KEGG   ENZYME: 1.14.99.52Help
Entry
EC 1.14.99.52               Enzyme                                 

Name
L-cysteinyl-L-histidinylsulfoxide synthase;
OvoA
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
L-histidine,L-cysteine:oxygen [S-(L-histidin-5-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
L-histidine + L-cysteine + O2 = S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O [RN:R11015]
Reaction(KEGG)
Substrate
L-histidine [CPD:C00135];
L-cysteine [CPD:C00097];
O2 [CPD:C00007]
Product
S-(L-histidin-5-yl)-L-cysteine S-oxide [CPD:C20993];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC 1.13.11.20, cysteine dioxygenase, and can perform the reaction of EC 1.14.99.50, gamma-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4].
History
EC 1.14.99.52 created 2015
Reference
1  [PMID:21247153]
  Authors
Braunshausen A, Seebeck FP
  Title
Identification and characterization of the first ovothiol biosynthetic enzyme.
  Journal
J Am Chem Soc 133:1757-9 (2011)
DOI:10.1021/ja109378e
Reference
2  [PMID:24016264]
  Authors
Song H, Leninger M, Lee N, Liu P
  Title
Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses.
  Journal
Org Lett 15:4854-7 (2013)
DOI:10.1021/ol402275t
Reference
3  [PMID:23877651]
  Authors
Mashabela GT, Seebeck FP
  Title
Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis.
  Journal
Chem Commun (Camb) 49:7714-6 (2013)
DOI:10.1039/c3cc42594k
Reference
4  [PMID:24684381]
  Authors
Song H, Her AS, Raso F, Zhen Z, Huo Y, Liu P
  Title
Cysteine oxidation reactions catalyzed by a mononuclear non-heme iron enzyme (OvoA) in ovothiol biosynthesis.
  Journal
Org Lett 16:2122-5 (2014)
DOI:10.1021/ol5005438
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.52
IUBMB Enzyme Nomenclature: 1.14.99.52
ExPASy - ENZYME nomenclature database: 1.14.99.52
BRENDA, the Enzyme Database: 1.14.99.52

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