
PXU: 106127434
PRAP: 110999834
ZCE: 119833533
TNL: 113501122
SLIU: 111361763
OFU: 114352019
PXY: 105385913
API: 100167029
DNX: 107164236
AGS: 114119972
RMD: 113551183
BTAB: 109031285
DCI: 103509647
CLEC: 106664980
HHAL: 106683940
NLU: 111051994
FOC: 113218424
ZNE: 110831099
CSEC: 111874905
FCD: 110850413
DMK: 116926286
PVM: 113807048
PJA: 122249578
PCHN: 125044179
HAME: 121854586
PCLA: 123774538
PTRU: 123509273
EAF: 111700887
LSM: 121122264
DSV: 119461848
RSAN: 119397205
RMP: 119173611
VDE: 111245313
VJA: 111270379
CSCU: 111627528
CEL: CELE_Y48G1BL.2(atm-1)
GAE: 121370659
HRJ: 124277804
CRG: 105317516
MYI: 110451548
PMAX: 117327466
OBI: 106881129
OSN: 115232583
LAK: 106167267
EGL: EGR_01160
NVE: 5507831
EPA: 110239409
ATEN: 116305822
ADF: 107332199
AMIL: 114954129
SPIS: 111337590
DGT: 114521310
HMG: 100201385
AQU: 100641266
ATH: AT3G48190(ATM)
ALY: 9313670
CRB: 17887531
BRP: 103873550
BOE: 106335109
RSZ: 108829153
THJ: 104818218
CIT: 102620162
PVY: 116136704
MINC: 123204513
TCC: 18603913
GRA: 105800021
GAB: 108456394
DZI: 111311725
EGR: 104426267
GMX: 100788458
GSJ: 114409825
VRA: 106761920
VAR: 108331474
VUN: 114195970
APRC: 113851297
CAM: 101498080
LJA: Lj0g3v0182159.1(Lj0g3v0182159.1) Lj4g3v0165070.1(Lj4g3v0165070.1)
ADU: 107471056
AIP: 107622505
LANG: 109328123
FVE: 101295891
RCN: 112169915
PPER: 18775824
PMUM: 103338375
PAVI: 110766866
PDUL: 117626929
MDM: 103428334
ZJU: 107418355
MNT: 21398136
CSV: 101208785
CMO: 103493908
BHJ: 120070992
MCHA: 111007159
CMAX: 111497793
CMOS: 111435229
CPEP: 111793694
RCU: 8289003
JCU: 105640381
HBR: 110657098
MESC: 110617578
POP: 7454490
PEU: 105128541
PALZ: 118057498
JRE: 108991465
QLO: 115965445
TWL: 119983858
VVI: 100250198
VRI: 117904579
SLY: 101253578
SPEN: 107014410
SOT: 102596182
CANN: 107862525
NSY: 104223562
NTO: 104114108
NAU: 109206336
INI: 109191135
ITR: 116010243
SIND: 105157405
OEU: 111368111
EGT: 105952228
HAN: 110912584
ECAD: 122607791
LSV: 111913545
CCAV: 112511833
DCR: 108195966
CSIN: 114285815
BVG: 104894278
SOE: 110789457
NNU: 104587223
MING: 122076805
TSS: 122654333
NCOL: 116261494
OSA: 4326151
DOSA: Os01t0106700-00(Os01g0106700)
OBR: 102715629
BDI: 100845900
ATS: 109742816
SBI: 8072354
ZMA: 103651852
SITA: 101786621
SVS: 117857323
PHAI: 112891756
PDA: 103702060
EGU: 105056273
MUS: 103987359
DCT: 110106501
PEQ: 110032439
AOF: 109845768
ATR: 18434891
PPP: 112274382
MNG: MNEG_6430
SCE: YBL088C(TEL1)
SEUB: DI49_0100
KMX: KLMA_70154(TEL1)
NCS: NCAS_0E02450(NCAS0E02450)
NDI: NDAI_0E04020(NDAI0E04020)
TPF: TPHA_0K00690(TPHA0K00690)
TBL: TBLA_0D00420(TBLA0D00420)
TDL: TDEL_0C02790(TDEL0C02790)
KAF: KAFR_0L01900(KAFR0L01900)
KNG: KNAG_0B02200(KNAG0B02200)
PIC: PICST_59212(TEL1)
CAL: CAALFM_C603010WA(TEL1)
SLB: AWJ20_1822(TEL1)
NCR: NCU00274(mus-21)
NTE: NEUTE1DRAFT63387(NEUTE1DRAFT_63387)
MGR: MGG_14764
SSCK: SPSK_04788
MAW: MAC_02545
MAJ: MAA_03471
CMT: CCM_07553
MBE: MBM_07033
ANI: AN0038.2
ANG: ANI_1_1604124(An14g06540)
ALUC: AKAW2_41265S(TEL1)
ACHE: ACHE_41297A(TEL1)
APUU: APUU_12130A(TEL1)
CIM: CIMG_12324(CIMG09299)
ABE: ARB_03387
TVE: TRV_08071
PNO: SNOG_10359(SNOG_10357 SNOG_10358)
PTE: PTT_08591
ZTR: MYCGRDRAFT_68352(TOR2)
SPO: SPCC23B6.03c(tel1)
CNE: CNF02070
CNB: CNBF2640
TASA: A1Q1_05838
ABP: AGABI1DRAFT70197(AGABI1DRAFT_70197)
ABV: AGABI2DRAFT205907(AGABI2DRAFT_205907)
MBR: MONBRDRAFT_34416(ATM)
EHI: EHI_017670(199.t00007)
SMIN: v1.2.029032.t1(symbB.v1.2.029032.t1)
SPAR: SPRG_22315
 » show all
Reference
PMID:8589678
  Authors
Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G
  Title
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.
  Journal
Hum Mol Genet 4:2025-32 (1995)
DOI:10.1093/hmg/4.11.2025
  Sequence
[hsa:472]
Reference
  Authors
Sun Y, Xu Y, Roy K, Price BD
  Title
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
  Journal
Mol Cell Biol 27:8502-9 (2007)
DOI:10.1128/MCB.01382-07
  Sequence
[hsa:472]

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