KEGG   ORTHOLOGY: K05859
Entry
K05859                      KO                                     
Symbol
PLCG2
Name
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04020  Calcium signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04070  Phosphatidylinositol signaling system
map04072  Phospholipase D signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04380  Osteoclast differentiation
map04611  Platelet activation
map04613  Neutrophil extracellular trap formation
map04625  C-type lectin receptor signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04919  Thyroid hormone signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05110  Vibrio cholerae infection
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Reaction
R03332  1-phosphatidyl-D-myo-inositol inositolphosphohydrolase
R03435  1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
R10952  1-phosphatidyl-1D-myo-inositol-4-phosphate inositolbisphosphohydrolase
Disease
H01743  Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04613 Neutrophil extracellular trap formation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04625 C-type lectin receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04062 Chemokine signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09158 Development and regeneration
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05171 Coronavirus disease - COVID-19
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05131 Shigellosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Other DBs
GO: 0004435
Genes
HSA: 5336(PLCG2)
PTR: 454268(PLCG2)
PPS: 100984694(PLCG2)
GGO: 101133643(PLCG2)
PON: 100457650(PLCG2)
PPYG: 129015232(PLCG2)
NLE: 100604145(PLCG2)
HMH: 116470775(PLCG2)
SSYN: 129493473(PLCG2)
MCC: 714173(PLCG2)
MCF: 102117471(PLCG2)
MTHB: 126943961
MNI: 105491204(PLCG2)
CSAB: 103233371(PLCG2)
CATY: 105589398(PLCG2)
PANU: 101004091(PLCG2)
TGE: 112614034(PLCG2)
MLEU: 105546817(PLCG2)
RRO: 104671624(PLCG2)
RBB: 108539491(PLCG2)
TFN: 117088112(PLCG2)
PTEH: 111552578(PLCG2)
CANG: 105511970(PLCG2)
CJC: 100390347(PLCG2)
SBQ: 101030999(PLCG2)
CIMI: 108313460(PLCG2)
ANAN: 105726497(PLCG2)
CSYR: 103267377(PLCG2)
MMUR: 105859475(PLCG2)
LCAT: 123625473(PLCG2)
PCOQ: 105813491(PLCG2)
OGA: 100948829(PLCG2)
MMU: 234779(Plcg2)
MCAL: 110300336(Plcg2)
MPAH: 110337392(Plcg2)
RNO: 29337(Plcg2)
MCOC: 116070251(Plcg2)
ANU: 117723064(Plcg2)
MUN: 110550263(Plcg2)
CGE: 100752475(Plcg2)
MAUA: 101831758(Plcg2)
PROB: 127234658(Plcg2)
PLEU: 114697457(Plcg2)
MORG: 121447066(Plcg2)
MFOT: 126502936
AAMP: 119801950(Plcg2)
NGI: 103725694 103748739
HGL: 101715321(Plcg2)
CPOC: 100726796(Plcg2)
CCAN: 109696649(Plcg2)
DORD: 105982979(Plcg2)
PLOP: 125357867(Plcg2)
NCAR: 124966613
MMMA: 107150868(Plcg2)
OCU: 100340139
OPI: 101526399(PLCG2)
TUP: 102483786(PLCG2)
GVR: 103591521(PLCG2)
CFA: 489692(PLCG2)
CLUD: 112646723(PLCG2)
VVP: 112911890 112912331
VLG: 121500177(PLCG2)
NPO: 129497753(PLCG2)
AML: 100481994(PLCG2)
UMR: 103662093(PLCG2)
UAH: 113252535(PLCG2)
UAR: 123791349(PLCG2)
ELK: 111152978
LLV: 125089755
MPUF: 101670617(PLCG2)
MNP: 132005665(PLCG2)
MLK: 131818792(PLCG2)
NVS: 122911198(PLCG2)
ORO: 101378505(PLCG2)
EJU: 114202334(PLCG2)
ZCA: 113936075(PLCG2)
MLX: 118023528(PLCG2)
NSU: 110593864(PLCG2)
FCA: 101080675(PLCG2)
PYU: 121009974(PLCG2)
PCOO: 112857487(PLCG2)
PBG: 122494519(PLCG2)
PVIV: 125152537(PLCG2)
LRUF: 124511524
PTG: 102963653(PLCG2)
PPAD: 109245637(PLCG2)
PUC: 125916347
AJU: 106984018
HHV: 120228197(PLCG2)
BTA: 100337091(PLCG2)
BOM: 102285300(PLCG2)
BIU: 109572707(PLCG2)
BBUB: 102396307(PLCG2)
BBIS: 104996518(PLCG2)
CHX: 102180337(PLCG2)
OAS: 101122126(PLCG2)
BTAX: 128063111(PLCG2)
ODA: 120873247(PLCG2)
CCAD: 122420118(PLCG2)
MBEZ: 129547229(PLCG2)
SSC: 100518663(PLCG2)
CFR: 102514470(PLCG2)
CBAI: 105078942(PLCG2)
CDK: 105089440(PLCG2)
VPC: 102540897(PLCG2)
BACU: 103014764(PLCG2)
BMUS: 118885802(PLCG2)
LVE: 103070997(PLCG2)
OOR: 101285216(PLCG2)
DLE: 111179463(PLCG2)
PCAD: 102983230(PLCG2)
PSIU: 116744707(PLCG2)
NASI: 112393390(PLCG2)
ECB: 100055670(PLCG2)
EPZ: 103558212(PLCG2)
EAI: 106832855
MYB: 102261553(PLCG2)
MYD: 102773476(PLCG2)
MMYO: 118674206(PLCG2)
MLF: 102420000(PLCG2)
MDT: 132217215(PLCG2)
PKL: 118720533(PLCG2)
EFUS: 103284403(PLCG2)
MNA: 107524904(PLCG2)
DRO: 112300725(PLCG2)
SHON: 118983037(PLCG2)
AJM: 119047103(PLCG2)
PDIC: 114488244(PLCG2)
PHAS: 123805718(PLCG2)
MMF: 118639621(PLCG2)
PPAM: 129075160(PLCG2)
HAI: 109378365(PLCG2)
RFQ: 117034806(PLCG2)
PALE: 102883128(PLCG2)
PGIG: 120622970(PLCG2)
PVP: 105289863(PLCG2)
RAY: 107521319(PLCG2)
MJV: 108400464(PLCG2)
TOD: 119249121(PLCG2)
SARA: 101554088(PLCG2)
SETR: 126027269(PLCG2)
LAV: 100658990(PLCG2)
TMU: 101346393
ETF: 101644253(PLCG2)
DNM: 101428386(PLCG2)
MDO: 100027579(PLCG2)
GAS: 123237042(PLCG2)
SHR: 100919206(PLCG2)
AFZ: 127548673
PCW: 110212621(PLCG2)
TVP: 118843532(PLCG2)
OAA: 100076776(PLCG2)
GGA: 415805(PLCG2)
PCOC: 116243922(PLCG2)
MGP: 100549684(PLCG2)
CJO: 107319403(PLCG2)
TPAI: 128082052(PLCG2)
LMUT: 125699039(PLCG2)
NMEL: 110404260(PLCG2)
APLA: 101799246(PLCG2)
ACYG: 106044837(PLCG2)
CATA: 118246617(PLCG2)
AFUL: 116494152(PLCG2)
TGU: 100219388(PLCG2)
LSR: 110476350(PLCG2)
SCAN: 103816730(PLCG2)
PMOA: 120508082(PLCG2)
OTC: 121334040(PLCG2)
PRUF: 121348913(PLCG2)
GFR: 102039725(PLCG2)
FAB: 101811465(PLCG2)
OMA: 130257856(PLCG2)
PHI: 102103443(PLCG2)
PMAJ: 107209788(PLCG2)
CCAE: 111934454(PLCG2)
CCW: 104691823(PLCG2)
CBRC: 103620109(PLCG2)
ETL: 114066562(PLCG2)
ZAB: 102064935(PLCG2)
ZLE: 135452876(PLCG2)
ACHL: 103803834
SVG: 106852067(PLCG2)
MMEA: 130577280(PLCG2)
HRT: 120757825(PLCG2)
SATI: 136366473(PLCG2)
FPG: 101914329(PLCG2)
FCH: 102058636(PLCG2)
CCRI: 104164322(PLCG2)
NNT: 104402843(PLCG2)
SHAB: 115619893(PLCG2)
ACUN: 113484485(PLCG2)
TALA: 104357329(PLCG2)
ACHC: 115345998(PLCG2)
HALD: 104325196(PLCG2)
HLE: 104839384(PLCG2)
AGEN: 126040423
GCL: 127021030
CSTI: 104563586(PLCG2)
LDI: 104352535(PLCG2)
MNB: 103772869(PLCG2)
DPUB: 104300823(PLCG2)
AVIT: 104281388(PLCG2)
BRHI: 104496950(PLCG2)
EGZ: 104133768(PLCG2)
NNI: 104014569(PLCG2)
PCRI: 104033730(PLCG2)
PCAO: 104048375(PLCG2)
PADL: 103923865(PLCG2)
AFOR: 103897308(PLCG2)
FGA: 104079549(PLCG2)
GSTE: 104250779(PLCG2)
CLV: 102095823(PLCG2)
MUI: 104543108(PLCG2)
PGUU: 104460935(PLCG2)
PLET: 104617540(PLCG2)
EHS: 104505877(PLCG2)
CMAC: 104486418(PLCG2)
CUCA: 104059381(PLCG2)
TEO: 104381078(PLCG2)
BREG: 104638899(PLCG2)
OHA: 104339197(PLCG2)
ACAR: 104522667(PLCG2)
CPEA: 104396358(PLCG2)
CVF: 104291180(PLCG2)
RTD: 128908577(PLCG2)
AAM: 106483269(PLCG2)
AROW: 112962495(PLCG2)
NPD: 112949908(PLCG2)
TGT: 104567312(PLCG2)
DNE: 112978838(PLCG2)
SCAM: 104149338(PLCG2)
ASN: 102378303(PLCG2)
AMJ: 106736910(PLCG2)
CPOO: 109310651(PLCG2)
GGN: 109289467(PLCG2)
PSS: 102454220(PLCG2)
CMY: 102930635(PLCG2)
CCAY: 125645320(PLCG2)
DCC: 119840995(PLCG2)
CPIC: 101932685(PLCG2)
TST: 117886777(PLCG2)
CABI: 116816699(PLCG2)
MRV: 120384432(PLCG2)
ACS: 100566814(plcg2)
ASAO: 132783040(PLCG2)
PVT: 110085508(PLCG2)
SUND: 121914835(PLCG2)
PBI: 103052396(PLCG2)
PMUR: 107292601(PLCG2)
CTIG: 120312591(PLCG2)
TSR: 106539149(PLCG2)
PGUT: 117670361(PLCG2)
APRI: 131184325(PLCG2)
PTEX: 113445120(PLCG2)
NSS: 113414939(PLCG2)
VKO: 123025316(PLCG2)
PMUA: 114601931(PLCG2)
PRAF: 128419153(PLCG2)
ZVI: 118087873(PLCG2)
HCG: 128334301(PLCG2)
GJA: 107105783(PLCG2)
STOW: 125443848(PLCG2)
EMC: 129343968(PLCG2)
XLA: 108714087(plcg2.L)
XTR: 100496686(plcg2)
NPR: 108786572(PLCG2)
RTEM: 120917948(PLCG2)
BBUF: 120981059(PLCG2)
MUO: 115470901(PLCG2)
GSH: 117359058(PLCG2)
DRE: 561747(plcg2)
SRX: 107722471 107738392
SANH: 107666218 107666222(plcg2) 107684680
SGH: 107559804(plcg2) 107587040 107587041
CCAR: 109047939 109057498
CAUA: 113061559 113061561 113118238
CGIB: 127934627 127977584
PTET: 122362774(plcg2)
LROH: 127181164(plcg2)
OMC: 131524740(plcg2)
PPRM: 120462011(plcg2)
RKG: 130094821(plcg2)
MAMB: 125253968(plcg2)
CIDE: 127500215
CERY: 137023276(plcg2)
MASI: 127417260 127455887
TROS: 130562479(plcg2)
TDW: 130436032
MANU: 129419762(plcg2) 129419763 129419764
IPU: 108264222
IFU: 128606925(plcg2)
PHYP: 113534527(plcg2)
SMEO: 124395716(plcg2)
TFD: 113652640(plcg2)
TVC: 132851365(plcg2)
TRN: 134322873(plcg2)
AMEX: 103036277(plcg2)
CMAO: 118818167(plcg2)
EEE: 113577174(plcg2)
CHAR: 105900725 105904657(plcg2)
TRU: 101072923(plcg2)
TFS: 130536386(plcg2)
TNG: GSTEN00016798G001
LCO: 104932460(plcg2)
TBEN: 117484411(plcg2)
CGOB: 115009314(plcg2)
PGEO: 117450121(plcg2)
GACU: 117553219(plcg2)
EMAC: 134876246(plcg2)
ELY: 117250944 117262733(plcg2)
EFO: 125887137(plcg2)
PLEP: 121949768(plcg2)
SLUC: 116040257(plcg2)
ECRA: 117948801(plcg2)
ESP: 116693373 116693374
PFLV: 114560248(plcg2)
GAT: 120808617(plcg2)
PPUG: 119196016(plcg2)
AFB: 129107826(plcg2)
CLUM: 117731905(plcg2)
PSWI: 130195679(plcg2)
MSAM: 119893498
SCHU: 122874454
CUD: 121514969
ALAT: 119024782(plcg2)
MZE: 101479429(plcg2)
ONL: 100697485(plcg2)
OAU: 116318822(plcg2)
OLA: 101157053(plcg2)
OML: 112152461(plcg2)
CSAI: 133443937(plcg2)
XMA: 102220131(plcg2)
XCO: 114137117(plcg2)
XHE: 116708435(plcg2)
PRET: 103466833(plcg2)
PFOR: 103129264(plcg2)
PLAI: 106936613(plcg2)
PMEI: 106911768(plcg2)
GAF: 122835085(plcg2)
PPRL: 129359838(plcg2)
CVG: 107084318(plcg2)
CTUL: 119789164(plcg2)
GMU: 124860019(plcg2)
NFU: 107389305(plcg2)
KMR: 108237447(plcg2)
ALIM: 106536649(plcg2)
NWH: 119415540(plcg2)
AOCE: 111563111(plcg2)
MCEP: 125015418(plcg2)
CSEM: 103379748(plcg2)
POV: 109641214(plcg2)
HHIP: 117763823(plcg2)
HSP: 118109207(plcg2)
PPLT: 128444206(plcg2)
SMAU: 118315330(plcg2)
LCF: 108902239
SDU: 111229657(plcg2)
SLAL: 111647676(plcg2)
XGL: 120793769
HCQ: 109513068(plcg2)
SSCV: 125970551
SBIA: 133502019(plcg2)
PEE: 133402913(plcg2)
PTAO: 133477573(plcg2)
BPEC: 110169397(plcg2)
MALB: 109967271(plcg2)
BSPL: 114857550 114857551
SJO: 128358370(plcg2)
SASA: 106573684(plcg2)
STRU: 115151896(plcg2)
OTW: 112252303(plcg2)
OMY: 100136053(plcg2)
OGO: 124000074(plcg2)
ONE: 115109334(plcg2)
OKI: 109889294(plcg2)
OKE: 118401316(plcg2)
SALP: 111952198(plcg2)
SNH: 120053864(plcg2)
CCLU: 121576695(plcg2)
ELS: 105018577(plcg2)
SFM: 108926548 108926652(plcg2)
PKI: 111851875(plcg2)
AANG: 118228424(plcg2)
LOC: 102696681(plcg2)
PSPA: 121295981 121296706 121325734
ARUT: 117424336 117424596 117425617
PSEX: 120535553(plcg2)
LCM: 102358132(PLCG2)
CMK: 103175953(plcg2)
RTP: 109928136(plcg2)
CPLA: 122558270(plcg2)
HOC: 132823890(plcg2)
LERI: 129705387(plcg2)
API: 100161327
TCF: 131881317
BGT: 106070801
 » show all
Reference
PMID:2849563
  Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
  Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
  Journal
FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7
  Sequence
[hsa:5336]
Reference
PMID:23555801
  Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
  Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
  Journal
PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842

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