KEGG   ENZYME: 2.1.1.354Help
Entry
EC 2.1.1.354                Enzyme                                 

Name
[histone H3]-lysine4 N-trimethyltransferase;
KMT2A (gene name);
KMT2B (gene name);
KMT2C (gene name);
KMT2D (gene name);
KMT2E (gene name);
KMT2F (gene name);
KMT2G (gene name);
KMT2H (gene name);
KMT3C (gene name);
KMT3D (gene name);
KMT3E (gene name);
KMT7 (gene name);
PRDM7 (gene name);
PRDM9 (gene name);
MLL1 (gene name);
MLL2 (gene name);
MLL3 (gene name);
MLL4 (gene name);
MLL5 (gene name);
SETD1A (gene name);
ASH1L (gene name);
SMYD1 (gene name);
SMYD2 (gene name);
SMYD3 (gene name);
SET7/9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Comment
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. Unlike the other enzymes, KMT7 catalyses only monomethylation.
History
EC 2.1.1.354 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD
K11431  [histone H3]-lysine4 N-trimethyltransferase SETD7
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3
Genes
HSA: 11105(PRDM7) 150572(SMYD1) 23067(SETD1B) 4297(KMT2A) 55870(ASH1L) 55904(KMT2E) 56950(SMYD2) 56979(PRDM9) 58508(KMT2C) 64754(SMYD3) 8085(KMT2D) 80854(SETD7) 9739(SETD1A) 9757(KMT2B)
PTR: 100610362(KMT2D) 107968713(PRDM7) 107971434(ASH1L) 451587(KMT2A) 455959(KMT2B) 457729(SMYD2) 457870(SMYD3) 459386(SMYD1) 461944(PRDM9) 463640(KMT2E) 463875(KMT2C) 468101(SETD1A) 473295(SETD1B) 737682(SETD7)
PPS: 100971786(SMYD2) 100972983(SETD1A) 100979249(KMT2B) 100979709(ASH1L) 100981554(SETD7) 100982828(KMT2E) 100983230(SMYD1) 100984332(KMT2A) 100985657(SETD1B) 100990317(SMYD3) 100992231(KMT2C) 100993054(PRDM9) 100995808(KMT2D)
GGO: 101129366(KMT2A) 101134264(ASH1L) 101134599(KMT2C) 101135995(PRDM7) 101136369(PRDM9) 101136477(SETD7) 101139923(KMT2B) 101144774(KMT2D) 101144971(KMT2E) 101145998(SMYD3) 101146341(SMYD1) 101147890(SMYD2)
PON: 100172280(SMYD1) 100173903(KMT2E) 100432076(SETD1A) 100435324(SETD1B) 100439269(SMYD3) 100439693(PRDM9) 100439768(SMYD2) 100440639(PRDM7) 100441102(KMT2A) 100441715(KMT2D) 100442005(KMT2B) 100449956(SETD7) 100450852(KMT2C)
NLE: 100579604(SMYD3) 100580011(ASH1L) 100583589(PRDM9) 100584028(SETD1B) 100586637(KMT2D) 100594433(KMT2B) 100600051(KMT2E) 100602268(SETD1A) 100602353(SETD7) 100603309(SMYD2) 100603551(SMYD1) 100604245(KMT2A) 100607151(KMT2C) 100607333(PRDM7)
MCC: 100427538(PRDM7) 695034(PRDM9) 697233(KMT2E) 698950(SMYD1) 700426(SETD7) 703402(SMYD3) 703717(SETD1B) 705511(KMT2A) 709375(SMYD2) 710795(KMT2D) 712416(SETD1A) 716753(KMT2C) 717778(ASH1L) 718835(KMT2B)
MCF: 101867084(ASH1L) 101926094(KMT2E) 102115861(KMT2B) 102120149(SMYD3) 102120758(SMYD1) 102123137(SETD1B) 102123773(KMT2D) 102126119(PRDM7) 102128002(KMT2C) 102134166(SETD1A) 102136354(PRDM9) 102140141(SETD7) 102141885(SMYD2)
CSAB: 103215061(PRDM9) 103223879(ASH1L) 103226692(KMT2E) 103227268(KMT2C) 103230106(SMYD2) 103230910(SMYD3) 103231168(SETD1A) 103234531(KMT2B) 103236281(SETD7) 103238253(KMT2D) 103239290(SETD1B) 103241358(SMYD1) 103248594(KMT2A)
RRO: 104654337(SETD7) 104659604(ASH1L) 104661596(SETD1A) 104665589(KMT2A) 104666361(SETD1B) 104667085(KMT2B) 104669844(SMYD2) 104674171(SMYD1) 104674292(PRDM7) 104675848(KMT2E) 104676513(SMYD3) 104677903 104678716(KMT2C) 104679726(KMT2D)
RBB: 108512323(KMT2B) 108515913 108518888(SMYD1) 108522758(SETD7) 108523124(KMT2C) 108523384(SETD1B) 108526582(SETD1A) 108526806(ASH1L) 108527467(SMYD2) 108528557(SMYD3) 108531292(KMT2E) 108536375(KMT2A) 108543918(KMT2D)
CJC: 100388751(SMYD1) 100389921(KMT2E) 100391138(KMT2A) 100392519(SMYD3) 100393607(ASH1L) 100398610(SETD1B) 100399648(PRDM7) 100401397(KMT2C) 100404005(SMYD2) 100407541(KMT2B) 100408425(KMT2D) 100414241(SETD7) 100415635(SETD1A)
SBQ: 101029847(KMT2A) 101033099(KMT2E) 101034359(KMT2B) 101037539(KMT2D) 101039502(SMYD3) 101042903(SETD1A) 101043413(SMYD1) 101043552(KMT2C) 101045177(SETD1B) 101046051(ASH1L) 101047679(SETD7) 101050442(SMYD2)
MMU: 12180(Smyd1) 192195(Ash1l) 208043(Setd1b) 213389(Prdm9) 214162(Kmt2a) 226830(Smyd2) 231051(Kmt2c) 233904(Setd1a) 381022(Kmt2d) 69188(Kmt2e) 69726(Smyd3) 73251(Setd7) 75410(Kmt2b)
MCAL: 110290320(Smyd3) 110291461(Ash1l) 110291535(Setd7) 110294014(Kmt2e) 110295015(Setd1b) 110295273(Kmt2c) 110296132(Smyd1) 110297666(Kmt2b) 110298244(Setd1a) 110298532(Smyd2) 110301786(Kmt2a) 110310214(Kmt2d) 110312704
MPAH: 110312745(Setd1b) 110313856(Kmt2e) 110316198(Kmt2c) 110316349(Smyd1) 110317687(Setd1a) 110320364(Setd7) 110320636(Ash1l) 110321293(Smyd3) 110322084(Smyd2) 110327485(Kmt2a) 110334561(Kmt2d) 110338243 110338314(Kmt2b)
RNO: 100359816(Setd1b) 100362634(Kmt2d) 102550344(Kmt2b) 289372(Smyd2) 297333(Smyd1) 310638(Ash1l) 311968(Kmt2e) 315606(Kmt2a) 365155(Prdm9) 498295(Smyd3) 502710(Kmt2c) 689954(Setd7)
MUN: 110545142(Setd7) 110545334(Setd1b) 110547438(Kmt2d) 110548961(Ash1l) 110549115(Kmt2a) 110550986(Kmt2b) 110552814(Kmt2e) 110553406(Smyd2) 110557574(Smyd3) 110559772 110559774 110561122(Prdm9) 110562254(Smyd1) 110564205 110564208
CGE: 100750575(Kmt2b) 100752747(Prdm9) 100753294(Setd1b) 100753962(Setd1a) 100754103(Ash1l) 100756731(Kmt2e) 100760424(Kmt2a) 100761694(Smyd2) 100764840(Smyd3) 100765465(Kmt2d) 100766221(Smyd1) 100767175(Setd7) 100767367(Kmt2c)
NGI: 103726333(Setd1a) 103727065(Smyd2) 103729965(Kmt2b) 103732191(Kmt2e) 103737043(Smyd1) 103739104(Setd1b) 103742349(Prdm9) 103742371(Setd7) 103745326(Kmt2c) 103746872(Smyd3) 103748298(Kmt2a) 103750570(Kmt2d) 103750808(Ash1l)
HGL: 101698170(Kmt2c) 101699273(Kmt2b) 101701112 101702850(Setd1b) 101709197(Setd1a) 101712321(Kmt2e) 101715832(Setd7) 101716671(Kmt2a) 101718411(Kmt2d) 101718535(Smyd1) 101720447(Smyd2) 101722574(Smyd3) 101723836(Ash1l)
CCAN: 109674462 109675706(Smyd3) 109682842(Setd1a) 109684282(Kmt2e) 109685268(Kmt2c) 109686401(Setd1b) 109688014(Ash1l) 109689598(Kmt2b) 109689973(Kmt2a) 109691464(Setd7) 109694824(Kmt2d) 109700578(Smyd1) 109700718(Smyd2) 109702113
OCU: 100344249(SMYD2) 100347516(SMYD3) 100347618(SETD1B) 100347837(SETD7) 100353483(KMT2B) 100353688(KMT2C) 100353733(KMT2A) 100353840(KMT2E) 100354139(SETD1A) 100354541(ASH1L) 100355437(SMYD1) 100357052(KMT2D) 100358830(PRDM7) 100358832 103347079
TUP: 102469443(ASH1L) 102470517(SETD7) 102473382(KMT2A) 102477772(KMT2B) 102478405(SETD1A) 102479012(KMT2C) 102480722(KMT2D) 102483069(KMT2E) 102483290(SMYD3) 102493552(SMYD1) 102496135(PRDM9) 102496151(SMYD2)
CFA: 100688666(KMT2B) 475758(SMYD1) 475895(KMT2E) 476079(SETD7) 479417(KMT2A) 480026(SMYD2) 480101(SMYD3) 480128(ASH1L) 486257(SETD1B) 486558(KMT2D) 489916(SETD1A) 611094(KMT2C)
VVP: 112916198(KMT2C) 112916807(SMYD1) 112918925(ASH1L) 112920160(KMT2A) 112921101(KMT2D) 112921783(SMYD2) 112923542(SMYD3) 112924552 112925373(KMT2E) 112928324(KMT2B) 112929256(SETD1A) 112934919(SETD7) 112935175(SETD1B)
AML: 100465228(KMT2C) 100466350(SMYD3) 100466490(SMYD2) 100468393(KMT2E) 100469094(KMT2B) 100469373(PRDM7) 100472168(SETD7) 100474237(ASH1L) 100478541(SETD1B) 100479447(KMT2D) 100482700(SETD1A) 100483766(SMYD1) 100484220(KMT2A) 109490334
UMR: 103658074(SETD7) 103660985(KMT2C) 103661268(SETD1B) 103662507(KMT2A) 103666923(SMYD3) 103668369(ASH1L) 103671476(SMYD1) 103672523(SMYD2) 103673975(PRDM7) 103674714(KMT2E) 103675622(KMT2D) 103682560(KMT2B)
UAH: 113241427(KMT2C) 113242840(SMYD1) 113244759(KMT2B) 113245266(ASH1L) 113251646(PRDM7) 113255688(SETD7) 113257661(KMT2D) 113258804(KMT2E) 113259992(KMT2A) 113262691(SMYD2) 113262946(SMYD3) 113266937(SETD1B) 113267709(SETD1A)
ORO: 101362332(KMT2E) 101362745(ASH1L) 101363669(KMT2A) 101364358(SMYD1) 101365628(KMT2C) 101368440(SETD7) 101369213(KMT2D) 101370290(KMT2B) 101371861(SMYD2) 101376995(SETD1A) 101383043(PRDM7) 101384991(SMYD3)
FCA: 101081435(SMYD2) 101084095(KMT2C) 101084945(KMT2E) 101085009(PRDM7) 101086114(ASH1L) 101089231(SMYD3) 101090288(KMT2A) 101091070(SETD1A) 101091191(SETD7) 101095247(SMYD1) 101095268(KMT2D) 101096419(SETD1B) 101098760(KMT2B)
PTG: 102949117(KMT2E) 102949463(SMYD3) 102953445(SETD7) 102956940(KMT2A) 102962859(KMT2D) 102964154(KMT2C) 102964982(KMT2B) 102968240(SMYD2) 102969005(SETD1A) 102969379(ASH1L) 102970032(SMYD1) 102970685(SETD1B) 102971819(PRDM7)
PPAD: 109245496(PRDM7) 109249058(KMT2D) 109249505(SETD7) 109251114(SMYD3) 109251503(KMT2B) 109252401(KMT2C) 109254457(SMYD2) 109256230(ASH1L) 109258968(SETD1A) 109264245(SMYD1) 109268101(KMT2E) 109277797(SETD1B) 109278556(KMT2A)
AJU: 106966460(KMT2A) 106966796(SMYD2) 106967594(SETD1B) 106968611(SMYD3) 106969329(KMT2D) 106974745(KMT2B) 106976180(SETD7) 106978140(SMYD1) 106978485(KMT2E) 106979084(SETD1A) 106981535(ASH1L) 106984461(KMT2C) 106985288(PRDM7)
BTA: 100139638 100190914(PRDM9) 100851938 506805(KMT2D) 508330(KMT2A) 514102(SETD1B) 515928(SETD7) 516002(PRDM7) 520584 537404(SMYD1) 539121(KMT2E) 540563(ASH1L) 615229(SMYD2) 616050(SMYD3) 782887(SETD1A) 785776(KMT2B) 789336(KMT2C)
BOM: 102267186(KMT2C) 102268887(KMT2D) 102269320(KMT2B) 102270977(SMYD1) 102271291 102273734(SMYD2) 102275046(ASH1L) 102279495(SETD1A) 102280025(KMT2A) 102280610(SETD1B) 102281278(KMT2E) 102281809(SETD7) 102282730 102287417(SMYD3)
BIU: 109553548(ASH1L) 109554959 109554963 109557366(KMT2E) 109558041(KMT2C) 109559148(KMT2D) 109561910 109566148(SMYD1) 109569413(KMT2A) 109570555(SMYD3) 109570591(SMYD2) 109570912(SETD1B) 109571070(SETD7) 109572325(KMT2B) 109578511(SETD1A)
BBUB: 102392548(SMYD3) 102393219(SETD1B) 102394548(SETD7) 102396938(KMT2C) 102398212(KMT2E) 102400596(KMT2B) 102401126(KMT2A) 102401677(SETD1A) 102401706(KMT2D) 102403578 102406655 102408066(SMYD1) 102413004 102415367(ASH1L) 102416088(SMYD2) 112582202 112582680 112582838
CHX: 102168698(KMT2D) 102169033(KMT2A) 102169548(KMT2E) 102170478(SETD1A) 102171177(SMYD3) 102172292(KMT2B) 102177044(PRDM9) 102179971(SETD1B) 102181925(KMT2C) 102183791(PRDM9) 102185413(ASH1L) 102185508 102187140(SMYD1) 102189783(SMYD2) 102191824(SETD7)
OAS: 101101875 101101916(KMT2A) 101102409(SMYD2) 101103509(SETD1B) 101103705 101104086(KMT2B) 101105467(SETD1A) 101108731(SMYD1) 101115617(KMT2C) 101115990(SETD7) 101116161(SMYD3) 101118592 101119775(ASH1L) 101120741(KMT2D) 101120895 101121766(KMT2E) 114116628
SSC: 100155920(ASH1L) 100156137(SETD1B) 100294702(SMYD1) 100294706(SMYD2) 100294707(SMYD3) 100511747(SETD1A) 100514805(KMT2C) 100520742(KMT2B) 100620538(PRDM7) 100623006(KMT2A) 100626704(SETD7) 100628131(KMT2E) 110260656(KMT2D)
CFR: 102506865(SETD7) 102507730(KMT2C) 102509980(SETD1A) 102510601(ASH1L) 102513005(SMYD1) 102514543(KMT2E) 102514741(SMYD3) 102515223(KMT2D) 102515785(SMYD2) 102517824(KMT2A) 102520520(KMT2B) 102521372(SETD1B)
CDK: 105087090(SETD7) 105088051 105088782(ASH1L) 105090168(KMT2A) 105093021(KMT2E) 105098689(KMT2C) 105099293(SMYD2) 105099491(SMYD3) 105102557(SETD1B) 105102789(SETD1A) 105103813(KMT2D) 105104177(SMYD1) 105106131(PRDM7)
BACU: 103002011(KMT2E) 103002269(SETD7) 103004413(KMT2D) 103004433(KMT2C) 103008957(SETD1A) 103010622(SETD1B) 103014183(KMT2A) 103015601(KMT2B) 103015822(ASH1L) 103018045(SMYD3) 103018379(SMYD1) 103018911(PRDM7) 103020103(SMYD2)
LVE: 103068531(KMT2A) 103070332(SMYD1) 103071598(SETD7) 103073652(KMT2B) 103074842(KMT2E) 103077679(SETD1B) 103078348(KMT2C) 103079757(SETD1A) 103081140(SMYD3) 103082116(KMT2D) 103083457(PRDM7) 103087473(ASH1L) 103090372(SMYD2)
OOR: 101269640(KMT2D) 101271862(SMYD2) 101276223(KMT2B) 101278571(KMT2A) 101278914(SETD1B) 101281657(SMYD3) 101282114(SETD7) 101283071(SETD1A) 101284649(SMYD1) 101285642(KMT2E) 101288516(KMT2C) 101288541(ASH1L) 101290159(PRDM7)
DLE: 111164613(KMT2E) 111165396(SMYD1) 111166868(KMT2A) 111167169(ASH1L) 111174034(KMT2D) 111176572(KMT2C) 111177545(SMYD3) 111179118(SETD7) 111179685(PRDM7) 111181136(KMT2B) 111182119(SETD1A) 111184680(SMYD2) 111186875(SETD1B)
PCAD: 102974760(PRDM7) 102977910(SETD1B) 102980726(KMT2E) 102980789(SMYD1) 102981848(KMT2D) 102986025(SETD7) 102987727(KMT2B) 102988929(KMT2C) 102989011(SMYD3) 102992344(SMYD2) 102992941(SETD1A) 102993773(ASH1L)
ECB: 100052774(SMYD2) 100052805(SMYD1) 100053168(PRDM7) 100057386(ASH1L) 100058928(KMT2E) 100058932(KMT2D) 100059267(SMYD3) 100059802(KMT2B) 100063257(SETD7) 100063523(SETD1A) 100064812(KMT2C) 100071238(KMT2A) 100146430(SETD1B)
EPZ: 103541678(SETD1B) 103546689(KMT2A) 103547761(SMYD2) 103548807 103549975(SMYD1) 103551020(SETD7) 103552202(KMT2D) 103552840 103553137(KMT2C) 103560579(KMT2E) 103562021 103566091(KMT2B) 103567807(PRDM7)
EAI: 106823334(KMT2C) 106825187(KMT2E) 106828486(ASH1L) 106829152(KMT2B) 106836860(KMT2D) 106838574(SMYD1) 106838612(SETD7) 106840333(KMT2A) 106842219(SETD1B) 106846818(SMYD2) 106846844(SMYD3)
MYB: 102244915(SMYD2) 102244965(KMT2D) 102246410(KMT2E) 102246482(SETD7) 102246704(KMT2C) 102247786(SMYD3) 102253255(SETD1A) 102255643 102256394(ASH1L) 102259087(KMT2B) 102262117
MYD: 102755932(SMYD1) 102756071(SETD1A) 102758785(KMT2E) 102759674(KMT2C) 102760166(SETD7) 102760582(SMYD2) 102762410(KMT2D) 102764796(ASH1L) 102765569 102769466(SMYD3) 102771251(KMT2B) 102774259
MNA: 107524895(KMT2C) 107528109(KMT2D) 107528337(SMYD3) 107528646(SMYD1) 107534917(SETD7) 107539362 107540799(SETD1A) 107542284(KMT2E) 107543372(KMT2B) 107543779(ASH1L) 107546243(SMYD2)
HAI: 109371387 109372008(KMT2B) 109374193(SETD1A) 109376837(SMYD1) 109378226 109378400 109378707 109378765 109379108(SMYD2) 109381405(PRDM7) 109385301(KMT2A) 109386061(SETD1B) 109389650(KMT2C) 109391450 109392049(KMT2E) 109393224(KMT2D) 109393386(ASH1L) 109394201(SETD7)
DRO: 112296748(PRDM7) 112297714(SMYD2) 112301980 112303106(SMYD1) 112303206(KMT2E) 112303918 112303963 112304818(SETD1A) 112308262(KMT2C) 112310608(SETD1B) 112312687(SETD7) 112313830 112314381(KMT2A) 112316652 112316914(ASH1L) 112318232(KMT2D) 112318753(SMYD3) 112320053(KMT2B)
PALE: 102878419(PRDM7) 102879153(SETD1B) 102880671(SMYD1) 102881431(KMT2B) 102883630(SMYD2) 102884674(SETD1A) 102887843(SMYD3) 102888124(ASH1L) 102888384(KMT2E) 102888593(KMT2D) 102889824(PRDM9) 102890289(SETD7) 102897550(KMT2C)
RAY: 107497624(KMT2B) 107498661(SMYD3) 107502258(KMT2A) 107503985(SETD1A) 107505913(SMYD1) 107508545 107511501(KMT2E) 107514237(KMT2D) 107515234(SETD1B) 107515339(SETD7) 107516247(PRDM9) 107520298(KMT2C) 107521457(ASH1L) 107521638(SMYD2)
MJV: 108383409(KMT2D) 108384991(KMT2A) 108385302(SETD1A) 108386199 108390371(SETD1B) 108392623(SMYD2) 108397889 108398321(PRDM7) 108398623(KMT2E) 108401519(KMT2B) 108404578(SMYD1) 108407349(ASH1L) 108408880(SETD7) 108409660
LAV: 100653681(KMT2A) 100653839(SETD7) 100659534(SMYD3) 100662609(SETD1A) 100664734 100666322(PRDM9) 100668468(ASH1L) 100668488(SETD1B) 100669611(KMT2B) 100670013(KMT2D) 100671071(KMT2E) 100672564(SMYD1) 100673765(KMT2C) 100674556(SMYD2) 100676686
MDO: 100013387(SETD1A) 100014976(PRDM7) 100017118(ASH1L) 100018480(KMT2E) 100019161(KMT2C) 100023305(SMYD2) 100027436(SETD7) 100029674(SMYD1) 100031440(KMT2A) 100617561(KMT2B) 100618514(SETD1B) 100619798(SMYD3) 103099827(KMT2D)
SHR: 100916165(SMYD1) 100920575(KMT2C) 100922144(KMT2E) 100923245 100924557(KMT2A) 100927672(KMT2B) 100928575(KMT2D) 100929261(SETD7) 100929291(SETD1A) 100931585(ASH1L) 100932883(SMYD3) 100934440(SMYD2)
PCW: 110194047(KMT2D) 110194897(SETD7) 110196348(SMYD1) 110196787(SETD1B) 110201341(KMT2B) 110201406(PRDM9) 110205493(SMYD3) 110206991(KMT2E) 110207193(KMT2A) 110211945(ASH1L) 110222694(SMYD2) 110223143(SETD1A) 110223876(KMT2C)
OAA: 100074286(KMT2C) 100074411(SETD1B) 100075773 100077208(KMT2E) 100078649(SMYD1) 100079176(SMYD2) 100081674(SETD7) 100082753(SMYD3) 100086068(KMT2A) 100090957(SETD1A) 103165316(KMT2B) 103168045(ASH1L) 114807912
GGA: 373960(SMYD1) 414897(KMT2A) 416851(SETD1B) 417712(KMT2E) 420437(KMT2C) 421361(SMYD2) 421489(SMYD3) 422443(SETD7) 425064(ASH1L) 425846(KMT2D)
MGP: 100538978(SMYD2) 100539732(ASH1L) 100540662(KMT2A) 100541967(SETD7) 100544670(SETD1B) 100545169(KMT2C) 100545555(KMT2E) 100548953(SMYD1) 104909329 104915798 109366408
CJO: 107308762(KMT2C) 107311083(SMYD2) 107311243(SMYD3) 107313101(SETD7) 107314020(SMYD1) 107321274(SETD1B) 107324133(KMT2A) 107324503(ASH1L) 107325180(KMT2E) 107325738(KMT2D)
NMEL: 110387546(KMT2A) 110387902(ASH1L) 110389135(KMT2D) 110392363(KMT2E) 110393789(KMT2C) 110395863(SMYD3) 110396134(SMYD2) 110397503(SETD7) 110398544(SMYD1) 110406578(SETD1B)
APLA: 101790791(SMYD2) 101796266(KMT2C) 101797321(KMT2A) 101800254(SETD7) 101800831(SMYD1) 101801343(SMYD3) 101803072(SETD1B) 101805084(KMT2E)
ACYG: 106031413(SETD1B) 106031578(SMYD2) 106033933(SMYD1) 106039772(KMT2A) 106040965(SETD7) 106043274(KMT2E) 106046952(KMT2C) 106047718(KMT2D) 106048498(ASH1L) 106049693(SMYD3)
TGU: 100219723(SMYD3) 100219994(SETD7) 100225647(SETD1B) 100226399(KMT2E) 100226907(KMT2D) 100227193(KMT2C) 100229714(ASH1L) 100230154(SMYD1) 100230503(SMYD2) 100231049(KMT2A)
LSR: 110468513(SETD7) 110470458(KMT2A) 110471483(ASH1L) 110471750(SETD1B) 110472726(KMT2E) 110473308(SMYD1) 110479948(SMYD2) 110480395(KMT2D) 110481707(SMYD3) 110484559(KMT2C)
SCAN: 103813061(KMT2C) 103813524(KMT2E) 103817699(SMYD3) 103818319(SETD1B) 103821549(SMYD2) 103822533(SETD7) 103822784(KMT2A) 103823501(SMYD1) 103823951(ASH1L) 103824625(KMT2D)
GFR: 102031396(KMT2C) 102032923(SMYD2) 102036439(KMT2A) 102037071(SMYD1) 102037758(SMYD3) 102040049(SETD1B) 102040515(SETD7) 102042927(ASH1L) 102045471(KMT2E)
FAB: 101806346(KMT2C) 101807006(SMYD2) 101807375(SETD7) 101812652(SETD1B) 101812878(KMT2E) 101813917(KMT2A) 101818086(KMT2D) 101819907(ASH1L) 101821319(SMYD3) 101822247(SMYD1)
PHI: 102099277(KMT2C) 102100454(KMT2D) 102101401(SMYD2) 102102416(SMYD1) 102103515(KMT2A) 102106186(SETD7) 102107307(SMYD3) 102108338(KMT2E) 102113028(ASH1L) 102114734(SETD1B)
PMAJ: 107198594(KMT2D) 107202071(SMYD2) 107202430(SMYD3) 107203381(SETD7) 107203527(SMYD1) 107204272(KMT2E) 107211664(SETD1B) 107214385(KMT2A) 107214568(ASH1L) 107216349(KMT2C)
CCAE: 111923252(KMT2E) 111925501(KMT2C) 111926193(SMYD2) 111927591 111928311(SMYD1) 111928908(SETD7) 111939213(KMT2A) 111939443(ASH1L)
CCW: 104683547(ASH1L) 104684478(SMYD3) 104685633(SMYD2) 104686428(KMT2C) 104686872(KMT2E) 104688830(SETD1B) 104690813(SMYD1) 104692048(KMT2A) 104697344(SETD7)
ETL: 114055005(SETD1B) 114056306(KMT2A) 114058383(SETD7) 114060528(KMT2E) 114060897(SMYD2) 114062389(KMT2C) 114065339(SMYD3) 114066019 114067206(SMYD1) 114069574(ASH1L)
FPG: 101911864(SETD1B) 101913546(ASH1L) 101917176(KMT2C) 101917301(SETD7) 101919056(SMYD1) 101919125(SMYD3) 101919912(KMT2E) 101922729(KMT2A) 101923412(SMYD2)
FCH: 102047191(KMT2C) 102047542(KMT2E) 102051296(SETD1B) 102053523(SETD7) 102056587(ASH1L) 102057033(SMYD1) 102057924(SMYD2) 102058880(SMYD3) 102059401(KMT2A)
CLV: 102083945(SETD1B) 102084453(KMT2A) 102086496(SMYD1) 102087865(SETD7) 102088613(SMYD2) 102088903(KMT2E) 102090928(ASH1L) 102092665(SMYD3) 102097963(KMT2C)
EGZ: 104122745(SETD1B) 104128583(KMT2E) 104130998(KMT2C) 104131533(SMYD3) 104132856(SMYD2) 104134673(SETD7) 104134854(ASH1L) 104135262 104135361(KMT2A)
NNI: 104010731(KMT2E) 104011458(SMYD3) 104014894(KMT2C) 104015980(SETD7) 104016208(KMT2A) 104018532(SMYD1) 104019711(SMYD2) 104020487(ASH1L) 104020788(SETD1B)
ACUN: 113477175(KMT2C) 113477910(SMYD3) 113478725(SMYD2) 113479169(SMYD1) 113479515(SETD7) 113485968(SETD1B) 113488577(KMT2A) 113488743(ASH1L) 113490163(KMT2E)
PADL: 103913294(ASH1L) 103914561(SETD1B) 103914598(SMYD3) 103915639(KMT2C) 103916551(KMT2A) 103920580(KMT2E) 103920974(SETD7) 103922130(SMYD2) 103923505(SMYD1)
AAM: 106484901(SMYD1) 106485191(KMT2A) 106485306(KMT2C) 106485538(SMYD3) 106485892(KMT2E) 106490428(SMYD2) 106491857(SETD7) 106494341(ASH1L) 106495668(SETD1B)
ASN: 102368053(SMYD1) 102372997(ASH1L) 102373099(KMT2D) 102374512(SETD7) 102375642(KMT2E) 102378568(SETD1B) 102379342(KMT2C) 102381556(SMYD3) 102382195(KMT2B) 102383161(SMYD2) 102385246(KMT2A)
AMJ: 102560388(KMT2E) 102567474(KMT2C) 102568755(SETD7) 102571713(ASH1L) 102572253(KMT2A) 102574091(SETD1B) 102575326(SMYD2) 102575695(SMYD1) 102576362(SMYD3) 102576444(SETD1A)
PSS: 102446823 102448089(SETD1B) 102448117(ASH1L) 102449156(SMYD1) 102454598(KMT2E) 102456582(SMYD3) 102459016(KMT2C) 102461265(SMYD2) 102461649(SETD7) 102463628(KMT2A)
CMY: 102931937(KMT2B) 102932627 102933355(KMT2E) 102933435(SMYD2) 102934693(SETD1B) 102936055(SMYD1) 102937036(SMYD3) 102941272(KMT2A) 102943205(SETD7) 102943662(ASH1L) 102948345(KMT2C)
CPIC: 101930966(SETD7) 101934288(KMT2D) 101935009(KMT2E) 101936901(SETD1A) 101939661(SETD1B) 101939705 101941687(KMT2A) 101942050(ASH1L) 101947848 101948178(SMYD2) 101950574(KMT2B) 101951595(SMYD1) 101951981(SMYD3) 101953918(KMT2C)
ACS: 100551939(setd7) 100553183(kmt2e) 100554175(kmt2d) 100556055(kmt2c) 100556600(kmt2b) 100557667(smyd2) 100560745(kmt2a) 100561699(smyd1) 100563888(ash1l) 103279564(setd1a) 103279992 107982259
PVT: 110071916(KMT2C) 110073660(SETD7) 110075080(KMT2D) 110076069(SMYD3) 110080953(KMT2E) 110081037(ASH1L) 110086348(SMYD1) 110086418(SETD1A) 110086747 110087176(SMYD2) 110089900(KMT2B)
PBI: 103049419 103051962(KMT2E) 103052345(SMYD3) 103054198(SMYD2) 103054534(SETD1A) 103055134(PRDM9) 103056555(SETD7) 103058624(SMYD1) 103058696(KMT2B) 103060233(ASH1L)
PMUR: 107286731 107287999(KMT2B) 107289289(SMYD2) 107289708 107293153(SETD7) 107297020(ASH1L) 107298635(KMT2E) 107302384(SMYD1) 107303312(KMT2C)
TSR: 106538172 106538415(SMYD2) 106543655(KMT2E) 106549276(SMYD3) 106550185(SMYD1) 106550780(KMT2B) 106552387(SETD7) 106556966(KMT2C)
PMUA: 114582254(SMYD1) 114582823(SETD1A) 114586229(ASH1L) 114587663 114594456(SMYD3) 114594675(SMYD2) 114603572(KMT2B) 114604135(SETD7) 114605818(KMT2E) 114607001(KMT2C)
GJA: 107105569(SMYD1) 107105838(KMT2D) 107106655(SETD1A) 107106688 107108065(SMYD3) 107108169(KMT2B) 107110772(SETD7) 107113725(KMT2E) 107119617(ASH1L) 107121665(SMYD2) 107123162(KMT2C)
XTR: 100135006(kmt2a) 100144721(kmt2b) 100145429(smyd1) 100486829(kmt2c) 100487270(setd1a) 100494109(kmt2d) 100494527(smyd3) 100495522(smyd2) 108645568(ash1l) 613102(setd7) 779539(kmt2e) 780106(setd1b)
NPR: 108783805(SMYD2) 108784343(KMT2C) 108787486(SMYD3) 108787523(SETD7) 108794233(ASH1L) 108795231(KMT2E) 108796886(SMYD1) 108799776(KMT2B) 108800988(SETD1A)
DRE: 100536523(kmt2d) 321245(smyd1a) 325395(kmt2e) 393876(prdm9) 436729(setd7) 541423(smyd2a) 556535(setd1a) 557048(kmt2a) 560793(kmt2ca) 560856(kmt2ba) 563799(ash1l) 566825(kmt2bb) 567970(setd1ba) 568162(kmt2cb) 568616(smyd2b) 569027(smyd1b) 569507(smyd3) 571274(setd1bb)
PRET: 103457564(smyd2) 103459296(kmt2e) 103460165(kmt2c) 103462777(smyd3) 103462839 103467355(kmt2d) 103468931(setd1a) 103470120 103470998(setd7) 103472504 103472762 103473729(setd1b) 103474100(smyd1) 103474566(kmt2a) 103478185(ash1l) 103478519(kmt2b) 103479582 103481653
NFU: 107372442(kmt2b) 107373342(setd1b) 107374212 107375014(smyd1) 107377597(smyd2) 107378515(setd1a) 107379592(ash1l) 107380358(kmt2a) 107381186 107381206(smyd3) 107383945(kmt2c) 107386366(kmt2e) 107387053(setd7) 107387683(znf286a) 107390885(kmt2d) 107394125 107394561 107394636
LCM: 102347272(KMT2C) 102349685(SMYD1) 102349988(KMT2E) 102350182(SETD7) 102354014(KMT2D) 102354519(SMYD2) 102357625 102361515(SMYD3) 102363172(SETD1B) 102367246(ASH1L)
CMK: 103176975(kmt2e) 103181297(setd7) 103181513(smyd1) 103181738(smyd3) 103186165(smyd2) 103189435(kmt2c) 103191129
DME: Dmel_CG13761(Smyd3) Dmel_CG3848(trr) Dmel_CG40351(Set1) Dmel_CG8651(trx) Dmel_CG8887(ash1)
DSI: Dsimw501_GD12268(Dsim_GD12268) Dsimw501_GD16408(Dsim_GD16408) Dsimw501_GD16997(Dsim_GD16997) Dsimw501_GD20433(Dsim_GD20433) Dsimw501_GD28717(Dsim_GD28717) Dsimw501_GD29063(Dsim_GD29063)
DAN: 6504613
DVI: 6634636
CEL: CELE_C26E6.9(set-2) CELE_R06F6.4(set-14) CELE_T12D8.1(set-16) CELE_T12F5.4(lin-59) CELE_T22A3.4(set-18) CELE_ZC8.3(set-30)
CBR: CBG03016(Cbr-set-14) CBG12017(Cbr-lin-59) CBG14580(Cbr-set-30) CBG18244(Cbr-set-16) CBG24752(Cbr-set-18)
ATH: AT1G43245 AT2G17900(SDG37) AT2G19640(ASHR2) AT4G15180(SDG2) AT5G06620(SDG38)
LJA: Lj0g3v0111689.1(Lj0g3v0111689.1) Lj0g3v0252639.1(Lj0g3v0252639.1) Lj0g3v0252639.2(Lj0g3v0252639.2) Lj1g3v0764540.1(Lj1g3v0764540.1) Lj1g3v0764540.2(Lj1g3v0764540.2) Lj2g3v2985910.1(Lj2g3v2985910.1) Lj2g3v2985910.2(Lj2g3v2985910.2) Lj2g3v2985910.3(Lj2g3v2985910.3) Lj3g3v2888370.1(Lj3g3v2888370.1) Lj3g3v2888370.2(Lj3g3v2888370.2) Lj4g3v0165060.1(Lj4g3v0165060.1) Lj4g3v0166140.1(Lj4g3v0166140.1)
DOSA: Os04t0423600-01(Os04g0423600) Os08t0180100-01(Os08g0180100) Os08t0205300-01(Os08g0205300) Os10t0410700-01(Os10g0410700)
ATS: 109736528(LOC109736528) 109741969(LOC109741969) 109747984(LOC109747984) 109776439(LOC109776439) 109778416(LOC109778416)
OLU: OSTLU_15174(SDG3512) OSTLU_32372(SDG3514) OSTLU_88595(SDG3527) OSTLU_92854(SDG3513)
SCE: YHR119W(SET1)
KMX: KLMA_30450(SET6) KLMA_60252(SET1)
NCS: NCAS_0B07030(NCAS0B07030) NCAS_0C01270(NCAS0C01270)
NDI: NDAI_0B04360(NDAI0B04360) NDAI_0K01280(NDAI0K01280)
TPF: TPHA_0I01480(TPHA0I01480)
TBL: TBLA_0C05500(TBLA0C05500)
TDL: TDEL_0A06370(TDEL0A06370) TDEL_0B05100(TDEL0B05100)
KAF: KAFR_0F00700(KAFR0F00700) KAFR_0H02340(KAFR0H02340)
SLB: AWJ20_424(SET6) AWJ20_608(SET1)
NCR: NCU01206(set-1) NCU01932(set-3) NCU02962
NTE: NEUTE1DRAFT125465(NEUTE1DRAFT_125465) NEUTE1DRAFT144212(NEUTE1DRAFT_144212) NEUTE1DRAFT150707(NEUTE1DRAFT_150707)
NHE: NECHADRAFT_123121(SDG2103) NECHADRAFT_49470(SDG2101) NECHADRAFT_74600(SDG2107)
ANG: ANI_1_1490164(An18g06840) ANI_1_1754144(An16g04950) ANI_1_2518094(An11g09860)
PBN: PADG_03985 PADG_06078 PADG_11427(PADG_02444)
SPO: SPBP8B7.07c(set6) SPCC306.04c(set1)
ABP: AGABI1DRAFT102088(AGABI1DRAFT_102088) AGABI1DRAFT120631(AGABI1DRAFT_120631) AGABI1DRAFT76762(AGABI1DRAFT_76762)
ABV: AGABI2DRAFT120820(AGABI2DRAFT_120820) AGABI2DRAFT211045(AGABI2DRAFT_211045) AGABI2DRAFT223832(AGABI2DRAFT_223832)
MGL: MGL_3610
MRT: MRET_0402
EHI: EHI_092690(175.t00011)
PYO: PY17X_1133200(PY04885)
PCB: PCHAS_113130(PC000913.02.0)
CPV: cgd7_5090
SMIN: v1.2.013565.t1(symbB.v1.2.013565.t1) v1.2.019699.t1(symbB.v1.2.019699.t1) v1.2.029529.t3(symbB.v1.2.029529.t3) v1.2.035053.t1(symbB.v1.2.035053.t1)
 » show all
Taxonomy
Reference
1  [PMID:12453419]
  Authors
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E
  Title
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  Journal
Mol Cell 10:1119-28 (2002)
DOI:10.1016/s1097-2765(02)00740-2
  Sequence
[hsa:4297]
Reference
2  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
3  [PMID:15235609]
  Authors
Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y
  Title
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
  Journal
Nat Cell Biol 6:731-40 (2004)
DOI:10.1038/ncb1151
  Sequence
[hsa:64754]
Reference
4  [PMID:27129774]
  Authors
Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M
  Title
PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.
  Journal
J Biol Chem 291:13509-19 (2016)
DOI:10.1074/jbc.M116.721472
  Sequence
[hsa:11105]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.354
IUBMB Enzyme Nomenclature: 2.1.1.354
ExPASy - ENZYME nomenclature database: 2.1.1.354
BRENDA, the Enzyme Database: 2.1.1.354

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