Entry
Name
very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
Substrate
very-long-chain acyl-CoA [CPD:
C20876 ];
electron-transfer flavoprotein [CPD:
C04253 ]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:
C20879 ];
reduced electron-transfer flavoprotein [CPD:
C04570 ]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC
1.3.8.1 , short-chain acyl-CoA dehydrogenase, EC
1.3.8.7 , medium-chain acyl-CoA dehydrogenase, and EC
1.3.8.8 , long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
Pathway
Orthology
K09479 very long chain acyl-CoA dehydrogenase
Genes
MDO : 100016619(ACADVL) 100032148
GAS : 123242000 123244462(ACADVL)
SHR : 100925698 100931501(ACADVL)
PCW : 110193114 110194404(ACADVL)
AROW : 112962139(ACADVL) 112963323
ASN : 102371669 102384902(ACADVL)
AMJ : 102568802(ACADVL) 102576922
PSS : 102443861(ACADVL) 102456803
CPIC : 101946768 101948805(ACADVL)
CABI : 116828964 116839188(ACADVL)
MRV : 120372442 120381766(ACADVL)
PBI : 103051941 103059781(ACADVL)
PMUR : 107291707 107295343(ACADVL)
CTIG : 120305692(ACADVL) 120307167
TSR : 106542417(ACADVL) 106551584
PGUT : 117656436 117659250 117669843
PMUA : 114581599(ACADVL) 114598214
ZVI : 118093983 118094793(ACADVL)
GJA : 107118083(ACADVL) 107125630
SANH : 107675499 107683542(acadvl)
CCAR : 109073618 109092601
CAUA : 113052224 113105619
CGIB : 127961630 128017217
MASI : 127415437 127417077 127433914
SFM : 108918781(acadvl) 108923151
ARUT : 117404600 117967919
RTP : 109912656 109918899(acadvl)
CPLA : 122544279(acadvl) 122556076
DSI : Dsimw501_GD11444(Dsim_GD11444)
RZE : 108354643 108361541 108378210
LSQ : 119608560 119608561 119608567
ACOZ : 120958362 120958363 120958364 120958365
AARA : 120901834 120902053 120902103 120904618
ASTE : 118511710 118511711 118511712 118511713
AAG : 23687873 5565366 5565367
AALB : 109400327 109400349 109425168 109425169
CQU : CpipJ_CPIJ016451 CpipJ_CPIJ016452 CpipJ_CPIJ016453 CpipJ_CPIJ016454
CPII : 120417357 120417361 120417378
AGIF : 122849565 122855670
MSEX : 115450554 119192036
CEL : CELE_E04F6.5(acdh-12)
BMY : BM_BM3112(Bma-acdh-12)
TAD : TRIADDRAFT_20833 TRIADDRAFT_23854 TRIADDRAFT_30874 TRIADDRAFT_31731 TRIADDRAFT_31757 TRIADDRAFT_31810 TRIADDRAFT_34622
» show all
Taxonomy
Reference
Authors
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
Title
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
Journal
J Biol Chem 267:1027-33 (1992)
Sequence
Reference
Authors
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
Title
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
Journal
Sequence
Reference
Authors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
Title
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.9
ExPASy - ENZYME nomenclature database: 1.3.8.9
BRENDA, the Enzyme Database: 1.3.8.9