KEGG ORTHOLOGY: K08736

ORTHOLOGY: K08736

Entry

K08736                      KO

Symbol

MSH3

Name

DNA mismatch repair protein MSH3

Pathway

map01524

Platinum drug resistance

map03430

Mismatch repair

map05200

Pathways in cancer

map05210

Colorectal cancer

Disease

H00020

Colorectal cancer

H00026

Endometrial cancer

H01025

Familial adenomatous polyposis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08736  MSH3; DNA mismatch repair protein MSH3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08736  MSH3; DNA mismatch repair protein MSH3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08736  MSH3; DNA mismatch repair protein MSH3
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08736  MSH3; DNA mismatch repair protein MSH3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08736  MSH3; DNA mismatch repair protein MSH3
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08736  MSH3; DNA mismatch repair protein MSH3

Genes

HSA:	4437(MSH3)

PTR:	735384(MSH3)

PPS:	100972976(MSH3)

GGO:	101124461(MSH3)

PON:	100171924(MSH3)

NLE:	100595600(MSH3)

HMH:	116471049(MSH3)

MCC:	711187(MSH3)

MCF:	102136760(MSH3)

MTHB:

126957572

MNI:	105475067(MSH3)

CSAB:

103223859(MSH3)

CATY:

105599143(MSH3)

PANU:

101002001(MSH3)

TGE:	112626187(MSH3)

MLEU:

105550607(MSH3)

RRO:	104680186(MSH3)

RBB:	108528914(MSH3)

TFN:	117064968(MSH3)

PTEH:

111544441(MSH3)

CANG:

105506262(MSH3)

CJC:	100406902(MSH3)

SBQ:	101044317(MSH3)

CIMI:

108288546(MSH3)

CSYR:

103249660(MSH3)

MMUR:

105872639(MSH3)

LCAT:

123648584(MSH3)

PCOQ:

105826621(MSH3)

OGA:	100950391(MSH3)

MMU:	17686(Msh3)

MCAL:

110308223(Msh3)

MPAH:

110328815(Msh3)

RNO:	499505(Msh3)

MCOC:

116083706(Msh3)

ANU:	117700391(Msh3)

MUN:	110546895(Msh3)

CGE:	100762943(Msh3)

MAUA:

101834684(Msh3)

PROB:

127221056(Msh3)

PLEU:

114708052(Msh3)

MORG:

121455740(Msh3)

MFOT:

126508490

AAMP:

119808782(Msh3)

NGI:	103750270(Msh3)

HGL:	101700364(Msh3)

CPOC:

100730041(Msh3)

CCAN:

109688113(Msh3)

DORD:

105985316(Msh3)

DSP:	122117188(Msh3)

PLOP:

125339816(Msh3)

NCAR:

124986782

OCU:

100337807

OPI:	101522303(MSH3)

TUP:	102501896(MSH3)

GVR:	103585604(MSH3)

CFA:	479164(MSH3)

CLUD:

112653293(MSH3)

VVP:	112919583(MSH3)

VLG:	121489321(MSH3)

NPO:	129521059(MSH3)

AML:	100475866(MSH3)

UMR:	103681472(MSH3)

UAH:	113255156(MSH3)

UAR:	123791524(MSH3)

ELK:

111148257

LLV:

125099843

MPUF:

101682495(MSH3)

NVS:	122918073(MSH3)

ORO:	101381286(MSH3)

EJU:	114217627(MSH3)

ZCA:	113929320(MSH3)

MLX:	118016948(MSH3)

NSU:	110589212(MSH3)

LWW:	102737037(MSH3)

FCA:	101090919(MSH3)

PYU:	121013833(MSH3)

PCOO:

112861135(MSH3)

PBG:	122490378(MSH3)

LRUF:

124518549

PTG:	102950877(MSH3)

PPAD:

109274919(MSH3)

PUC:

125935786

AJU:

106972137

HHV:	120222318(MSH3)

BTA:	616744(MSH3)

BOM:	102274795(MSH3)

BIU:	109562288(MSH3)

BBUB:

102415934(MSH3)

BBIS:

105005390(MSH3)

CHX:	102171330(MSH3)

OAS:	101121679(MSH3)

BTAX:

128051137(MSH3)

ODA:	120863313(MSH3)

CCAD:

122440810(MSH3)

SSC:	100512158(MSH3)

CFR:	102505126(MSH3)

CBAI:

105064336(MSH3)

CDK:	105084838(MSH3)

VPC:	102544446(MSH3)

BACU:

103019393(MSH3)

LVE:	103071096 103086628(MSH3)

OOR:	101286492(MSH3)

DLE:	111184789(MSH3)

PCAD:

102978499(MSH3)

PSIU:

116752046(MSH3)

NASI:

112406740(MSH3)

ECB:	100073255(MSH3)

EPZ:	103549605(MSH3)

EAI:	106841188(MSH3)

MYB:	102254819(MSH3)

MYD:	102760014(MSH3)

MMYO:

118656209(MSH3)

MLF:	102421502(MSH3)

MNA:

107543706

PKL:	118702800(MSH3)

HAI:	109388130(MSH3)

DRO:	112307501(MSH3)

SHON:

118977516(MSH3)

AJM:	119059582(MSH3)

PDIC:

114506298(MSH3)

PHAS:

123824742(MSH3)

MMF:	118641388(MSH3)

RFQ:	117025043(MSH3)

PALE:

102878992(MSH3)

PGIG:

120612489(MSH3)

PVP:	105303754(MSH3)

RAY:	107499335(MSH3)

TOD:	119260874(MSH3)

SARA:

101543587(MSH3)

LAV:	100674995(MSH3)

TMU:

101358048

ETF:	101645623(MSH3)

DNM:	101446944(MSH3)

MDO:	100015958(MSH3)

GAS:	123236559(MSH3)

SHR:	100916871(MSH3)

AFZ:

127559152

PCW:	110222556(MSH3)

OAA:	100081413(MSH3)

GGA:	427318(MSH3)

PCOC:

116235325(MSH3)

MGP:	104915285(MSH3)

CJO:	107306538(MSH3)

TPAI:

128089351(MSH3)

NMEL:

110389592(MSH3)

APLA:

101797839(MSH3)

ACYG:

106042720(MSH3)

AFUL:

116500842(MSH3)

TGU:	100220355(MSH3)

LSR:	110482513(MSH3)

SCAN:

103823071(MSH3)

PMOA:

120496170(MSH3)

OTC:	121347776(MSH3)

PRUF:

121351308(MSH3)

GFR:	102037792(MSH3)

FAB:	101811685(MSH3)

PHI:	102113143(MSH3)

PMAJ:

107215881(MSH3)

CCAE:

111941610(MSH3)

CCW:	104695831(MSH3)

CBRC:

103618988(MSH3)

ETL:	114056083(MSH3)

ZAB:	102063217(MSH3)

SVG:	106861523(MSH3)

FPG:	101913150(MSH3)

FCH:	102047877(MSH3)

CLV:	102092981(MSH3)

EGZ:	104128349(MSH3)

NNI:	104022997(MSH3)

ACUN:

113490261(MSH3)

TALA:

104368244(MSH3)

PADL:

103923435(MSH3)

AFOR:

103900357(MSH3)

ACHC:

115336824(MSH3)

HALD:

104318683(MSH3)

HLE:	104838379(MSH3)

AGEN:

126035958

GCL:

127027615

CCRI:

104159843(MSH3)

CSTI:

104557272

FGA:	104077448(MSH3)

LDI:	104351875(MSH3)

MNB:

103772756

OHA:

104329751

SHAB:

115600861(MSH3)

DPUB:

104309373(MSH3)

ACAR:

104529973(MSH3)

CPEA:

104398317(MSH3)

CVF:	104288132(MSH3)

CUCA:

104058743(MSH3)

TEO:	104377028(MSH3)

BRHI:

104500749(MSH3)

AROW:

112974631(MSH3)

NPD:	112943991(MSH3)

TGT:	104574299(MSH3)

DNE:	112983664(MSH3)

SCAM:

104152910(MSH3)

ASN:	102387295(MSH3)

AMJ:	102563518(MSH3)

CPOO:

109308068(MSH3)

GGN:	109297279(MSH3)

PSS:	102450560(MSH3)

CMY:	102941347(MSH3)

CPIC:

101935055(MSH3)

TST:	117879133(MSH3)

CABI:

116832874(MSH3)

MRV:	120408324(MSH3)

ACS:	100554606(msh3)

PVT:	110077322(MSH3)

SUND:

121921079(MSH3)

PBI:	103064642(MSH3)

PMUR:

107299642(MSH3)

CTIG:

120297775(MSH3)

TSR:	106538764(MSH3)

PGUT:

117679342(MSH3)

PTEX:

113448021(MSH3)

NSS:	113414837(MSH3)

VKO:	123031482(MSH3)

PMUA:

114606377(MSH3)

ZVI:	118076767(MSH3)

HCG:	128342969(MSH3)

GJA:	107124616(MSH3)

STOW:

125436976(MSH3)

XLA:	108717641(msh3.L)

XTR:	100486354(msh3)

NPR:	108794203(MSH3)

RTEM:

120930422(MSH3)

BBUF:

120992486(MSH3)

BGAR:

122924687(MSH3)

DRE:	565400(msh3)

SRX:

107720281

SANH:

107699681(msh3)

SGH:	107587513(msh3)

CAUA:

113049619(msh3)

CGIB:

127958212

PTET:

122346019(msh3)

LROH:

127164802(msh3)

PPRM:

120472322(msh3)

MAMB:

125267516(msh3)

CIDE:

127513323

MASI:

127436459

IPU:

108255996

PHYP:

113537202(msh3)

SMEO:

124380852(msh3)

TFD:	113637639(msh3)

AMEX:

103037699(msh3)

CMAO:

118827544(msh3)

EEE:	113574961(msh3)

TRU:	101078721(msh3)

TNG:	GSTEN00028603G001

LCO:	104930140(msh3)

CGOB:

115012929(msh3)

ELY:	117251988(msh3)

EFO:	125890594(msh3)

PLEP:

121944527(msh3)

SLUC:

116054056(msh3)

ECRA:

117945139(msh3)

ESP:	116690102(msh3)

PFLV:

114556204(msh3)

GAT:	120831076(msh3)

PPUG:

119224536(msh3)

MSAM:

119891635(msh3)

SCHU:

122876260(msh3)

CUD:	121510243(msh3)

ALAT:

119019527(msh3)

MZE:	101481912(msh3)

ONL:

100695943

OAU:	116328384(msh3)

OLA:	101156254(msh3)

OML:	112148829(msh3)

XMA:

102235782

XCO:	114154114(msh3)

XHE:	116730404(msh3)

PRET:

103470074(msh3)

PFOR:

103132313 103141740

PLAI:

106938555 106938834(msh3)

PMEI:

106908704 106911961

GAF:	122826867(msh3)

CVG:	107094525(msh3)

CTUL:

119798590(msh3)

GMU:	124877721(msh3)

NFU:	107394171(msh3)

KMR:	108233536(msh3)

ALIM:

106513654(msh3)

NWH:	119413259(msh3)

AOCE:

111564701(msh3)

MCEP:

125012899(msh3)

CSEM:

103397624(msh3)

POV:	109636975(msh3)

SSEN:

122769750(msh3)

HHIP:

117768007(msh3)

HSP:	118115207(msh3)

LCF:

108881996

SDU:	111237718(msh3)

SLAL:

111661018(msh3)

XGL:	120805552(msh3)

HCQ:	109527053(msh3)

SSCV:

125993855

BPEC:

110175640(msh3)

MALB:

109956610(msh3)

BSPL:

114862247(msh3)

STRU:

115164092(msh3)

OTW:	112249542(msh3)

OMY:	110526050(msh3)

OGO:	124034012(msh3)

ONE:	115111945(msh3)

SALP:

111974598(msh3)

SNH:	120044139(msh3)

CCLU:

121584566(msh3)

ELS:	105007963(msh3)

SFM:	108939000(msh3)

PKI:	111850310(msh3)

AANG:

118206656(msh3)

LOC:	102685642(msh3)

PSPA:

121303907 121306412(msh3)

ARUT:

117403778 117404116

PSEX:

120532843(msh3)

LCM:	102354624(MSH3)

CMK:	103182681(msh3)

RTP:

109919699

CPLA:

122559042(msh3)

BFO:

BBEL:

SPU:

APLC:

AJC:

SKO:

FOC:

TPAL:

ZNE:

CSEC:

DPX:	DAPPUDRAFT_327819 DAPPUDRAFT_336969

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:	126982841 126996094

LSM:

121127831

ISC:	IscW_ISCW004103

DSV:

RSAN:

RMP:

PTEP:

SDM:

LPOL:

LGI:	LOTGIDRAFT_208479

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:	106156157 106158626

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

HMG:

ATH:	AT4G25540(MSH3)

ALY:

9305740

CRB:

17878284

CSAT:

104717707 104722413 104730875

EUS:	EUTSA_v10024274mg

BRP:

103861568

BNA:	106407650 106440848

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10004302mg

PVY:

MINC:

TCC:

GRA:

GHI:	107936854 107947306

GAB:

108480022

DZI:

111289365

EGR:	104424409 104430076

GMX:

100789883

GSJ:

114403787

PVU:	PHAVU_007G069100g

VRA:

VAR:

VUN:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

LJA:	Lj5g3v2013910.1(Lj5g3v2013910.1)

ADU:

107467000

AIP:

107618836

AHF:	112711658 112775261

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

QSU:

QLO:

TWL:

VVI:

VRI:	117933068 117933724

SLY:

SPEN:

SOT:

SSTN:

CANN:

NTA:	107762128 107801185

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

BVG:

SOE:

CQI:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os04t0682900-01(Os04g0682900)

OBR:

OGL:

BDI:

ATS:

TDC:	119357990 119360998 119360999

TAES:

123045913 123055834 123185675 542976

TUA:	125537332 125538873

LPER:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121967423 122052644

DCT:

PEQ:

AOF:

NCOL:

ATR:

SMO:	SELMODRAFT_114371 SELMODRAFT_136810 SELMODRAFT_20623 SELMODRAFT_30474 SELMODRAFT_420792 SELMODRAFT_420794 SELMODRAFT_420798

PPP:

112275975

MNG:	MNEG_14639

CSL:	COCSUDRAFT_64608

CVR:	CHLNCDRAFT_134093

APRO:

F751_0287

OLU:	OSTLU_49314

OTA:	OT_ostta04g02050

BPG:	Bathy06g04210

MIS:	MICPUN_58155(MSH3)

MPP:	MICPUCDRAFT_56979(MSH3)

CCP:	CHC_T00001698001

SCE:	YCR092C(MSH3)

SEUB:

DI49_0834

SPAO:

SPAR_C01360

AGO:	AGOS_ADR168C

ERC:

Ecym_6039

KLA:	KLLA0_C18590g

KMX:	KLMA_40023(MSH3)

LTH:	KLTH0A07480g

VPO:	Kpol_183p2

ZRO:	ZYRO0D17490g

CGR:	CAGL0E00473g

NCS:	NCAS_0D04700(NCAS0D04700)

NDI:	NDAI_0I00260(NDAI0I00260)

TPF:	TPHA_0H02400(TPHA0H02400)

TBL:	TBLA_0F00230(TBLA0F00230)

TGB:	HG536_0A09460

TDL:	TDEL_0A07870(TDEL0A07870)

KAF:	KAFR_0J02610(KAFR0J02610)

KNG:	KNAG_0I02660(KNAG0I02660)

ZMK:	HG535_0F00250

PPA:	PAS_chr1-4_0376

DHA:	DEHA2B13574g

PIC:	PICST_59113

PGU:	PGUG_01807

SPAA:

SPAPADRAFT_70807

LEL:	LELG_02545

CAL:	CAALFM_C208680WA(MSH3)

CTP:	CTRG_01949

COT:	CORT_0C02620

CDU:	CD36_22850

CTEN:

CANTEDRAFT_126075

YLI:	YALI0A09724g

CLU:	CLUG_05299

CLUS:

A9F13_14g00715

CAUR:

CJI96_0004362

SLB:	AWJ20_5128(MSH3)

PKZ:	C5L36_0C07420

BNN:	FOA43_003883

BBRX:

BRETT_000600

OPA:	HPODL_04591

SLUD:

SCDLUD_003773

NCR:	NCU08115(msh3)

NTE:	NEUTE1DRAFT88806(NEUTE1DRAFT_88806)

SMP:	SMAC_08039(putative_msh3)

PAN:	PODANSg5575

TTT:	THITE_2114009

MTM:	MYCTH_2295777

CTHR:

CTHT_0057300

MGR:

MGG_09306

PPEI:

PpBr36_07645

TMN:	UCRPA7_8052

SSCK:

SPSK_00073

FGR:	FGSG_07112

FPU:	FPSE_02669

FVR:	FVEG_08056

FOX:	FOXG_01691

NHE:	NECHADRAFT_39064

TRE:	TRIREDRAFT_3208

TRR:	M419DRAFT_128413

MAW:

MAC_01069

MAJ:

MAA_05665

CMT:

CCM_05581

PLJ:	VFPFJ_05306

PTKZ:

JDV02_001167(MSH3)

VAL:	VDBG_04688

VDA:	VDAG_04229

CFJ:	CFIO01_04965

CLUP:

CLUP02_05233

CHIG:

CH63R_00408

SAPO:

SAPIO_CDS0750

ELA:	UCREL1_8915

PFY:	PFICI_01017

SSL:	SS1G_02907

BFU:	BCIN_06g05300(Bcmsh3)

MBE:

MBM_04892

PSCO:

LY89DRAFT_636859

GLZ:	GLAREA_04929

ANI:

AN3749.2

AFM:	AFUA_7G04480

ACT:	ACLA_006180

NFI:	NFIA_025450

AOR:	AO090005000134

ANG:	ANI_1_150114(An13g01060)

AFV:	AFLA_002917

ALUC:

AKAW2_20105A(MSH3)

ACHE:

ACHE_40174A(MSH3)

APUU:

APUU_40714A(MSH3)

PCS:	Pc21g08840

PDP:	PDIP_58340

TMF:	EYB26_004890

TRG:	TRUGW13939_01703

CIM:	CIMG_07540

CPW:	CPC735_043880

URE:	UREG_07739

PBL:	PAAG_09097

PBN:	PADG_08606

ABE:

ARB_02429

TVE:

TRV_03218

AJE:	HCAG_06362

BGH:	BDBG_09053

PNO:	SNOG_03496(SNOG_03495)

PTE:

PTT_17141

BZE:	COCCADRAFT_87085

BSC:	COCSADRAFT_147401

BOR:	COCMIDRAFT_7439

AALT:

CC77DRAFT_934586

ZTR:	MYCGRDRAFT_45599

PFJ:	MYCFIDRAFT_204401

FFU:	CLAFUR5_12366

BCOM:

BAUCODRAFT_39478

NPA:	UCRNP2_3939

TML:	GSTUM_00011039001

SPO:	SPAC8F11.03(msh3)

CNE:

CNC01550

CNB:

CNBC5700

CNG:	CNAG_01642

CGI:	CGB_C2370C

TMS:	TREMEDRAFT_74736

TASA:

A1Q1_02991

PPL:	POSPLDRAFT_95699

TVS:	TRAVEDRAFT_57899

PCO:	PHACADRAFT_96015

SHS:	STEHIDRAFT_145410

HIR:	HETIRDRAFT_44359

PSQ:	PUNSTDRAFT_121053

ADL:	AURDEDRAFT_87246

FME:	FOMMEDRAFT_104344

GTR:	GLOTRDRAFT_137270

CCI:	CC1G_03897

ABP:	AGABI1DRAFT34226(AGABI1DRAFT_34226)

ABV:	AGABI2DRAFT141320(AGABI2DRAFT_141320)

MRR:	Moror_6482

E1B28_008738

SCM:	SCHCO_02483197(SCHCODRAFT_02483197)

CPUT:

CONPUDRAFT_69938

SLA:	SERLADRAFT_441366

UMA:	UMAG_04275

PFP:	PFL1_03304

MGL:

MGL_3423

MRT:

MRET_1458

MSYM:

MSY001_1625

PGR:	PGTG_02803

MBR:	MONBRDRAFT_22782

SRE:	PTSG_12896

DDI:	DDB_G0281683(msh3)

DPP:	DICPUDRAFT_52102

DFA:	DFA_00628(msh3)

ACAN:

ACA1_128040

PIF:	PITG_11296

PSOJ:

PHYSODRAFT_311440

TBR:	Tb09.160.3760

TBG:	TbgDal_IX2780

TCR:	508277.180

LMA:	LMJF_15_1420

LIF:	LINJ_15_1470

LDO:	LDBPK_151470

LMI:	LMXM_15_1420

LBZ:	LBRM_15_1420

LPAN:

LPMP_151370

» show all

Reference

PMID:7926796

Authors

Liu K, Niu L, Linton JP, Crouse GF

Title

Characterization of the mouse Rep-3 gene: sequence similarities to bacterial and yeast mismatch-repair proteins.

Journal

Gene 147:169-77 (1994)
DOI:10.1016/0378-1119(94)90062-0

Sequence

[mmu:17686]

Reference

PMID:17157869

Authors

Lee SD, Surtees JA, Alani E

Title

Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.

Journal

J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099

Sequence

[sce:YCR092C]

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Gene (1520)   
   KEGG GENES (698)   
   KEGG MGENES (344)   
   RefGene (468)   
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Literature (2)   
   PubMed (2)   
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