KEGG   Homo sapiens (human): 102
Entry
102               CDS       T01001                                 
Symbol
ADAM10, AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz
Name
(RefSeq) ADAM metallopeptidase domain 10
  KO
K06704  disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa05010  Alzheimer disease
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
Network
nt06535  Efferocytosis
  Element
N01749  Find-me signal (CX3CL1)
Disease
H00056  Alzheimer disease
H02665  Reticulate acropigmentation of Kitamura
Drug target
Aderbasib: D09320
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102 (ADAM10)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    102 (ADAM10)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102 (ADAM10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    102 (ADAM10)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    102 (ADAM10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.81  ADAM10 endopeptidase
     102 (ADAM10)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   102 (ADAM10)
CD molecules [BR:hsa04090]
 Proteins
  102 (ADAM10)
SSDB
Motif
Pfam: Reprolysin_2 Reprolysin_5 Reprolysin_3 ADAM10_Cys-rich Reprolysin_4 Disintegrin Pep_M12B_propep Reprolysin Peptidase_M66
Other DBs
NCBI-GeneID: 102
NCBI-ProteinID: NP_001101
OMIM: 602192
HGNC: 188
Ensembl: ENSG00000137845
UniProt: O14672
Structure
Position
15:complement(58588809..58749707)
AA seq 748 aa
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
NT seq 2247 nt   +upstreamnt  +downstreamnt
atggtgttgctgagagtgttaattctgctcctctcctgggcggcggggatgggaggtcag
tatgggaatcctttaaataaatatatcagacattatgaaggattatcttacaatgtggat
tcattacaccaaaaacaccagcgtgccaaaagagcagtctcacatgaagaccaattttta
cgtctagatttccatgcccatggaagacatttcaacctacgaatgaagagggacacttcc
cttttcagtgatgaatttaaagtagaaacatcaaataaagtacttgattatgatacctct
catatttacactggacatatttatggtgaagaaggaagttttagccatgggtctgttatt
gatggaagatttgaaggattcatccagactcgtggtggcacattttatgttgagccagca
gagagatatattaaagaccgaactctgccatttcactctgtcatttatcatgaagatgat
attaactatccccataaatacggtcctcaggggggctgtgcagatcattcagtatttgaa
agaatgaggaaataccagatgactggtgtagaggaagtaacacagatacctcaagaagaa
catgctgctaatggtccagaacttctgaggaaaaaacgtacaacttcagctgaaaaaaat
acttgtcagctttatattcagactgatcatttgttctttaaatattacggaacacgagaa
gctgtgattgcccagatatccagtcatgttaaagcgattgatacaatttaccagaccaca
gacttctccggaatccgtaacatcagtttcatggtgaaacgcataagaatcaatacaact
gctgatgagaaggaccctacaaatcctttccgtttcccaaatattggtgtggagaagttt
ctggaattgaattctgagcagaatcatgatgactactgtttggcctatgtcttcacagac
cgagattttgatgatggcgtacttggtctggcttgggttggagcaccttcaggaagctct
ggaggaatatgtgaaaaaagtaaactctattcagatggtaagaagaagtccttaaacact
ggaattattactgttcagaactatgggtctcatgtacctcccaaagtctctcacattact
tttgctcacgaagttggacataactttggatccccacatgattctggaacagagtgcaca
ccaggagaatctaagaatttgggtcaaaaagaaaatggcaattacatcatgtatgcaaga
gcaacatctggggacaaacttaacaacaataaattctcactctgtagtattagaaatata
agccaagttcttgagaagaagagaaacaactgttttgttgaatctggccaacctatttgt
ggaaatggaatggtagaacaaggtgaagaatgtgattgtggctatagtgaccagtgtaaa
gatgaatgctgcttcgatgcaaatcaaccagagggaagaaaatgcaaactgaaacctggg
aaacagtgcagtccaagtcaaggtccttgttgtacagcacagtgtgcattcaagtcaaag
tctgagaagtgtcgggatgattcagactgtgcaagggaaggaatatgtaatggcttcaca
gctctctgcccagcatctgaccctaaaccaaacttcacagactgtaataggcatacacaa
gtgtgcattaatgggcaatgtgcaggttctatctgtgagaaatatggcttagaggagtgt
acgtgtgccagttctgatggcaaagatgataaagaattatgccatgtatgctgtatgaag
aaaatggacccatcaacttgtgccagtacagggtctgtgcagtggagtaggcacttcagt
ggtcgaaccatcaccctgcaacctggatccccttgcaacgattttagaggttactgtgat
gttttcatgcggtgcagattagtagatgctgatggtcctctagctaggcttaaaaaagca
atttttagtccagagctctatgaaaacattgctgaatggattgtggctcattggtgggca
gtattacttatgggaattgctctgatcatgctaatggctggatttattaagatatgcagt
gttcatactccaagtagtaatccaaagttgcctcctcctaaaccacttccaggcacttta
aagaggaggagacctccacagcccattcagcaaccccagcgtcagcggccccgagagagt
tatcaaatgggacacatgagacgctaa

  All links  
Disease (3)   
   OMIM (3)   
Gene (19)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
Protein domain (9)   
   Pfam (9)   
All databases (68)   

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