KEGG   DRUG: Enfortumab vedotin
Entry
D11525                      Drug                                   
Name
Enfortumab vedotin (USAN);
Enfortumab vedotin (genetical recombination) (JAN);
Enfortumab vedotin-ejfv;
Padcev (TN)
Product
PADCEV (SEAGEN)
Formula
C6642H10284N1742O2063S46
Exact mass
148930.0517
Mol weight
149022.148
Remark
Therapeutic category: 4291
ATC code: L01FX13
Product: D11525<JP/US>
Efficacy
Antineoplastic, Nectin-4 antibody, Tubulin polymerization inhibitor
  Disease
Urothelial cancer [DS:H00022]
  Type
Antibody-drug conjugate
Comment
Treatment of cancers expressing Nectin-4
Target
PVRL4 (NECTIN4) [HSA:81607] [KO:K06593]
TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375]
  Pathway
hsa04145  Phagosome
hsa04520  Adherens junction
hsa04540  Gap junction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX13 Enfortumab vedotin
      D11525  Enfortumab vedotin (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Enfortumab Vedotin
    D11525  Enfortumab vedotin (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11525  Enfortumab vedotin (USAN); Enfortumab vedotin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Other
    PVRL4 (NECTIN4)
     D11525  Enfortumab vedotin (USAN) <JP/US>
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D11525  Enfortumab vedotin (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11525
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11525
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11525
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11525
Other DBs
CAS: 1346452-25-2
PubChem: 384585501

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Ontology (8)   
   KEGG BRITE (8)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (12)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (10)   
All databases (22)   

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