KEGG   ENZYME: 1.3.8.1Help
Entry
EC 1.3.8.1                  Enzyme                                 

Name
short-chain acyl-CoA dehydrogenase;
butyryl-CoA dehydrogenase;
butanoyl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADS (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R01178]
Reaction(KEGG)
Substrate
short-chain acyl-CoA [CPD:C20675];
electron-transfer flavoprotein [CPD:C04253]
Product
short-chain trans-2,3-dehydroacyl-CoA [CPD:C20676];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.1 created 1961 as EC 1.3.2.1, transferred 1964 to EC 1.3.99.2, transferred 2011 to EC 1.3.8.1, modified 2012
Pathway
ec00071  Fatty acid degradation
ec00280  Valine, leucine and isoleucine degradation
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00248  butyryl-CoA dehydrogenase
Genes
HSA: 35(ACADS)
PTR: 742921(ACADS)
PPS: 100994372(ACADS)
GGO: 101139640(ACADS)
PON: 100172331(ACADS)
NLE: 100586242(ACADS)
MCC: 698196(ACADS)
MCF: 102116240(ACADS)
CSAB: 103239266(ACADS)
RRO: 104666263(ACADS)
RBB: 108529647(ACADS)
CJC: 100387870(ACADS)
SBQ: 101049174(ACADS)
MMU: 11409(Acads)
RNO: 64304(Acads)
CGE: 100774097(Acads)
NGI: 103740119(Acads)
HGL: 101722158(Acads)
CCAN: 109696148(Acads)
OCU: 100352290(ACADS)
TUP: 102494372(ACADS)
CFA: 477517(ACADS)
AML: 100483719(ACADS)
UMR: 103678351(ACADS)
ORO: 101363887(ACADS)
FCA: 101082442(ACADS)
PTG: 102956610(ACADS)
AJU: 106971681(ACADS)
BTA: 511222(ACADS)
BOM: 102269247(ACADS)
BIU: 109571341(ACADS)
PHD: 102337341(ACADS)
CHX: 102180069(ACADS)
OAS: 101119850(ACADS)
SSC: 396932(ACADS)
CFR: 102503720(ACADS)
CDK: 105101985(ACADS)
BACU: 103010876(ACADS)
LVE: 103083994(ACADS)
OOR: 101278842(ACADS)
ECB: 100147113(ACADS)
EPZ: 103540479(ACADS)
EAI: 106844801(ACADS)
MYB: 102250514(ACADS)
MYD: 102760180(ACADS)
HAI: 109386149(ACADS)
RSS: 109445457(ACADS)
PALE: 102891595(ACADS)
LAV: 100669421(ACADS)
TMU: 101356048
MDO: 100025804(ACADS)
SHR: 100917746(ACADS)
OAA: 100090404(ACADS)
GGA: 416969(ACADS)
MGP: 100541626(ACADS)
CJO: 107321246(ACADS)
APLA: 101801937(ACADS)
ACYG: 106031343(ACADS)
TGU: 100232428(ACADS)
GFR: 102031606(ACADS)
FAB: 101818866(ACADS)
PHI: 102112248(ACADS)
PMAJ: 107211533(ACADS)
CCAE: 111936603(ACADS)
CCW: 104688759(ACADS)
FPG: 101913588(ACADS)
FCH: 102052397(ACADS)
CLV: 102088733(ACADS)
EGZ: 104129891(ACADS)
AAM: 106486315(ACADS)
ASN: 102368188(ACADS)
AMJ: 102559145(ACADS)
PSS: 102460079(ACADS)
CMY: 102946552(ACADS)
CPIC: 101934662(ACADS)
ACS: 100557906(acads)
PVT: 110081950(ACADS)
PBI: 103059584(ACADS)
GJA: 107126092(ACADS)
XLA: 380563(acads.L)
XTR: 394882(acads)
NPR: 108787757(ACADS)
DRE: 445288(acads)
SRX: 107741687
SANH: 107689539
SGH: 107567748
IPU: 100305084(acads)
AMEX: 111190888(acads)
TRU: 101071269(acads)
LCO: 104937354(acads)
NCC: 104954167(acads)
MZE: 101477731(acads)
OLA: 101166811(acads)
XMA: 102223580(acads)
PRET: 103473179(acads)
NFU: 107394661(acads)
KMR: 108244766(acads)
CSEM: 103389931(acads)
LCF: 108895632(acads)
SDU: 111224280(acads)
HCQ: 109525105(acads)
BPEC: 110166693(acads)
MALB: 109974764(acads)
OTW: 112220230
ELS: 105015217
SFM: 108930016(acads)
LCM: 102355418(ACADS)
CMK: 103182182(acads)
CIN: 100175610
SPU: 579817
APLC: 110980734
SKO: 100372351
DME: Dmel_CG4703(Arc42) Dmel_CG4860(CG4860)
DPO: Dpse_GA18369(Dpse_Arc42) Dpse_GA18485
DER: Dere_GG17152 Dere_GG23560(Dere_Arc42)
DSI: Dsimw501_GD19319(Dsim_GD19319) Dsimw501_GD20592(Dsim_GD20592)
DWI: Dwil_GK11564 Dwil_GK22361(Dwil_Arc42)
MDE: 101894967
AME: 411697
BIM: 100741796
BTER: 100644786
SOC: 105194539
AEC: 105153957
ACEP: 105618056
PBAR: 105433071
HST: 105189744
DQU: 106741964
CFO: 105248503
LHU: 105677833
PGC: 109856861
PCF: 106793225
NVI: 100123507(Acads)
MDL: 103571272
DPA: 109544050
NVL: 108564815
BMOR: 101743734
PMAC: 106711086
PRAP: 110991435
HAW: 110370948
PXY: 105386881
API: 100168685
DNX: 107167049
CLEC: 106665378
ZNE: 110829314
FCD: 110852939
CRG: 105344312
MYI: 110462869
OBI: 106874336
LAK: 106156920
ADF: 107340803
PTI: PHATR_25932(ACD1)
FCY: FRACYDRAFT_209569(ACD1)
TPS: THAPS_35710(ACD1)
SPAR: SPRG_09395
PAE: PA5020
PAEV: N297_5193
PAEI: N296_5193
PAEP: PA1S_27220
PAEM: U769_27475
PAEL: T223_27680
PAEG: AI22_06775
PAEC: M802_5191
PAEO: M801_5058
PMY: Pmen_0561
PMK: MDS_0639
PPSE: BN5_0454(bcd)
PPU: PP_4948
PPF: Pput_4821
PPT: PPS_4792
PPI: YSA_03995
PPX: T1E_1162(acad8)
PPUH: B479_24200
PPUT: L483_29890
PPUN: PP4_50130
PPUD: DW66_5180
PMON: X969_23660
PMOT: X970_23295
PSB: Psyr_0505
PSYR: N018_23575
PFL: PFL_0494
PPRO: PPC_0508
PFS: PFLU_0450
PFB: VO64_3531
PMAN: OU5_3012
PEN: PSEEN5004
PSA: PST_3878
PSTT: CH92_19235
PKC: PKB_5329
PSEM: TO66_02395
PSOS: POS17_0486
PALI: A3K91_1710
SFR: Sfri_2066
SLO: Shew_2868
PAT: Patl_2141
MAQ: Maqu_2845
MHC: MARHY2737
MAD: HP15_2576
MBS: MRBBS_2807(mmgC)
AMAL: I607_10830
AMAE: I876_11195
AMAO: I634_11055
AMAD: I636_11085
AMAI: I635_11485
AMAG: I533_10810
AMAC: MASE_10520
AAUS: EP12_11555
GNI: GNIT_1921(bcd)
SAGA: M5M_08525
LPF: lpl0900
LPP: lpp0931
ABO: ABO_0833 ABO_1918(acdS)
TOL: TOL_0957
RSO: RSc1762
RSN: RSPO_c01798(aidB)
RSE: F504_1627(dmdC)
RPI: Rpic_1444
REH: H16_A1530(h16_A1530) H16_B0752(h16_B0752) H16_B0850(h16_B0850)
RME: Rmet_1852
CGD: CR3_1478(bcd)
BCN: Bcen_0860
BCJ: BCAL1333
BCEO: I35_1228
BAM: Bamb_1233
BCED: DM42_376
BCON: NL30_08980
BUB: BW23_4660
BFN: OI25_4049
POL: Bpro_2570
AAV: Aave_2877
AJS: Ajs_1687
AAA: Acav_2365
VEI: Veis_1790
DAC: Daci_3315
RTA: Rta_20030
MPT: Mpe_A1777
JAG: GJA_2432
TIN: Tint_1593
GME: Gmet_1715
GUR: Gura_3040
GBM: Gbem_2832
GEO: Geob_2186
GEM: GM21_1381
GEB: GM18_1288
DAL: Dalk_1296
MXA: MXAN_0797
CCX: COCOR_00683(aidB)
HOH: Hoch_4640
SFU: Sfum_1371
BBA: Bd1973
BMX: BMS_2770(bcd)
RPE: RPE_3222
MEX: Mext_4104
RDE: RD1_3681(acdA)
HBA: Hbal_2852
SJP: SJA_C1-01450(bcd)
ACR: Acry_1573
RRU: Rru_A1308
RCE: RC1_2142
TMO: TMO_0629
BCL: ABC1506
OIH: OB1695
LBR: LVIS_1909
LBH: Lbuc_0346
CRN: CAR_c21860(acdA)
CAC: CA_C2711(bcd)
CAE: SMB_G2746(bcd)
CAY: CEA_G2719(bcd)
CPF: CPF_0092 CPF_2584(bcd)
CPR: CPR_2286(bcd)
CBO: CBO3199(bcd)
CBA: CLB_3235(bcd)
CBH: CLC_3109(bcd)
CBY: CLM_3611(bcd)
CBL: CLK_2597(bcd)
CBB: CLD_1332(bcd)
CBI: CLJ_B3471(bcd)
CBN: CbC4_1602
CBF: CLI_3338(bcd)
CBM: CBF_3330(bcd)
CKL: CKL_0455(bcd)
CKR: CKR_0400
CSR: Cspa_c04340(bcd1) Cspa_c20900(bcd3)
CPAS: Clopa_1420
CPAT: CLPA_c11000(bcd2) CLPA_c28620(bcd3)
CPAE: CPAST_c11000(bcd2) CPAST_c28620(bcd3)
CSB: CLSA_c03570(bcd1) CLSA_c40890(bcd4)
CLT: CM240_1171(bcd)
CBV: U729_1464
CLD: CLSPO_c33020(bcd3)
CTYK: CTK_C26360(bcd1) CTK_C28050(bcd4)
AMT: Amet_3091
BPB: bpr_I2485(bcd)
CSO: CLS_36820
CDF: CD630_10540(bcd2)
PDC: CDIF630_01194(bcd)
CDC: CD196_0931(bcd2)
CDL: CDR20291_0910(bcd2)
PDF: CD630DERM_10540(bcd2)
DSY: DSY1568
DHD: Dhaf_2695
PTH: PTH_0015(CaiA) PTH_0513(CaiA) PTH_1769(CaiA)
OVA: OBV_03770(acdA) OBV_16240(acdA) OBV_28830(acdA) OBV_33360(acdA) OBV_40740(acdA)
BPRM: CL3_07570
TTE: TTE0545(CaiA)
CHY: CHY_1350(bcd2) CHY_1602(bcd3)
TTM: Tthe_1660
APR: Apre_1356
MMC: Mmcs_0182
MKM: Mkms_0191
MJL: Mjls_0171
ASD: AS9A_2599
NFA: NFA_24470(fadE24)
GBR: Gbro_3567
TPR: Tpau_0702
NCA: Noca_3506
NDA: Ndas_1582
TCU: Tcur_1227
FAL: FRAAL6072
ACE: Acel_0405
GOB: Gobs_4675
PDX: Psed_4004
MIL: ML5_5681
RXY: Rxyl_1707
DRA: DR_A0250
DGE: Dgeo_2405
TTH: TT_C0238
TTJ: TTHB022
MRB: Mrub_2720
BHY: BHWA1_01911(acaD)
BRM: Bmur_1546
BPO: BP951000_1040(acaD)
BPW: WESB_2382
BIP: Bint_2792(acaD)
ACA: ACP_2397
SUS: Acid_5310
BACC: BRDCF_p446(bcd)
PGI: PG_1076(acdA)
PGN: PGN_1172
SLI: Slin_1076
TLE: Tlet_1831
TME: Tmel_0656
TAF: THA_730
FNO: Fnod_0585
CEX: CSE_15010
PIS: Pisl_1436
PCL: Pcal_0838
PAS: Pars_0456
 » show all
Taxonomy
Reference
1  [PMID:13130522]
  Authors
MAHLER HR.
  Title
Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase.
  Journal
J Biol Chem 206:13-26 (1954)
Reference
2  [PMID:13130521]
  Authors
GREEN DE, MII S, MAHLER HR, BOCK RM
  Title
Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase.
  Journal
J Biol Chem 206:1-12 (1954)
Reference
3
  Authors
Beinert, H.
  Title
Acyl coenzyme A dehydrogenase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466.
Reference
4  [PMID:6712627]
  Authors
Shaw L, Engel PC
  Title
The purification and properties of ox liver short-chain acyl-CoA dehydrogenase.
  Journal
Biochem J 218:511-20 (1984)
Reference
5  [PMID:7601336]
  Authors
Thorpe C, Kim JJ
  Title
Structure and mechanism of action of the acyl-CoA dehydrogenases.
  Journal
FASEB J 9:718-25 (1995)
Reference
6  [PMID:3968063]
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K.
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J Biol Chem 260:1311-25 (1985)
  Sequence
[rno:64304]
Reference
7  [PMID:16024185]
  Authors
McMahon B, Gallagher ME, Mayhew SG
  Title
The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA  dehydrogenase that oxidises only short-chain aliphatic substrates.
  Journal
FEMS Microbiol Lett 250:121-7 (2005)
DOI:10.1016/j.femsle.2005.06.049
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.1
IUBMB Enzyme Nomenclature: 1.3.8.1
ExPASy - ENZYME nomenclature database: 1.3.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.8.1
BRENDA, the Enzyme Database: 1.3.8.1
CAS: 9027-88-7

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