KEGG ENZYME: 1.3.8.9

ENZYME: 1.3.8.9

Entry

EC 1.3.8.9                  Enzyme

Name

very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor

Sysname

very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Reaction(IUBMB)

a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

Reaction(KEGG)

(other) R01279 R03990

Substrate

very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]

Product

very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]

Comment

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.

History

EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9

Pathway

ec00071

Fatty acid degradation

ec01100

Metabolic pathways

Orthology

K09479

very long chain acyl-CoA dehydrogenase

Genes

HSA:	37(ACADVL)

PTR:	455237(ACADVL)

PPS:	100986379(ACADVL)

GGO:	101143346(ACADVL)

PON:	100454381(ACADVL)

NLE:	100585921(ACADVL)

MCC:	714326(ACADVL)

MCF:	101925858(ACADVL)

CSAB:

103242278(ACADVL)

CATY:

105582769(ACADVL)

PANU:

101018882(ACADVL)

TGE:	112608977(ACADVL)

RRO:	104673335(ACADVL)

RBB:	108514298(ACADVL)

TFN:	117067801(ACADVL)

PTEH:

111521283(ACADVL)

CJC:	100399197(ACADVL)

SBQ:	101028298(ACADVL)

CSYR:

103263239(ACADVL)

MMUR:

105877978(ACADVL)

OGA:	100947350(ACADVL)

MMU:	11370(Acadvl)

MCAL:

110304163(Acadvl)

MPAH:

110332221(Acadvl)

RNO:	25363(Acadvl)

MCOC:

116079063(Acadvl)

MUN:	110555097(Acadvl)

CGE:	100767527(Acadvl)

PLEU:

114693210(Acadvl)

NGI:	103752159(Acadvl)

HGL:	101707761(Acadvl)

CPOC:

100713909(Acadvl)

CCAN:

109674520(Acadvl)

DORD:

105983460(Acadvl)

DSP:	122100421(Acadvl)

OCU:	100346654(ACADVL)

OPI:	101517023(ACADVL)

TUP:	102486032(ACADVL)

CFA:	489463(ACADVL)

VVP:	112924990(ACADVL)

VLG:	121499762(ACADVL)

AML:	100472785(ACADVL)

UMR:	103660348(ACADVL)

UAH:	113271108(ACADVL)

UAR:	123792174(ACADVL)

ELK:

111161073

LLV:

125087809

MPUF:

101679496(ACADVL)

ORO:	101376612(ACADVL)

EJU:	114225362(ACADVL)

ZCA:	113939372(ACADVL)

MLX:	117999991(ACADVL)

FCA:	101094144(ACADVL)

PYU:	121016030(ACADVL)

PBG:	122484852(ACADVL)

PTG:	102968012(ACADVL)

PPAD:

109245981(ACADVL)

AJU:	106972414(ACADVL)

HHV:	120231442(ACADVL)

BTA:	282130(ACADVL)

BOM:

102273950

BIU:	109573934(ACADVL)

BBUB:

102405745(ACADVL)

CHX:	102181987(ACADVL)

OAS:	101117173(ACADVL)

ODA:	120866080(ACADVL)

CCAD:

122446217(ACADVL)

SSC:	100520636(ACADVL)

CFR:	102516576(ACADVL)

CBAI:

105077481(ACADVL)

CDK:	105103048(ACADVL)

VPC:	102539565(ACADVL)

BACU:

103000307(ACADVL)

LVE:	103077095(ACADVL)

OOR:	101275668(ACADVL)

DLE:	111185665(ACADVL)

PCAD:

102973774(ACADVL)

PSIU:

116745056(ACADVL)

ECB:	100061583(ACADVL)

EPZ:	103557744(ACADVL)

EAI:	106844174(ACADVL)

MYB:	102257348(ACADVL)

MYD:	102774563(ACADVL)

MMYO:

118672042(ACADVL)

MLF:	102423177(ACADVL)

MNA:	107544584(ACADVL)

PKL:	118726931(ACADVL)

HAI:	109394616(ACADVL)

DRO:	112308631(ACADVL)

SHON:

118974685(ACADVL)

AJM:	119037137(ACADVL)

PDIC:

114514993(ACADVL)

PHAS:

123809242(ACADVL)

MMF:	118633802(ACADVL)

RFQ:	117012846(ACADVL)

PALE:

102879612(ACADVL)

PGIG:

120589632(ACADVL)

PVP:	105291734(ACADVL)

RAY:	107509515(ACADVL)

MJV:	108401220(ACADVL)

TOD:	119232659(ACADVL)

SARA:

101545206(ACADVL)

LAV:	100657276(ACADVL)

TMU:

101361348

DNM:	101438130(ACADVL)

MDO:	100016619(ACADVL) 100032148

GAS:	123242000 123244462(ACADVL)

SHR:	100925698 100931501(ACADVL)

PCW:	110193114 110194404(ACADVL)

OAA:	100089853(ACADVL)

LSR:	110482134(ACADVL)

CCAE:

111922435(ACADVL)

ACHC:

115338360(ACADVL)

AAM:	106485823(ACADVL)

AROW:

112962139(ACADVL) 112963323

NPD:	112947461(ACADVL)

DNE:	112981697(ACADVL)

ASN:	102371669 102384902(ACADVL)

AMJ:	102568802(ACADVL) 102576922

CPOO:

109308570(ACADVL)

GGN:	109288127(ACADVL)

PSS:	102443861(ACADVL) 102456803

CMY:	102938508(ACADVL)

CPIC:

101946768 101948805(ACADVL)

TST:	117883233(ACADVL)

CABI:

116828964 116839188(ACADVL)

MRV:	120372442 120381766(ACADVL)

PVT:	110082312(ACADVL)

SUND:

121933466(ACADVL)

PBI:	103051941 103059781(ACADVL)

PMUR:

107291707 107295343(ACADVL)

TSR:	106542417(ACADVL) 106551584

PGUT:

117656436 117659250 117669843

VKO:	123016648(ACADVL)

PMUA:

114581599(ACADVL) 114598214

ZVI:	118093983 118094793(ACADVL)

GJA:	107118083(ACADVL) 107125630

XLA:	108711808(acadvl.L)

XTR:	100216267(acadvl)

RTEM:

120921798(ACADVL)

BBUF:

120986711(ACADVL)

BGAR:

122922346(ACADVL)

DRE:	573723(acadvl)

SRX:	107731915 107738021

SANH:

107675499 107683542(acadvl)

SGH:	107595296 107597078

CCAR:

109073618 109092601

CAUA:

113052224 113105619

IPU:	108267840(acadvl)

PHYP:

113540141(acadvl)

SMEO:

124387396(acadvl)

AMEX:

103045531(acadvl)

EEE:	113567683(acadvl)

TRU:	101069830(acadvl)

TNG:	GSTEN00019248G001

LCO:	104937817(acadvl)

NCC:

104942951

CGOB:

115023469(acadvl)

ELY:	117246106(acadvl)

SLUC:

116048989(acadvl)

ECRA:

117934572(acadvl)

PFLV:

114545512(acadvl)

GAT:	120821571(acadvl)

PPUG:

119222335(acadvl)

MSAM:

119911752(acadvl)

CUD:	121504728(acadvl)

MZE:	101472773(acadvl)

ONL:	100703037(acadvl)

OAU:	116330727(acadvl)

OLA:	101165349(acadvl)

OML:	112156048(acadvl)

XMA:	102217028(acadvl)

XCO:	114157390(acadvl)

XHE:	116732534(acadvl)

PRET:

103480485(acadvl)

PFOR:

103137528(acadvl)

PLAI:

106945534(acadvl)

PMEI:

106906747(acadvl)

GAF:	122819841(acadvl)

CVG:	107087781(acadvl)

CTUL:

119789781(acadvl)

GMU:	124880174(acadvl)

NFU:	107372430(acadvl)

KMR:	108241814(acadvl)

ALIM:

106529201(acadvl)

NWH:	119416326(acadvl)

AOCE:

111575585(acadvl)

CSEM:

103386901(acadvl)

POV:	109634887(acadvl)

SSEN:

122766124(acadvl)

HHIP:

117752053(acadvl)

LCF:	108897054(acadvl)

SDU:	111232992(acadvl)

SLAL:

111665745(acadvl)

XGL:	120797419(acadvl)

HCQ:	109506947(acadvl)

BPEC:

110157677(acadvl)

MALB:

109966474(acadvl)

SASA:

106602820(acadvl)

OTW:	112216747(acadvl)

OMY:	110490130(acadvl)

OGO:	123994754(acadvl)

ONE:	115106836(acadvl)

SALP:

111950426(acadvl)

SNH:	120057400(acadvl)

ELS:	105010800(acadvl)

SFM:	108918781(acadvl) 108923151

PKI:	111860921(acadvl)

AANG:

118222760(acadvl)

LOC:	102693936(acadvl)

PSPA:

121306545(acadvl)

ARUT:

117404600 117967919

LCM:	102364546(ACADVL)

RTP:	109912656 109918899(acadvl)

BFO:

118427578

BBEL:

109463957

CIN:

100183990

SCLV:

120328435

SPU:

584710

APLC:

110981027

SKO:

100369524

DME:	Dmel_CG7461(CG7461)

DER:

6547331

DSE:

6609917

DSI:	Dsimw501_GD11444(Dsim_GD11444)

DYA:	Dyak_GE12038

DAN:

6506293

DSR:

110177854

DPE:

6602657

DMN:

117188910

DGR:

6557587

DMO:	Dmoj_GI12099

DAZ:

108614533

DNV:

108651701

DHE:

111592309

DVI:

6623490

CCAT:

101461538

BOD:

106622331

MDE:

101891231

SCAC:

106091613

LCQ:

111683088

AGA:	AgaP_AGAP008769

ACOZ:

120958362 120958363 120958364 120958365

AARA:

120901834 120902053 120902103 120904618

AAG:	23687873 5565366 5565367

AALB:

109400327 109400349 109425168 109425169

CQU:	CpipJ_CPIJ016451 CpipJ_CPIJ016452 CpipJ_CPIJ016453 CpipJ_CPIJ016454

CPII:

120417357 120417361 120417378

CNS:

116336875

AME:

412025

ACER:

107993296

ALAB:

122713268

BIM:

100747671

BBIF:

117207816

BVK:

117238208

BVAN:

117160011

BTER:

100651720

BPYO:

122570882

CCAL:

108632159

OBB:

114874036

MGEN:

117225101

NMEA:

116431343

CGIG:

122404056

SOC:

105200554

MPHA:

105838446

AEC:

105149521

ACEP:

105622411

PBAR:

105429882

VEM:

105562928

HST:

105188087

DQU:

106746266

CFO:

105251587

FEX:

115241390

LHU:

105667331

PGC:

109854598

OBO:

105276471

PCF:

106788263

PFUC:

122517614

VPS:

122637938

NVI:

100116828

CSOL:

105368265

TPRE:

106657066

MDL:

103574466

CGLO:

123261711

FAS:

105263418

DAM:

107047818

AGIF:

122849565 122855670

CCIN:

107274922

TCA:

659957

DPA:

109541041

SOY:

115876810

ATD:

109601372

CSET:

123317940

AGB:

108910959

NVL:	108562362 108569494

APLN:

108741828

PPYR:

116160986

OTU:

111425163

BMOR:

101744941

BMAN:

114241040

MSEX:

115450554 119192036

DPL:	KGM_210602

BANY:

112050744

PMAC:

106710891

PXU:

106124808

PRAP:

110996061

ZCE:

119829410

HAW:

110380632

TNL:

113500974

OFU:

114364297

API:

100162051

DNX:

107164135

AGS:	114127836 114127838

RMD:

113560282

BTAB:

109036499

DCI:

103511783

CLEC:

106668658

HHAL:

106691567

NLU:

111057385

PHU:	Phum_PHUM617730

FOC:

113203933

ZNE:

110832869

CSEC:

111868786

FCD:

110843829

DPX:	DAPPUDRAFT_327246

DMK:

116922047

PVM:	113813193 113823665

PJA:

122259512

HAME:

121878582

PCLA:

123762221

PTRU:

123513027

HAZT:

108669783

EAF:

111695316

DSV:

119439895

RSAN:

119386460

RMP:

119178100

VDE:

111251465

VJA:

111270259

TUT:

107362076

DPTE:

113799491

DFR:

124496042

CSCU:

111630174

PTEP:

107450301

SDM:	118184637 118199840

CEL:	CELE_E04F6.5(acdh-12)

CBR:

CBG_13088

BMY:	BM_BM3112(Bma-acdh-12)

LOA:	LOAG_00695

NAI:	NECAME_17750

TSP:

Tsp_10283

HRO:	HELRODRAFT_186034

LGI:	LOTGIDRAFT_177715

PCAN:

112555772

BGT:

106055817

GAE:

121375144

HRF:

124145143

HRJ:

124282755

CRG:

105344745

MYI:

110463202

PMAX:

117342228

MMER:

123553917

OBI:

106875659

OSN:

115209819

LAK:

106158444

OVI:	T265_06522

NVE:

5510970

EPA:

110251159

ATEN:

116295518

ADF:

107343075

AMIL:

114953943

PDAM:

113681975

SPIS:

111335626

DGT:

114521443

XEN:

124446405

HMG:

100201063

TAD:	TRIADDRAFT_20833 TRIADDRAFT_23854 TRIADDRAFT_30874 TRIADDRAFT_31731 TRIADDRAFT_31757 TRIADDRAFT_31810 TRIADDRAFT_34622

AQU:

100638454

GAU:

GAU_0440

» show all

Reference

1 [PMID:1730632]

Authors

Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T

Title

Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.

Journal

J Biol Chem 267:1027-33 (1992)

Sequence

[rno:25363]

Reference

2 [PMID:7769092]

Authors

Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T

Title

Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.

Journal

J Clin Invest 95:2465-73 (1995)
DOI:10.1172/JCI117947

Sequence

[hsa:37]

Reference

3 [PMID:18227065]

Authors

McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ

Title

Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.

Journal

J Biol Chem 283:9435-43 (2008)
DOI:10.1074/jbc.M709135200

Sequence

[hsa:37]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.8.9

IUBMB Enzyme Nomenclature:

1.3.8.9

ExPASy - ENZYME nomenclature database:

1.3.8.9

BRENDA, the Enzyme Database:

1.3.8.9

DBGET integrated database retrieval system