KEGG ORTHOLOGY: K05032

ORTHOLOGY: K05032

Entry

K05032                      KO

Symbol

ABCC8, SUR1

Name

ATP-binding cassette subfamily C (CFTR/MRP) member 8

Pathway

map02010

ABC transporters

map04911

Insulin secretion

map04930

Type II diabetes mellitus

Disease

H00409

Type 2 diabetes mellitus

H00410

Maturity onset diabetes of the young (MODY)

H00512

Permanent neonatal diabetes mellitus

H00513

Transient neonatal diabetes mellitus

H01267

Familial hyperinsulinemic hypoglycemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
Transporters [BR:ko02000]
ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC8, 9 subgroups
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8

Other DBs

TC:	3.A.1.208.4

Genes

HSA:	6833(ABCC8)

PTR:	451056(ABCC8)

PPS:	100980650(ABCC8)

GGO:	101128886(ABCC8)

PON:	100433186(ABCC8)

PPYG:

129007644(ABCC8)

NLE:	100603002(ABCC8)

HMH:	116476468(ABCC8)

SSYN:

129484360(ABCC8)

MCC:	654490(ABCC8)

MCF:	102118880(ABCC8)

MTHB:

126934629

MNI:	105486959(ABCC8)

CSAB:

103239480(ABCC8)

CATY:

105598894(ABCC8)

PANU:

101010659(ABCC8)

TGE:	112606507(ABCC8)

MLEU:

105548762(ABCC8)

RRO:	104667632(ABCC8)

RBB:	108528235(ABCC8)

TFN:	117081714(ABCC8)

PTEH:

111555065(ABCC8)

CANG:

105508627(ABCC8)

CJC:	100386093(ABCC8)

SBQ:	101041998(ABCC8)

CIMI:

108302262(ABCC8)

ANAN:

105719998(ABCC8)

CSYR:

103274377(ABCC8)

MMUR:

105879980(ABCC8)

LCAT:

123642490(ABCC8)

PCOQ:

105818231(ABCC8)

OGA:	100940864(ABCC8)

MMU:	20927(Abcc8)

MCAL:

110297901(Abcc8)

MPAH:

110321515(Abcc8)

RNO:	25559(Abcc8)

MCOC:

116102244(Abcc8)

ANU:	117718725(Abcc8)

ASYL:

127668752(Abcc8)

MUN:	110550473(Abcc8)

CGE:	100764394(Abcc8)

MAUA:

101835030(Abcc8)

PROB:

127213846(Abcc8)

PLEU:

114700534(Abcc8)

MORG:

121435231(Abcc8)

MFOT:

126493312

AAMP:

119802563(Abcc8)

NGI:	103734450(Abcc8)

HGL:	101705546(Abcc8)

CPOC:

100722700(Abcc8)

CCAN:

109695032(Abcc8)

DORD:

105999175(Abcc8)

DSP:	122117689(Abcc8)

DMER:

138834074(Abcc8)

PLOP:

125361636(Abcc8)

NCAR:

124960270

MMMA:

107135681(Abcc8)

ITI:	101966999(Abcc8)

OCU:

100341472

OPI:	101518410(ABCC8)

TUP:	102490959(ABCC8)

GVR:	103596135(ABCC8)

CFA:	485402(ABCC8)

CLUD:

112667698(ABCC8)

VVP:	112927030(ABCC8)

VLG:	121476634(ABCC8)

NPO:	129505154(ABCC8)

AML:	100480112(ABCC8)

UMR:	103679402(ABCC8)

UAH:	113246622(ABCC8)

UAR:	123791679(ABCC8)

ELK:

111149755

LLV:

125078210

MPUF:

101681504(ABCC8)

MNP:	132022294(ABCC8)

MLK:	131809980(ABCC8)

NVS:	122912758(ABCC8)

ORO:	101366537(ABCC8)

EJU:	114219319(ABCC8)

ZCA:	113914386(ABCC8)

MLX:	118003947(ABCC8)

NSU:	110576612(ABCC8)

FCA:	101096101(ABCC8)

PYU:	121043704(ABCC8)

PCOO:

112865636(ABCC8)

PBG:	122484402(ABCC8)

PVIV:

125176625(ABCC8)

LRUF:

124505376

LGF:	123601437(ABCC8)

AJU:

106977473

PTG:	102967889(ABCC8)

PPAD:

109271201(ABCC8)

PUC:

125913358

PLEZ:

122200684(ABCC8)

HHV:	120234808(ABCC8)

BTA:	538996(ABCC8)

BOM:	102274573(ABCC8)

BIU:	109569744(ABCC8)

BBUB:

102404986(ABCC8)

BBIS:

104981430(ABCC8)

CHX:	102185675(ABCC8)

OAS:	101120522(ABCC8)

BTAX:

128060025(ABCC8)

CSUM:

138093197(ABCC8)

ODA:	120876401(ABCC8)

CCAD:

122450186(ABCC8)

MREE:

136174195(ABCC8)

OVR:	110144736(ABCC8)

MBEZ:

129554470(ABCC8)

SSC:	100158245(ABCC8)

CFR:	102523396(ABCC8)

CBAI:

105076592(ABCC8)

CDK:	105086704(ABCC8)

VPC:	102534857(ABCC8)

BACU:

102999613(ABCC8)

BMUS:

118900238(ABCC8)

LVE:	103081595(ABCC8)

OOR:	101271740(ABCC8)

LALB:

132525967(ABCC8)

GMF:	115839616(ABCC8)

DDP:	132429129(ABCC8)

DLE:	111165221(ABCC8)

PCAD:

102975396(ABCC8)

PSIU:

116758486(ABCC8)

PPHC:

136126759(ABCC8)

NASI:

112390599(ABCC8)

ECB:	100071788(ABCC8)

EPZ:	103543801(ABCC8)

EAI:	106835490(ABCC8)

MYB:	102251988(ABCC8)

MYD:

102759330

MMYO:

118664886(ABCC8)

MLF:	102433282(ABCC8)

MDT:	132241023(ABCC8)

MYUM:

139019046(ABCC8)

PKL:	118713153(ABCC8)

EFUS:

103292741(ABCC8)

MNA:	107546729(ABCC8)

DRO:	112303290(ABCC8)

SHON:

118989712(ABCC8)

AJM:	119053086(ABCC8)

PDIC:

114499434(ABCC8)

PHAS:

123810127(ABCC8)

MMF:	118627689(ABCC8)

PPAM:

129080528(ABCC8)

HAI:	109388106(ABCC8)

RFQ:	117031244(ABCC8)

PALE:

102883696(ABCC8)

PGIG:

120593603(ABCC8)

PVP:	105304230(ABCC8)

RAY:	107508030(ABCC8)

MJV:	108404861(ABCC8)

TOD:	119255508(ABCC8)

SARA:

101548091(ABCC8)

SFUM:

130039044(ABCC8)

SETR:

126018997(ABCC8)

LAV:	100660003(ABCC8)

TMU:

101359595

ETF:	101655157(ABCC8)

DNM:

101437876

MDO:	100020181(ABCC8)

GAS:	123252514(ABCC8)

SHR:	100915705(ABCC8)

AFZ:

127542074

PCW:	110220976(ABCC8)

TVP:	118853601(ABCC8)

PBRV:

138149961(ABCC8)

OAA:	100078637(ABCC8)

TACU:

119943379(ABCC8)

GGA:	423072(ABCC8)

PCOC:

116242874(ABCC8)

MGP:	100548594(ABCC8)

CJO:	107314654(ABCC8)

TPAI:

128085637(ABCC8)

LMUT:

125694531(ABCC8)

NMEL:

110401613(ABCC8)

APLA:

101804688(ABCC8)

ACYG:

106033850(ABCC8)

CATA:

118249879(ABCC8)

AFUL:

116490265(ABCC8)

TGU:	100223853(ABCC8)

LSR:	110468059(ABCC8)

SCAN:

103827026(ABCC8)

PMOA:

120501316(ABCC8)

OTC:	121341472(ABCC8)

PRUF:

121360941(ABCC8)

ATRC:

139590339(ABCC8)

GFR:	102036551(ABCC8)

FAB:	101812634(ABCC8)

OMA:	130254214(ABCC8)

PHI:	102105363(ABCC8)

PMAJ:

107206079(ABCC8)

CCAE:

111930701(ABCC8)

CCW:	104687870(ABCC8)

CBRC:

103624946(ABCC8)

ACOE:

138111313(ABCC8)

ETL:	114068369(ABCC8)

ZAB:	102064576(ABCC8)

ZLE:	135448748(ABCC8)

ACHL:

103803549(ABCC8)

SVG:	106853227(ABCC8)

MMEA:

130575407(ABCC8)

HRT:	120754050(ABCC8)

SATI:

136362385(ABCC8)

CCIC:

134045803(ABCC8)

FPG:	101920296(ABCC8)

FCH:	102047812(ABCC8)

CCRI:

104166418(ABCC8)

SHAB:

115607050(ABCC8)

ACUN:

113480965(ABCC8)

TALA:

104363920(ABCC8)

ACHC:

115351751(ABCC8)

HALD:

104319647(ABCC8)

HLE:	104829535(ABCC8)

AGEN:

126047411

HHAR:

128152612(ABCC8)

GCL:

127017228

CSTI:

104553480(ABCC8)

LDI:	104340437(ABCC8)

MNB:	103767878(ABCC8)

DPUB:

104304433(ABCC8)

PPUS:

135186151(ABCC8)

AVIT:

104267757(ABCC8)

BRHI:

104500601

EGZ:	104123163(ABCC8)

NNI:	104010907(ABCC8)

PCAO:

104052950(ABCC8)

PADL:

103920770(ABCC8)

AFOR:

103906739(ABCC8)

FGA:

104076374

GSTE:

104265069(ABCC8)

CBOY:

140653449(ABCC8)

CLV:	102097135(ABCC8)

CNIC:

135989179(ABCC8)

MUI:

104547326

PGUU:

104465852(ABCC8)

PLET:

104622298(ABCC8)

EHS:

104513575

CUCA:

104068954(ABCC8)

TEO:

104383690

BREG:

104639314(ABCC8)

OHA:	104330144(ABCC8)

ACAR:

104525205

CPEA:

104386756(ABCC8)

CVF:	104292638(ABCC8)

RTD:	128909097(ABCC8)

CRID:

134515361(ABCC8)

AAM:	106497135(ABCC8)

AROW:

112972383(ABCC8)

NPD:	112948837(ABCC8)

TGT:	104580441(ABCC8)

DNE:	112985704(ABCC8)

SCAM:

104140425(ABCC8)

ASN:	102368362(ABCC8)

AMJ:	106736701(ABCC8)

CPOO:

109321393(ABCC8)

GGN:	109299129(ABCC8)

PSS:	102455761(ABCC8)

CMY:	102936267(ABCC8)

DCC:	119857468(ABCC8)

CPIC:

101949000(ABCC8)

TST:	117877251(ABCC8)

CABI:

116835930(ABCC8)

MRV:	120404189(ABCC8)

ACS:	100562467(abcc8)

ASAO:

132770679(ABCC8)

PVT:	110083986(ABCC8)

SUND:

121919682(ABCC8)

PBI:	103057429(ABCC8)

PMUR:

107299624(ABCC8)

CTIG:

120308497(ABCC8)

TSR:	106545199(ABCC8)

PGUT:

117666150(ABCC8)

PCAE:

139309440(ABCC8)

APRI:

131185761(ABCC8)

PTEX:

113440277(ABCC8)

NSS:	113412574(ABCC8)

VKO:	123021194(ABCC8)

PMUA:

114598697(ABCC8)

PRAF:

128415910(ABCC8)

ZVI:	118087500(ABCC8)

HCG:	128339366(ABCC8)

GJA:	107120528(ABCC8)

STOW:

125426709(ABCC8)

EMC:	129324773(ABCC8)

XLA:	108713435 108714951

XTR:	101730668(abcc8)

RTEM:

120921981(ABCC8)

ACAT:

141111798(ABCC8)

BBUF:

120980687(ABCC8)

BGAR:

122920717 122921146(ABCC8)

DTC:	141077390(ABCC8)

PWL:	138284676(ABCC8)

MUO:	115468922(ABCC8)

GSH:	117352154(ABCC8)

DRE:	100329706(abcc8b) 553281(abcc8)

SRX:	107740359 107744191 107758750(abcc8)

SANH:

107675245 107675473

SGH:	107549258 107569903

CCAR:

109053380 109078783 109088442

CAUA:

113043572 113067090 113087741 113118620

CGIB:

127947493 127977920 128014210

PTET:

122331105 122362581(abcc8b)

LROH:

127156710(abcc8) 127180699(abcc8b)

GRF:	141301442(abcc8)

OMC:	131524287(abcc8b) 131534611(abcc8)

PPRM:

120459923 120473380(abcc8)

RKG:	130075671(abcc8b) 130086027(abcc8)

MAMB:

125247757(abcc8) 125254541(abcc8b)

CIDE:

127499386 127506740

CERY:

137014655(abcc8) 137023537(abcc8b)

MASI:

127417192 127436184 127437715 127455686

TROS:

130552301(abcc8) 130562542(abcc8b)

TDW:	130414479(abcc8) 130435984(abcc8b)

MANU:

129418733(abcc8b) 129433821(abcc8) 141363397

PDAB:

135769442(abcc8b) 135781613(abcc8)

IPU:	108264060 108274972

IFU:	128606483(abcc8b) 128618598(abcc8)

PHYP:

113526366 113529828(abcc8)

SMEO:

124392507(abcc8) 124395459(abcc8b)

TFD:	113660185(abcc8) 113662125(abcc8b)

TVC:	132851584(abcc8b) 132857427(abcc8)

CGAR:

128506431(abcc8) 128527661(abcc8b)

NGRA:

132881951(abcc8) 132887643(abcc8b)

TRN:	134309656(abcc8) 134323510(abcc8b)

AMEX:

103030655(abcc8) 103043789(abcc8b)

CMAO:

118811550(abcc8) 118817965

EEE:	113580554(abcc8)

CHAR:

105904752(abcc8) 105906456

SPIL:

134094540(abcc8) 134095452

TRU:	101077334 115251137

TFS:	130536500(abcc8)

TNG:	GSTEN00012676G001

LCO:	104936259(abcc8)

TBEN:

117491265(abcc8)

CGOB:

115009613(abcc8)

PGEO:

117448217(abcc8)

GACU:

117545884(abcc8)

EMAC:

134859792(abcc8)

ELY:	117261702(abcc8)

EFO:	125888149(abcc8)

PLEP:

121949949(abcc8)

SLUC:

116038378(abcc8)

ECRA:

117949295(abcc8)

ESP:

116693530

PFLV:

114559780(abcc8)

GAT:	120808796 120812315

PPUG:

119195781(abcc8)

AFB:	129107901(abcc8)

CLUM:

117732266(abcc8)

PSWI:

130195562(abcc8)

CANA:

137804142(abcc8)

CVE:	137880907(abcc8)

MSAM:

119894090(abcc8)

SCHU:

122874267(abcc8)

CUD:	121514983(abcc8)

SPUL:

138612449(abcc8)

LMIX:

132973192(abcc8)

ALAT:

119024008(abcc8)

ASTR:

137594041(abcc8)

MZE:	101476511(abcc8)

ONL:	100705598(abcc8)

OAU:	116327611(abcc8)

OLA:	101167867(abcc8)

OML:	112152062(abcc8)

CSAI:

133444019(abcc8)

XMA:	102224164(abcc8)

XCO:	114156649(abcc8)

XHE:

116734241

PRET:

103466172(abcc8)

PFOR:

103144417(abcc8)

PLAI:

106948429(abcc8)

PMEI:

106916767(abcc8)

GAF:	122835889(abcc8)

PPRL:

129356036(abcc8)

CVG:	107089489(abcc8)

CTUL:

119796775(abcc8)

GMU:	124884253(abcc8)

NFU:	107389030(abcc8)

KMR:	108237504(abcc8)

ALIM:

106515675(abcc8)

NWH:	119416013(abcc8)

AOCE:

111563344(abcc8)

EJA:	138206321(abcc8)

BFRE:

138634682(abcc8)

MCEP:

125014849(abcc8)

CSEM:

103398783(abcc8)

POV:	109638969(abcc8)

SSEN:

122775912(abcc8)

SSOE:

131470491(abcc8)

HHIP:

117763773(abcc8)

HSP:	118109292(abcc8)

PPLT:

128444996(abcc8)

SMAU:

118314890(abcc8)

LCF:

108875227

SDU:	111228432(abcc8)

SLAL:

111661756(abcc8)

XGL:	120793668(abcc8)

HCQ:	109530389(abcc8)

SSCV:

125971165(abcc8)

SBIA:

133502054(abcc8)

PEE:	133402697(abcc8)

PTAO:

133477592(abcc8)

BPEC:

110165898(abcc8)

ENY:

140349342

MALB:

109967883(abcc8)

BSPL:

114857693(abcc8)

SJO:	128359295(abcc8)

SSCO:

133982310(abcc8)

GMH:	115550720(abcc8)

SASA:

106561050 106584588

STRU:

115192777 115197051

OTW:	112218237 112259407

OMY:	110492500 110522733

OGO:	124037570 124044709

ONE:	115134487(abcc8) 115144802

OKI:	109867182 109898452

OKE:	118358785 118396446

OMM:	135509585 135556641

OCLA:

139369398 139407565

SALP:

111962152 111971785

SNH:	120052367 120066623(abcc8)

CCLU:

121532059 121540705(abcc8)

ELS:	105030992(abcc8)

OEP:	134020690(abcc8)

SFM:	108942292(abcc8)

PKI:	111859508(abcc8)

AANG:

118215344(abcc8)

AROT:

135241592(abcc8)

CCOG:

133111356(abcc8)

LOC:	102684969(abcc8)

PSPA:

121294880 121330387

ARUT:

117432376 117434723

PSEX:

120516667(abcc8)

LCM:	102365463(ABCC8)

CMK:	103174891(abcc8)

RTP:	109935460(abcc8)

CPLA:

122557842(abcc8)

HOC:	132811042 132824420(abcc8)

LERI:

129705734(abcc8)

HAKA:

140729566(abcc8)

PMRN:

116940098 116945488

LRJ:	133350306 133351506

BBEL:

109470274

SPU:

100892057

AJJ:	139961998 139977502

APLC:

110974025 110974039

SKO:

102804902

PFLL:

139117207 139117670 139134494 139135638 139135640

LSM:	121128549(Sur)

RMP:

DFR:

BGT:

OSN:

LJP:

Reference

PMID:18990670

Authors

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM

Title

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Journal

Philos Trans R Soc Lond B Biol Sci 364:257-67 (2009)
DOI:10.1098/rstb.2008.0142

Reference

PMID:7716547

Authors

Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP 4th, Boyd AE 3rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA

Title

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

Journal

Science 268:423-6 (1995)
DOI:10.1126/science.7716547

Sequence

[hsa:6833]

All links

Ontology (1)   
   TC (1)   
Gene (866)   
   MGENES (467)   
   RefGene (393)   
   OC (6)   
All databases (867)   

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