KEGG   ENZYME: 1.3.8.9
Entry
EC 1.3.8.9                  Enzyme                                 
Name
very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R01279 R03990
Substrate
very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K09479  very long chain acyl-CoA dehydrogenase
Genes
HSA37(ACADVL)
PTR455237(ACADVL)
PPS100986379(ACADVL)
GGO101143346(ACADVL)
PON100454381(ACADVL)
NLE100585921(ACADVL)
HMH116459317(ACADVL)
MCC714326(ACADVL)
MCF101925858(ACADVL)
MTHB126939682
MNI105473163(ACADVL)
CSAB103242278(ACADVL)
CATY105582769(ACADVL)
PANU101018882(ACADVL)
TGE112608977(ACADVL)
MLEU105549907(ACADVL)
RRO104673335(ACADVL)
RBB108514298(ACADVL)
TFN117067801(ACADVL)
PTEH111521283(ACADVL)
CANG105523588(ACADVL)
CJC100399197(ACADVL)
SBQ101028298(ACADVL)
CIMI108306602(ACADVL)
CSYR103263239(ACADVL)
MMUR105877978(ACADVL)
LCAT123650853(ACADVL)
PCOQ105819433(ACADVL)
OGA100947350(ACADVL)
MMU11370(Acadvl)
MCAL110304163(Acadvl)
MPAH110332221(Acadvl)
RNO25363(Acadvl)
MCOC116079063(Acadvl)
ANU117711753(Acadvl)
MUN110555097(Acadvl)
CGE100767527(Acadvl)
MAUA101824933(Acadvl)
PROB127219014(Acadvl)
PLEU114693210(Acadvl)
MORG121456541(Acadvl)
MFOT126513897
AAMP119811176(Acadvl)
NGI103752159(Acadvl)
HGL101707761(Acadvl)
CPOC100713909(Acadvl)
CCAN109674520(Acadvl)
DORD105983460(Acadvl)
DSP122100421(Acadvl)
PLOP125365206(Acadvl)
NCAR124981031
MMMA107157970(Acadvl)
OCU100346654
OPI101517023(ACADVL)
TUP102486032(ACADVL)
GVR103591441(ACADVL)
CFA489463(ACADVL)
CLUD112647487(ACADVL)
VVP112924990(ACADVL)
VLG121499762(ACADVL)
NPO129496982(ACADVL)
AML100472785(ACADVL)
UMR103660348(ACADVL)
UAH113271108(ACADVL)
UAR123792174(ACADVL)
ELK111161073
LLV125087809
MPUF101679496(ACADVL)
MNP132003338(ACADVL)
MLK131815752(ACADVL)
NVS122906685(ACADVL)
ORO101376612(ACADVL)
EJU114225362(ACADVL)
ZCA113939372(ACADVL)
MLX117999991(ACADVL)
NSU110584452(ACADVL)
LWW102738302(ACADVL)
FCA101094144(ACADVL)
PYU121016030(ACADVL)
PCOO112856982
PBG122484852(ACADVL)
LRUF124519482
PTG102968012(ACADVL)
PPAD109245981(ACADVL)
PUC125927068
AJU106972414
HHV120231442(ACADVL)
BTA282130(ACADVL)
BOM102273950
BIU109573934(ACADVL)
BBUB102405745(ACADVL)
BBIS104993930(ACADVL)
CHX102181987(ACADVL)
OAS101117173(ACADVL)
BTAX128064846(ACADVL)
ODA120866080(ACADVL)
CCAD122446217(ACADVL)
MBEZ129542624(ACADVL)
SSC100520636(ACADVL)
CFR102516576(ACADVL)
CBAI105077481(ACADVL)
CDK105103048(ACADVL)
VPC102539565(ACADVL)
BACU103000307(ACADVL)
LVE103077095(ACADVL)
OOR101275668(ACADVL)
DLE111185665(ACADVL)
PCAD102973774(ACADVL)
PSIU116745056(ACADVL)
NASI112390407(ACADVL)
ECB100061583(ACADVL)
EPZ103557744(ACADVL)
EAI106844174(ACADVL)
MYB102257348(ACADVL)
MYD102774563(ACADVL)
MMYO118672042(ACADVL)
MLF102423177(ACADVL)
MNA107544584(ACADVL)
PKL118726931(ACADVL)
EFUS103296934(ACADVL)
HAI109394616(ACADVL)
DRO112308631(ACADVL)
SHON118974685(ACADVL)
AJM119037137(ACADVL)
PDIC114514993(ACADVL)
PHAS123809242(ACADVL)
MMF118633802(ACADVL)
RFQ117012846(ACADVL)
PPAM129072309(ACADVL)
PALE102879612(ACADVL)
PGIG120589632(ACADVL)
PVP105291734(ACADVL)
RAY107509515(ACADVL)
MJV108401220(ACADVL)
TOD119232659(ACADVL)
SARA101545206(ACADVL)
LAV100657276(ACADVL)
TMU101361348
ETF101645138(ACADVL)
DNM101438130(ACADVL)
MDO100016619(ACADVL) 100032148
GAS123242000 123244462(ACADVL)
SHR100925698 100931501(ACADVL)
AFZ127558293 127560911
PCW110193114 110194404(ACADVL)
OAA100089853(ACADVL)
LSR110482134(ACADVL)
CCAE111922435(ACADVL)
SVG106864280(ACADVL)
ACHC115338360(ACADVL)
AGEN126034670
AAM106485823(ACADVL)
AROW112962139(ACADVL) 112963323
NPD112947461(ACADVL)
TGT104573439(ACADVL)
DNE112981697(ACADVL)
SCAM104153221(ACADVL)
ASN102371669 102384902(ACADVL)
AMJ102568802(ACADVL) 102576922
CPOO109308570(ACADVL)
GGN109288127(ACADVL)
PSS102443861(ACADVL) 102456803
CMY102938508(ACADVL)
CCAY125628616(ACADVL) 125642751
DCC119849363 119861618 122457698
CPIC101946768 101948805(ACADVL)
TST117883233(ACADVL)
CABI116828964 116839188(ACADVL)
MRV120372442 120381766(ACADVL)
ASAO132777544(ACADVL)
PVT110082312(ACADVL)
SUND121933466(ACADVL)
PBI103051941 103059781(ACADVL)
PMUR107291707 107295343(ACADVL)
CTIG120305692(ACADVL) 120307167
TSR106542417(ACADVL) 106551584
PGUT117656436 117659250 117669843
APRI131196872(ACADVL) 131200568
PTEX113450919(ACADVL)
NSS113425170(ACADVL)
VKO123016648(ACADVL)
PMUA114581599(ACADVL) 114598214
PRAF128400158(ACADVL) 128414927
ZVI118093983 118094793(ACADVL)
HCG128331405(ACADVL) 128349410
GJA107118083(ACADVL) 107125630
STOW125445140(ACADVL)
EMC129331940 129340369(ACADVL)
XLA108711808(acadvl.L)
XTR100216267(acadvl)
RTEM120921798(ACADVL)
BBUF120986711(ACADVL)
BGAR122922346(ACADVL)
MUO115457771(ACADVL)
GSH117350647(ACADVL)
DRE573723(acadvl)
SRX107731915 107738021
SANH107675499 107683542(acadvl)
SGH107595296 107597078
CCAR109073618 109092601
CAUA113052224 113105619
CGIB127961630 128017217
PTET122349779(acadvl)
LROH127167632(acadvl)
OMC131543239(acadvl)
PPRM120469949(acadvl)
RKG130091451(acadvl)
MAMB125265528(acadvl)
CIDE127515814
MASI127415437 127417077 127433914
TROS130545585 130546066(acadvl) 130550983
TDW130417368(acadvl) 130419068
MANU129438883(acadvl)
IPU108267840
IFU128610167(acadvl)
PHYP113540141(acadvl)
SMEO124387396(acadvl)
TFD113654726(acadvl)
TVC132848746(acadvl)
AMEX103045531(acadvl)
CMAO118826677(acadvl)
EEE113567683(acadvl)
CHAR105906682 105907142(acadvl)
TRU101069830(acadvl)
TFS130522023(acadvl)
TNGGSTEN00019248G001
LCO104937817(acadvl)
NCC104942951
TBEN117488099(acadvl)
CGOB115023469(acadvl)
PGEO117463629(acadvl)
GACU117552716(acadvl)
ELY117246106(acadvl)
EFO125883637(acadvl)
SLUC116048989(acadvl)
ECRA117934572(acadvl)
ESP116686337(acadvl)
PFLV114545512(acadvl)
GAT120821571(acadvl)
PPUG119222335(acadvl)
AFB129093499(acadvl)
CLUM117747431(acadvl)
MSAM119911752(acadvl)
SCHU122870721(acadvl)
CUD121504728(acadvl)
ALAT119026810(acadvl)
MZE101472773(acadvl)
ONL100703037(acadvl)
OAU116330727(acadvl)
OLA101165349(acadvl)
OML112156048(acadvl)
XMA102217028(acadvl)
XCO114157390(acadvl)
XHE116732534(acadvl)
PRET103480485(acadvl)
PFOR103137528(acadvl)
PLAI106945534(acadvl)
PMEI106906747(acadvl)
GAF122819841(acadvl)
CVG107087781(acadvl)
CTUL119789781(acadvl)
GMU124880174(acadvl)
NFU107372430(acadvl)
KMR108241814(acadvl)
ALIM106529201(acadvl)
NWH119416326(acadvl)
AOCE111575585(acadvl)
MCEP124997830(acadvl)
CSEM103386901(acadvl)
POV109634887(acadvl)
SSEN122766124(acadvl)
HHIP117752053(acadvl)
HSP118102302(acadvl)
LCF108897054
SDU111232992(acadvl)
SLAL111665745(acadvl)
XGL120797419(acadvl)
HCQ109506947(acadvl)
SSCV125981931
SBIA133494776(acadvl)
PEE133397629(acadvl)
PTAO133472714(acadvl)
BPEC110157677(acadvl)
MALB109966474(acadvl)
BSPL114843947(acadvl)
SJO128383753(acadvl)
SASA106602820(acadvl)
STRU115155021(acadvl)
OTW112216747(acadvl)
OMY110490130(acadvl)
OGO123994754(acadvl)
ONE115106836(acadvl)
OKI109864415(acadvl)
OKE118365919(acadvl)
SALP111950426(acadvl)
SNH120057400(acadvl)
CCLU121579727(acadvl)
ELS105010800(acadvl)
SFM108918781(acadvl) 108923151
PKI111860921(acadvl)
AANG118222760(acadvl)
LOC102693936(acadvl)
PSPA121306545(acadvl)
ARUT117404600 117967919
PSEX120524994(acadvl)
LCM102364546(ACADVL)
RTP109912656 109918899(acadvl)
CPLA122544279(acadvl) 122556076
HOC132821718 132835154
LERI129694004(acadvl) 129703268
PMRN116944603(ACADVL)
LRJ133340840(ACADVL)
BFO118427578
BBEL109463957
CIN100183990
SCLV120328435
SPU584710
LPIC129279127
APLC110981027
AJC117106771
SKO100369524
DMEDmel_CG7461(Acadvl)
DER6547331
DSE6609917
DSIDsimw501_GD11444(Dsim_GD11444)
DYADyak_GE12038
DAN6506293
DSR110177854
DPO26532094
DPE6602657
DMN117188910
DGR6557587
DMODmoj_GI12099
DAZ108614533
DNV108651701
DHE111592309
DVI6623490
CCAT101461538
BOD106622331
BDR105223246
RZE108354643 108361541 108378210
TDA119687575
MDE101891231
SCAC106091613
LCQ111683083 111683088 111683092
LSQ119608560 119608561 119608567
GFS119642989
ECOE129938849
HIS119651165
AGA1275626 133393306 133394118 133394119
ACOZ120958362 120958363 120958364 120958365
AARA120901834 120902053 120902103 120904618
AMER121597151 121597152 121597153 121597155
ASTE118511710 118511711 118511712 118511713
AFUN125766327 125766329 125766330 125766331
AMOU128302062 128302063 128304425 128305932
AALI118462065 118462066 118462067
AAG23687873 5565366 5565367
AALB109400327 109400349 109425168 109425169
CQUCpipJ_CPIJ016451 CpipJ_CPIJ016452 CpipJ_CPIJ016453 CpipJ_CPIJ016454
CPII120417357 120417361 120417378
CNS116336875
BCOO119085955
AME412025
ACER107993296
ALAB122713268
ADR102672182
AFLR100865647
BIM100747671
BBIF117207816
BVK117238208
BVAN117160011
BTER100651720
BAFF126919937
BPYO122570882
BPAS132906335
FVI122531524
CCAL108632159
OBB114874036
MGEN117225101
NMEA116431343
CGIG122404056
SOC105200554
MPHA105838446
AEC105149521
ACEP105622411
PBAR105429882
VEM105562928
HST105188087
DQU106746266
CFO105251587
FEX115241390
LHU105667331
PGC109854598
OBO105276471
PCF106788263
PFUC122517614
VPS122637938
VCRB124432788
NVI100116828
CSOL105368265
TPRE106657066
LHT122497687
LBD127286425
MDL103574466
CGLO123261711
FAS105263418
DAM107047818
AGIF122849565 122855670
CINS118069543
VCAN122415786
CCIN107274922
DSM124411841
NPT124218768
NFB124183961
NLO107223127
NVG124306365
TCA659957
DPA109541041
SOY115876810
AGRG126748220
ATD109601372
CSET123317940
AGB108910959
NVL108562362 108569494
APLN108741828
PPYR116160986
OTU111425163
BMOR101744941
BMAN114241040
MSEX115450554 119192036
DPLKGM_210602
BANY112050744
MJU123877800
NIQ126771213
VCD124543694
MCIX123663235
PMAC106710891
PXU106124808
PRAP110996061
PBX123714584
PNAP125059555
ZCE119829410
CCRC123702246
LSIN126976352
HAW110380632
HZE124630404
TNL113500974
SLIU111353597
OFU114364297
PGW126373682
CFEL113381136
CCRN123302345
API100162051
DNX107164135
AGS114127836 114127838
RMD113560282
ACOO126835221
DVT126910520
BTAB109036499
DCI103511783
CLEC106668658
HHAL106691567
NLU111057385
HVI124362786
MQU128990136
PHUPhum_PHUM617730
FOC113203933
ZNE110832869
CSEC111868786
SGRE126351366
IEL124153573
FCD110843829
DPXDAPPUDRAFT_327246
DMK116922047
DPZ124336955
PVM113813193 113823665
PJA122259512
PCHN125031151
PMOO119580640
HAME121878582
PCLA123762221
CQD128697150
PTRU123513027
ESN126982288
HAZT108669783
EAF111695316
LSM121122352 121126155
TCF131890658
PPOI119109527
DSV119439895
RSAN119386460
RMP119178100
VDE111251465
VJA111270259
TUT107362076
DPTE113799491
DFR124496042
CSCU111630174
PTEP107450301
UDV129219424 129232459
SDM118184637 118199840
LPOL106465874
PMEO129599287
CELCELE_E04F6.5(acdh-12)
CBRCBG_13088
CRQGCK72_006440
NAINECAME_17750
BMYBM_BM3112(Bma-acdh-12)
LOALOAG_00695
TSPTsp_10283
HROHELRODRAFT_186034
LGILOTGIDRAFT_177715
PVUL126815130
PCAN112555772
BGT106055817
GAE121375144
HRF124145143
HRJ124282755
CRG105344745
CVN111135491
CANU128181060
OED125659500 125667826
MYI110463202
PMAX117342228
MCAF127737844
MMER123553917
RPHI132750528
DPOL127834180
OBI106875659
OSN115209819
LAK106158444
OVIT265_06522
NVE5510970
EPA110251159
ATEN116295518
ADF107343075
AMIL114953943
PDAM113681975
SPIS111335626
DGT114521443
XEN124446405
HMG100201063
HSY130636588
TADTRIADDRAFT_20833 TRIADDRAFT_23854 TRIADDRAFT_30874 TRIADDRAFT_31731 TRIADDRAFT_31757 TRIADDRAFT_31810 TRIADDRAFT_34622
AQU100638454
GAUGAU_0440
 » show all
Reference
1  [PMID:1730632]
  Authors
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
  Title
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
  Journal
J Biol Chem 267:1027-33 (1992)
  Sequence
[rno:25363]
Reference
2  [PMID:7769092]
  Authors
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
  Title
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
  Journal
J Clin Invest 95:2465-73 (1995)
DOI:10.1172/JCI117947
  Sequence
[hsa:37]
Reference
3  [PMID:18227065]
  Authors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
  Title
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
  Journal
J Biol Chem 283:9435-43 (2008)
DOI:10.1074/jbc.M709135200
  Sequence
[hsa:37]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.9
IUBMB Enzyme Nomenclature: 1.3.8.9
ExPASy - ENZYME nomenclature database: 1.3.8.9
BRENDA, the Enzyme Database: 1.3.8.9

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