KEGG   ENZYME: 1.1.1.213Help
Entry
EC 1.1.1.213                Enzyme                                 

Name
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific);
3alpha-hydroxysteroid dehydrogenase;
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific);
3alpha-hydroxysteroid 3-dehydrogenase (A-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3alpha-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 1.1.1.357, 3alpha-hydroxysteroid 3-dehydrogenase.
History
EC 1.1.1.213 created 1986, modified 2012
Pathway
ec00140  Steroid hormone biosynthesis
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K00089  3alpha-hydroxysteroid 3-dehydrogenase
K04119  aldo-keto reductase family 1 member C3
Genes
HSA: 1646(AKR1C2) 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100986388(AKR1C3) 103783188
GGO: 101144878
PON: 100174617(AKR1C3)
NLE: 100604844(AKR1C3)
MCC: 711440(AKR1C3)
MCF: 102142023(HSD17B5)
RBB: 108532990
SBQ: 101041594
CFA: 497070(AKR1C3)
FCA: 100510801(AKR1C3)
PTG: 102963188
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884 785762
BOM: 102269337
BIU: 109568087
SSC: 733634(AKR1C1)
LVE: 103069218
ECB: 100070616
MYB: 102255491
MYD: 102751586
TMU: 101342771
OAA: 100085065
PSS: 102446010
PVT: 110088827
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 105946859 779627(akr1c3)
 » show all
Taxonomy
Reference
1  [PMID:4392180]
  Authors
Bjorkhem I, Danielsson H.
  Title
Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver.
  Journal
Eur J Biochem 12:80-4 (1970)
DOI:10.1111/j.1432-1033.1970.tb00823.x
Reference
2  [PMID:13278351]
  Authors
TOMKINS GM.
  Title
A mammalian 3alpha-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 218:437-47 (1956)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.213
IUBMB Enzyme Nomenclature: 1.1.1.213
ExPASy - ENZYME nomenclature database: 1.1.1.213
BRENDA, the Enzyme Database: 1.1.1.213
CAS: 9028-56-2

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