KEGG T01001: 1656

Homo sapiens (human): 1656

Entry

1656 CDS T01001

Gene name

DDX6, HLR2, P54, RCK

Definition

(RefSeq) DEAD-box helicase 6

K12614

ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.4.13]

Organism

hsa Homo sapiens (human)

Pathway

hsa03018

RNA degradation

Module

hsa_M00395

Decapping complex

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    1656 (DDX6)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1656 (DDX6)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1656 (DDX6)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.13  RNA helicase
     1656 (DDX6)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     1656 (DDX6)
  mRNA degradation factors
   5'-3' decay
    Decapping complex
     1656 (DDX6)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic Type
  Gene silencing
   piRNA pathway
    1656 (DDX6)

SSDB

Motif

Pfam:

DEAD Helicase_C CMS1 ResIII ERCC3_RAD25_C

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P26196(Tbio)

UniProt:

P26196 B2R858

Structure

PDB:

4CRW 1VEC 5ANR 4CT4 2WAX 2WAY 4CT5 6F9S

Position

11q23.3

AA seq 483 aa
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ
SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS
PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV
SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV
QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL
MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS
CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH
RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED
EKP

NT seq 1452 nt +upstreamnt +downstreamnt
atgagcacggccagaacagagaaccctgttataatgggtctgtccagtcaaaatggtcag
ctgagaggccctgtgaaacccactggtggccctggaggagggggcacacagacacagcaa
cagatgaaccagctgaaaaacaccaacacaatcaataatggcactcagcagcaagcacag
agtatgaccaccactattaaacctggtgatgactggaaaaagactttaaaactccctcca
aaggatctaagaatcaaaacttcggatgtgacctccacaaaaggaaatgagtttgaagat
tactgtttgaaacgggagttactgatgggaatttttgaaatgggctgggaaaagccatct
cctattcaggaggagagcattcccattgctttatctggtagggatatcttagctagagca
aaaaatggaacaggcaagagcggtgcctacctcattcccttacttgaacggctagacctg
aagaaggacaatatacaagcaatggtgattgttcccactagagaacttgctctacaggtc
agtcaaatttgcatccaggtcagcaaacacatgggaggggccaaagtgatggcaaccaca
ggaggaaccaatttacgagatgacataatgaggcttgatgatacagtgcacgtggtgatt
gctacccctgggagaatcctggatcttattaagaaaggagtagcaaaggttgatcatgtc
cagatgatagtattggatgaggcagataagttgctgtcacaggattttgtgcagataatg
gaggatattattctcacgctacctaaaaacaggcagattttactatattccgctactttc
cctcttagtgtacagaagttcatgaattcccatttgcagaaaccctatgagattaacctg
atggaggaactaactctgaagggagtaacccagtactacgcatatgtaactgagcgccaa
aaagtacactgcctcaacacacttttctccaggcttcagataaaccagtcgatcattttc
tgtaactcctctcagcgagttgaattgctagccaagaagatttctcaactgggttattct
tgcttctatattcatgctaaaatgaggcaggaacatcgaaatcgtgtatttcatgatttc
cgaaatggcttatgccgcaatcttgtttgcactgatctgtttacccgaggtattgatata
caagctgtgaatgtggtaataaactttgatttcccaaagctggcagagacctatctccat
cgtattggaagatcaggtcgctttggtcatcttggcttagccatcaacttgatcacatat
gatgatcgcttcaacctgaaaagtattgaggagcagctgggaacagaaattaaacctatt
ccgagcaacattgataagagcctgtatgtggcagaataccacagcgagcctgtagaagat
gagaaaccttaa

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