KEGG   ENZYME: 1.3.8.1Help
Entry
EC 1.3.8.1                  Enzyme                                 

Name
short-chain acyl-CoA dehydrogenase;
butyryl-CoA dehydrogenase;
butanoyl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADS (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R01178]
Reaction(KEGG)
Substrate
short-chain acyl-CoA [CPD:C20675];
electron-transfer flavoprotein [CPD:C04253]
Product
short-chain trans-2,3-dehydroacyl-CoA [CPD:C20676];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.1 created 1961 as EC 1.3.2.1, transferred 1964 to EC 1.3.99.2, transferred 2011 to EC 1.3.8.1, modified 2012
Pathway
ec00071  Fatty acid degradation
ec00280  Valine, leucine and isoleucine degradation
ec00410  beta-Alanine metabolism
ec00640  Propanoate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00248  butyryl-CoA dehydrogenase
Genes
HSA: 35(ACADS)
PTR: 742921(ACADS)
PPS: 100994372(ACADS)
GGO: 101139640(ACADS)
PON: 100172331(ACADS)
NLE: 100586242(ACADS)
MCC: 698196(ACADS)
MCF: 102116240(ACADS)
CSAB: 103239266(ACADS)
RRO: 104666263(ACADS)
RBB: 108529647(ACADS)
CJC: 100387870(ACADS)
SBQ: 101049174(ACADS)
MMU: 11409(Acads)
MCAL: 110294359(Acads)
MPAH: 110312894(Acads)
RNO: 64304(Acads)
MUN: 110545603(Acads)
CGE: 100774097(Acads)
NGI: 103740119(Acads)
HGL: 101722158(Acads)
CCAN: 109696148(Acads)
OCU: 100352290(ACADS)
TUP: 102494372(ACADS)
CFA: 477517(ACADS)
VVP: 112932920(ACADS)
AML: 100483719(ACADS)
UMR: 103678351(ACADS)
UAH: 113267053(ACADS)
ORO: 101363887(ACADS)
ELK: 111156416
FCA: 101082442(ACADS)
PTG: 102956610(ACADS)
PPAD: 109277518(ACADS)
AJU: 106971681(ACADS)
BTA: 511222(ACADS)
BOM: 102269247(ACADS)
BIU: 109571341(ACADS)
BBUB: 102390388(ACADS)
CHX: 102180069(ACADS)
OAS: 101119850(ACADS)
SSC: 396932(ACADS)
CFR: 102503720(ACADS)
CDK: 105101985(ACADS)
BACU: 103010876(ACADS)
LVE: 103083994(ACADS)
OOR: 101278842(ACADS)
DLE: 111162645(ACADS)
PCAD: 102993784(ACADS)
ECB: 100147113(ACADS)
EPZ: 103540479(ACADS)
EAI: 106844801(ACADS)
MYB: 102250514(ACADS)
MYD: 102760180(ACADS)
MNA: 107528464(ACADS)
HAI: 109386149(ACADS)
DRO: 112310812(ACADS)
PALE: 102891595(ACADS)
RAY: 107501257(ACADS)
MJV: 108397688(ACADS)
LAV: 100669421(ACADS)
TMU: 101356048
MDO: 100025804(ACADS)
SHR: 100917746(ACADS)
PCW: 110222822(ACADS)
OAA: 100090404(ACADS)
GGA: 416969(ACADS)
MGP: 100541626(ACADS)
CJO: 107321246(ACADS)
NMEL: 110406474(ACADS)
APLA: 101801937(ACADS)
ACYG: 106031343(ACADS)
TGU: 100232428(ACADS)
LSR: 110481348(ACADS)
SCAN: 103818033(ACADS)
GFR: 102031606(ACADS)
FAB: 101818866(ACADS)
PHI: 102112248(ACADS)
PMAJ: 107211533(ACADS)
CCAE: 111936603(ACADS)
CCW: 104688759(ACADS)
ETL: 114056627(ACADS)
FPG: 101913588(ACADS)
FCH: 102052397(ACADS)
CLV: 102088733(ACADS)
EGZ: 104129891(ACADS)
NNI: 104011497(ACADS)
ACUN: 113486201(ACADS)
PADL: 103922688(ACADS)
AAM: 106486315(ACADS)
ASN: 102368188(ACADS)
AMJ: 102559145(ACADS)
PSS: 102460079(ACADS)
CMY: 102946552(ACADS)
CPIC: 101934662(ACADS)
ACS: 100557906(acads)
PVT: 110081950(ACADS)
PBI: 103059584(ACADS)
PMUR: 107293846(ACADS)
TSR: 106547997(ACADS)
PMUA: 114586642(ACADS)
GJA: 107126092(ACADS)
XLA: 380563(acads.L)
XTR: 394882(acads)
NPR: 108787757(ACADS)
DRE: 445288(acads)
SRX: 107741687
SANH: 107689539
SGH: 107567748
IPU: 100305084(acads)
PHYP: 113544911(acads)
AMEX: 111190888(acads)
EEE: 113583217(acads)
TRU: 101071269(acads)
LCO: 104937354(acads)
NCC: 104954167(acads)
MZE: 101477731(acads)
ONL: 100699540(acads)
OLA: 101166811(acads)
XMA: 102223580(acads)
XCO: 114149491(acads)
PRET: 103473179(acads)
CVG: 107101400(acads)
NFU: 107394661(acads)
KMR: 108244766(acads)
ALIM: 106526092(acads)
AOCE: 111566122(acads)
CSEM: 103389931(acads)
POV: 109626371(acads)
LCF: 108895632(acads)
SDU: 111224280(acads)
SLAL: 111664707(acads)
HCQ: 109525105(acads)
BPEC: 110166693(acads)
MALB: 109974764(acads)
OTW: 112220230
SALP: 112070846
ELS: 105015217
SFM: 108930016(acads)
PKI: 111851473(acads)
LCM: 102355418(ACADS)
CMK: 103182182(acads)
CIN: 100175610
SPU: 579817
APLC: 110980734
SKO: 100372351
DME: Dmel_CG4703(Arc42) Dmel_CG4860(CG4860)
DSI: Dsimw501_GD19319(Dsim_GD19319) Dsimw501_GD20592(Dsim_GD20592)
DPO: Dpse_GA18369(Dpse_Arc42) Dpse_GA18485
LCQ: 111681801
AALB: 115271087
AME: 411697
BIM: 100741796
BTER: 100644786
CCAL: 108624442
OBB: 114870942
SOC: 105194539
MPHA: 105830289
AEC: 105153957
ACEP: 105618056
PBAR: 105433071
VEM: 105559563
HST: 105189744
DQU: 106741964
CFO: 105248503
LHU: 105677833
PGC: 109856861
OBO: 105283842
PCF: 106793225
NVI: 100123507(Acads)
MDL: 103571272
DPA: 109544050
ATD: 109606027
NVL: 108564815
BMOR: 101743734
BMAN: 114247767
PMAC: 106711086
PRAP: 110991435
HAW: 110370948
TNL: 113503041
PXY: 105386881
DNX: 107167049
RMD: 113551422
BTAB: 109039783
CLEC: 106665378
ZNE: 110829314
FCD: 110852939
PVM: 113829792
CSCU: 111616279
PTEP: 107450516
PCAN: 112561493
CRG: 105344312
MYI: 110462869
OBI: 106874336
LAK: 106156920
ADF: 107340803
AMIL: 114968570
PDAM: 113665142
SPIS: 111326119
DGT: 114523525
PTI: PHATR_25932(ACD1)
FCY: FRACYDRAFT_209569(ACD1)
TPS: THAPS_35710(ACD1)
SPAR: SPRG_09395
PAE: PA2552
PAEV: N297_2625
PAEI: N296_2625
PAU: PA14_31540(acdA)
PNC: NCGM2_3560(acdA)
PAEB: NCGM1900_3970(acdA)
PAEP: PA1S_12875
PAEM: U769_12455
PAEL: T223_14075
PAEG: AI22_21045
PAEC: M802_2622
PAEO: M801_2490
PMY: Pmen_2037
PMK: MDS_2682
PCQ: PcP3B5_30330(mmgC_10)
PPU: PP_2216(acd)
PPF: Pput_3522
PPT: PPS_1828
PPI: YSA_01351
PPX: T1E_0547(mmgC)
PPUH: B479_09030
PPUT: L483_08880
PPUN: PP4_35990
PPUD: DW66_2076
PMON: X969_06975
PMOT: X970_06950
PFL: PFL_3065(acdA_2)
PPRC: PFLCHA0_c30930(mmgC6)
PPRO: PPC_3093
PFS: PFLU_3029
PFC: PflA506_2696(acdA)
PFB: VO64_0262
PMAN: OU5_0532
PEN: PSEEN3546(fadFx)
PSA: PST_1917
PSTT: CH92_10735
PKC: PKB_3132(mmgC)
PSEM: TO66_14975
PSEC: CCOS191_1701(mmgC1)
PSOS: POS17_3070
PANR: A7J50_2976
PSET: THL1_3166
PSIL: PMA3_14830
ACB: A1S_0105
ABM: ABSDF0124
ABY: ABAYE3765
ABN: AB57_0147
ABB: ABBFA_03382(mmgC_14)
ABX: ABK1_0138
ABH: M3Q_338
ABAD: ABD1_01060
ABAZ: P795_16625
ABAU: IX87_15110
ABAA: IX88_02830
ACC: BDGL_003032(mmgC)
AGU: AS4_21920
GPS: C427_1949
LPF: lpl0900
LPP: lpp0931
KKO: Kkor_1059
KGE: TQ33_1249
RSO: RSc0274
RSE: F504_292
RSY: RSUY_30080(mmgC_3)
RPI: Rpic_0124
REH: H16_A0172(h16_A0172) H16_B0752(h16_B0752) H16_B0850(h16_B0850)
CNC: CNE_1c01630(bcd1)
RME: Rmet_0108
CGD: CR3_0081
BXE: Bxe_A4257
BXB: DR64_1934
BPH: Bphy_0176
BFN: OI25_1240
AXY: AXYL_03469(acdC2)
RFR: Rfer_3838
POL: Bpro_4185
PNA: Pnap_0459
AAV: Aave_4365
AJS: Ajs_3774
AAA: Acav_4262
ACRA: BSY15_894
DAC: Daci_5985
VPD: VAPA_1c48910(acdA1)
CTES: O987_02655
RTA: Rta_05720
LIM: L103DPR2_00029(mmgC_2)
LIH: L63ED372_03172(mmgC_10)
HYB: Q5W_00095
HPSE: HPF_21120(acdA8)
CBAA: SRAA_1817
CBAB: SMCB_1783
JAG: GJA_42
LCH: Lcho_4207
TIN: Tint_2729
THI: THI_3277(bcd)
RGE: RGE_21120
EBA: ebA3640
DSU: Dsui_0977
DAR: Daro_0096
AZO: azo0394(fadfX)
AZA: AZKH_0513
AOA: dqs_0405
GME: Gmet_1715
GUR: Gura_3040
GBM: Gbem_2832
GEO: Geob_2186
GEM: GM21_1381
GEB: GM18_1288
DEU: DBW_0048(acdA_1)
ADE: Adeh_1665
SCL: sce1166
BMX: BMS_2770(bcd)
ATU: Atu3474(mmgC)
ATF: Ach5_33330(mmgC)
RLE: pRL100302
RLG: Rleg_6504
RIR: BN877_II0490(mmgC)
RHL: LPU83_pLPU83d0282(mmgC)
SHZ: shn_32705
BME: BMEII0818
BMEL: DK63_2428
BMEE: DK62_2978
BMF: BAB2_0791
BABO: DK55_2750
BABR: DO74_3167
BABT: DK49_2487
BABB: DK48_3047
BABU: DK53_2753
BABS: DK51_2237
BABC: DO78_2302
BMS: BRA0447
BSZ: DK67_2454
BOV: BOV_A0391
BCS: BCAN_B0449(acdA)
BCAR: DK60_2173
BCAS: DA85_12635
BMR: BMI_II444
BPP: BPI_II429
BPV: DK65_3172
OAN: Oant_3106
OAH: DR92_3397
RPA: RPA2305
RPD: RPD_3106
RPT: Rpal_2548
XAU: Xaut_4666
MEX: Mext_4104
MET: M446_3936
MNO: Mnod_3635
MAQU: Maq22A_1p34045(caiA)
RVA: Rvan_3409
BVR: BVIR_370
BLAG: BLTE_26970(mmgC_3)
PDE: Pden_2906
RSU: NHU_04473
SHUM: STHU_08880(mmgC)
MAG: amb3599
MGRY: MSR1_20060(mmgC_4)
MAGX: XM1_1678(mmgC)
MAGN: WV31_16400
TMO: TMO_2577(mmgC)
TXI: TH3_18520
HTL: HPTL_0269
BLI: BL03928(acdA)
BLD: BLi03965(acdA)
BLH: BaLi_c39810(acdA)
BHA: BH3798(acdA)
BAN: BA_5586
BAR: GBAA_5586
BAT: BAS5190
BAI: BAA_5611
BANT: A16_55950
BANR: A16R_56630
BANS: BAPAT_5355
BANV: DJ46_4235
BCE: BC5341
BCA: BCE_5472
BCQ: BCQ_5182
BCX: BCA_5491
BNC: BCN_5271
BCF: bcf_26815
BCER: BCK_08645
BTL: BALH_4840(acdA)
BTT: HD73_5748
BTHI: BTK_28280
BTM: MC28_4577(acdA)
BTG: BTB_c55430(acdA)
BTI: BTG_21675
BTW: BF38_1068
BWW: bwei_4436(acdA2)
BMYO: BG05_661
BMYC: DJ92_2435
BPF: BpOF4_07045(acdA)
BAG: Bcoa_1422
BCOA: BF29_2093
BMET: BMMGA3_16165(acdA)
BACO: OXB_1403
BGY: BGLY_4370(acdA)
BBEV: BBEV_0153(acdA)
OIH: OB1695 OB3010(acdA)
GKA: GK3393
GTN: GTNG_3338
GGH: GHH_c34890(acdA)
GEA: GARCT_03377(acdA_3)
AFL: Aflv_2736(acdA)
AAMY: GFC30_334
LSP: Bsph_0974
HLI: HLI_14295
VPN: A21D_00965(acdA_1)
PSYO: PB01_03265
BSE: Bsel_3188
BBE: BBR47_54960(acdA)
ASOC: CB4_00556(acdA_2)
BTS: Btus_3274
SIV: SSIL_3404
JEO: JMA_30560
LBH: Lbuc_0346
CRN: CAR_c21860(acdA)
CAC: CA_C2711(bcd)
CAE: SMB_G2746(bcd)
CAY: CEA_G2719(bcd)
CPF: CPF_0092 CPF_2584(bcd)
CPR: CPR_2286(bcd)
CBO: CBO3199(bcd)
CBA: CLB_3235(bcd)
CBH: CLC_3109(bcd)
CBY: CLM_3611(bcd)
CBL: CLK_2597(bcd)
CBB: CLD_1332(bcd)
CBI: CLJ_B3471(bcd)
CBF: CLI_3338(bcd)
CBM: CBF_3330(bcd)
CBEI: LF65_00356
CKL: CKL_0455(bcd)
CKR: CKR_0400
CSR: Cspa_c04340(bcd1) Cspa_c20900(bcd3)
CPAS: Clopa_1420
CPAT: CLPA_c11000(bcd2) CLPA_c28620(bcd3)
CPAE: CPAST_c11000(bcd2) CPAST_c28620(bcd3)
CSB: CLSA_c03570(bcd1) CLSA_c40890(bcd4)
CLT: CM240_1171(bcd)
CBV: U729_1464
CLD: CLSPO_c33020(bcd3)
CTYK: CTK_C26360(bcd1) CTK_C28050(bcd4)
AMT: Amet_3091
FPR: FP2_20570
FPA: FPR_29610
BPB: bpr_I2485(bcd)
BFI: CIY_01180
BHU: bhn_I2223
RIX: RO1_16590
RIM: ROI_30670
CSO: CLS_36820
CPRO: CPRO_28180(acdA_2)
EHL: EHLA_0977
ERT: EUR_03530
ERA: ERE_22560
CDF: CD630_10540(bcd2)
PDC: CDIF630_01194(bcd)
CDC: CD196_0931(bcd2)
CDL: CDR20291_0910(bcd2)
PDF: CD630DERM_10540(bcd2)
SALQ: SYNTR_0061
DSY: DSY1716
DRM: Dred_1782
DAE: Dtox_1697
HMO: HM1_0900
OVA: OBV_03770(acdA) OBV_16240(acdA)
CTHM: CFE_1422
BPRM: CL3_07570
BPRS: CK3_18870
TTE: TTE0545(CaiA)
CHY: CHY_1350(bcd2)
TTM: Tthe_1660
APR: Apre_1356
PED: ING2D1G_1009(bcd1) ING2D1G_1407(bcd5)
MED: MELS_2128
PUF: UFO1_3313
AIN: Acin_0720
EUC: EC1_11820
AARG: Aargi30884_03080(bcd2)
ABSI: A9CBEGH2_04180(bcd2)
TTH: TT_C0238
TTJ: TTHB022
BHY: BHWA1_01911(acaD)
BRM: Bmur_1546
BPO: BP951000_1040(acaD)
BPW: WESB_2382
BIP: Bint_2792(acaD)
ACA: ACP_2397
PGI: PG_1076(acdA)
PGN: PGN_1172
PGT: PGTDC60_1132(acdA)
TFO: BFO_1489(bcd)
BACC: BRDCF_p446(bcd)
MBAS: ALGA_2264
TLE: Tlet_1831
TME: Tmel_0656
TAF: THA_730
FNO: Fnod_0585
CEX: CSE_15010
 » show all
Taxonomy
Reference
1  [PMID:13130522]
  Authors
MAHLER HR.
  Title
Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase.
  Journal
J Biol Chem 206:13-26 (1954)
Reference
2  [PMID:13130521]
  Authors
GREEN DE, MII S, MAHLER HR, BOCK RM
  Title
Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase.
  Journal
J Biol Chem 206:1-12 (1954)
Reference
3
  Authors
Beinert, H.
  Title
Acyl coenzyme A dehydrogenase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466.
Reference
4  [PMID:6712627]
  Authors
Shaw L, Engel PC
  Title
The purification and properties of ox liver short-chain acyl-CoA dehydrogenase.
  Journal
Biochem J 218:511-20 (1984)
DOI:10.1042/bj2180511
Reference
5  [PMID:7601336]
  Authors
Thorpe C, Kim JJ
  Title
Structure and mechanism of action of the acyl-CoA dehydrogenases.
  Journal
FASEB J 9:718-25 (1995)
DOI:10.1096/fasebj.9.9.7601336
Reference
6  [PMID:3968063]
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K.
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J Biol Chem 260:1311-25 (1985)
  Sequence
[rno:64304]
Reference
7  [PMID:16024185]
  Authors
McMahon B, Gallagher ME, Mayhew SG
  Title
The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA  dehydrogenase that oxidises only short-chain aliphatic substrates.
  Journal
FEMS Microbiol Lett 250:121-7 (2005)
DOI:10.1016/j.femsle.2005.06.049
  Sequence
[ppu:PP_2216]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.1
IUBMB Enzyme Nomenclature: 1.3.8.1
ExPASy - ENZYME nomenclature database: 1.3.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.8.1
BRENDA, the Enzyme Database: 1.3.8.1
CAS: 9027-88-7

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